ID M3WR11_FELCA Unreviewed; 302 AA.
AC M3WR11;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Folate receptor alpha {ECO:0000313|Ensembl:ENSFCAP00000016793.2};
GN Name=FOLR1 {ECO:0000313|Ensembl:ENSFCAP00000016793.2,
GN ECO:0000313|VGNC:VGNC:102889};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000016793.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000016793.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016793.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000016793.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016793.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000016793.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016793.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the folate receptor family.
CC {ECO:0000256|ARBA:ARBA00007932}.
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DR EMBL; AANG04002890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WR11; -.
DR STRING; 9685.ENSFCAP00000016793; -.
DR PaxDb; 9685-ENSFCAP00000016793; -.
DR Ensembl; ENSFCAT00000027144.4; ENSFCAP00000016793.2; ENSFCAG00000036714.3.
DR VGNC; VGNC:102889; FOLR1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000183144; -.
DR HOGENOM; CLU_070826_1_1_1; -.
DR InParanoid; M3WR11; -.
DR OMA; HKQCSPW; -.
DR Proteomes; UP000011712; Chromosome D1.
DR Bgee; ENSFCAG00000036714; Expressed in adult mammalian kidney and 9 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005542; F:folic acid binding; IEA:Ensembl.
DR GO; GO:0061714; F:folic acid receptor activity; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0061713; P:anterior neural tube closure; IEA:Ensembl.
DR GO; GO:0031103; P:axon regeneration; IEA:Ensembl.
DR GO; GO:0003253; P:cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0046655; P:folic acid metabolic process; IEA:Ensembl.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IBA:GO_Central.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0003147; P:neural crest cell migration involved in heart formation; IEA:Ensembl.
DR GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035036; P:sperm-egg recognition; IBA:GO_Central.
DR InterPro; IPR004269; Folate_rcpt.
DR InterPro; IPR018143; Folate_rcpt-like.
DR PANTHER; PTHR10517; FOLATE RECEPTOR; 1.
DR PANTHER; PTHR10517:SF15; FOLATE RECEPTOR ALPHA; 1.
DR Pfam; PF03024; Folate_rec; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 271..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..254
FT /note="Folate receptor-like"
FT /evidence="ECO:0000259|Pfam:PF03024"
SQ SEQUENCE 302 AA; 34193 MW; 23B90FC5172F0CB1 CRC64;
MKIGVGVGHD GAQVSWRLHP PGAIPTHLEA PPLLSLVPLT TGLPSDTDMA QLVTTELLLL
LAGVAAVWAA RPRTELLNVC MDAKHHKEKP SPEDELHEQC RPWKKNSCCF ANTSREAHKD
ISYLYRFNWD HCGQMAPACK QHFIQDTCLY ECSPNLGPWI QQVNQSWRKE RILNVPLCKE
DCQQWWEDCR TSYTCKSNWH KGWDWSSGHN RCPVGAACHH FHFYFPTPAA LCEGIWSHSY
KLSNYSRGSG RCIQMWFDPA QGNPNEEVAR FYALAMSAGA MSHGIGLLLL SLIPMLQLWL
LS
//
