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Database: UniProt
Entry: M3WRT5_FELCA
LinkDB: M3WRT5_FELCA
Original site: M3WRT5_FELCA 
ID   M3WRT5_FELCA            Unreviewed;       957 AA.
AC   M3WRT5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   23-MAY-2018, entry version 44.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 6 {ECO:0000313|Ensembl:ENSFCAP00000017070};
GN   Name=KCNH6 {ECO:0000313|Ensembl:ENSFCAP00000017070};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017070, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000017070, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017070,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000017070}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017070};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000017070}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017070};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
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DR   EMBL; AANG03014685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_019673645.1; XM_019818086.1.
DR   STRING; 9685.ENSFCAP00000017070; -.
DR   Ensembl; ENSFCAT00000031591; ENSFCAP00000017070; ENSFCAG00000024807.
DR   GeneID; 101083379; -.
DR   CTD; 81033; -.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140833; -.
DR   InParanoid; M3WRT5; -.
DR   OMA; ADSFWSK; -.
DR   OrthoDB; EOG091G024C; -.
DR   Proteomes; UP000011712; Chromosome E1.
DR   Bgee; ENSFCAG00000024807; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 1.20.120.350; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR   InterPro; IPR030172; KCNH6.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10217:SF468; PTHR10217:SF468; 2.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01470; ERGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|SAAS:SAAS00920127};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    261    282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    294    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    337    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    398    422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    491    515       Helical. {ECO:0000256|SAM:Phobius}.
FT   COILED      792    812       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   957 AA;  106369 MW;  A954E7E025B1A694 CRC64;
     MPVRRGHVAP QNTYLDTIIR KFEGQSRKFL IANAQMENCA IIYCNDGFCE LFGYSRVEVM
     QRPCTCDFLT GPNTPRSAMS RLAQALLGTE ECKVDILYYR KDASSFRCLV DVVPVKNEDG
     AVIMFILNFE DLAQLLAKSE RRSLSQCLLS QSFLGSEGSH GRPGAQGPGT GRVKYRTISQ
     IPQFTLNFVE FNLEKHRSGS TTEIEIIAPH KVVERTQNVT EKVTQVLSLG ADVLPEYKLQ
     APRIHRGTLL HYSPFKAVWD WLILLLVIYT AIFTPYSAAF LLSDQDESQR MDCGYTCSPL
     TVVDLIVDIM FVVDIVINFR TTYVNTNDEV VSHPRRIAIH YFKGWFLIDM VAAIPFDLLI
     FRTGSDETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV LFLLMCTFAL IAHWLACIWY
     AIGNVERPYL EPKIGWLDSL GAQLGKHYNG SDPASGPSVQ DKYVTALYFT FSSLTSVGFG
     NVSPNTNSEK VFSICVMLIG SLMYASIFGN VSAIIQRLYS GTARYHTQML RVKEFIRFHQ
     IPNPLRQRLE EYFQHAWSYT NSIDMNAVLK GFPECLQADI CLHLHRALLQ HCPAFRGASK
     GCLRALAVKF KTTHAPPGDT LVHLGDVLST LYFISRGSIE ILRDDVVVAI LGKNDIFGEP
     ISLHARPGKS SADVRALTYC DLHKIQRADL LEVLDMYPAF ADSFWSKLEV TFNLRDAGGG
     LQSSPQPAPG SQDHQGFFLS DNQSAAAPSL SISDASGLWP ELLHQMPPRP RDSPPNPQGD
     PDCWPRELGS RLEQLQAQMN RLESRMSSDL SRILQLLQQP LPQGHTGYIL GAPTSNDLAL
     FPVASTTQSP GTRLPQGGLP PAQVPGCGDL NKCRLKRKNS SSGVPPLVMA TDKILTLSLE
     QEQPEGLLSP LASPLHPLEV QGLICGPRFP SLPERLGPVP KQLEFQRHGS DPGLARS
//
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