ID M3WSM7_FELCA Unreviewed; 103 AA.
AC M3WSM7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Histone H4 {ECO:0000256|ARBA:ARBA00020836, ECO:0000256|RuleBase:RU000528};
GN Name=H4C4 {ECO:0000313|VGNC:VGNC:109942};
GN Synonyms=H4C1 {ECO:0000313|VGNC:VGNC:109938}, H4C11
GN {ECO:0000313|VGNC:VGNC:109943}, H4C12 {ECO:0000313|VGNC:VGNC:109944},
GN H4C13 {ECO:0000313|VGNC:VGNC:109947}, H4C14
GN {ECO:0000313|VGNC:VGNC:109948}, H4C19 {ECO:0000313|VGNC:VGNC:109946},
GN H4C2 {ECO:0000313|VGNC:VGNC:109937}, H4C3
GN {ECO:0000313|VGNC:VGNC:109939}, H4C6 {ECO:0000313|VGNC:VGNC:109941},
GN H4C8 {ECO:0000313|VGNC:VGNC:109940}, H4C9
GN {ECO:0000313|VGNC:VGNC:109945}, LOC123385657
GN {ECO:0000313|Ensembl:ENSFCAP00000042090.1};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000042090.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000042090.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042090.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000042090.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042090.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000042090.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000042090.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC {ECO:0000256|ARBA:ARBA00002001, ECO:0000256|RuleBase:RU000528}.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA. {ECO:0000256|RuleBase:RU000528}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the histone H4 family.
CC {ECO:0000256|ARBA:ARBA00006564, ECO:0000256|RuleBase:RU000528}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04001101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AANG04001280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003985732.1; XM_003985683.2.
DR RefSeq; XP_003985737.1; XM_003985688.4.
DR RefSeq; XP_003985815.1; XM_003985766.4.
DR RefSeq; XP_006931451.1; XM_006931389.3.
DR RefSeq; XP_006931453.1; XM_006931391.2.
DR RefSeq; XP_006931456.1; XM_006931394.3.
DR RefSeq; XP_006933596.1; XM_006933534.2.
DR RefSeq; XP_006935130.1; XM_006935068.3.
DR RefSeq; XP_011278010.1; XM_011279708.2.
DR RefSeq; XP_011280374.1; XM_011282072.2.
DR RefSeq; XP_011280375.1; XM_011282073.2.
DR RefSeq; XP_011280379.1; XM_011282077.2.
DR RefSeq; XP_019687262.1; XM_019831703.1.
DR SMR; M3WSM7; -.
DR STRING; 9685.ENSFCAP00000021135; -.
DR PaxDb; 9685-ENSFCAP00000016486; -.
DR Ensembl; ENSFCAT00000021998.3; ENSFCAP00000021135.1; ENSFCAG00000023368.3.
DR Ensembl; ENSFCAT00000051629.1; ENSFCAP00000049070.1; ENSFCAG00000040479.1.
DR Ensembl; ENSFCAT00000053107.1; ENSFCAP00000051019.1; ENSFCAG00000042515.1.
DR Ensembl; ENSFCAT00000055511.1; ENSFCAP00000048633.1; ENSFCAG00000046199.1.
DR Ensembl; ENSFCAT00000055577.1; ENSFCAP00000042090.1; ENSFCAG00000042402.1.
DR Ensembl; ENSFCAT00000058544.1; ENSFCAP00000046233.1; ENSFCAG00000042793.1.
DR Ensembl; ENSFCAT00000058626.1; ENSFCAP00000047424.1; ENSFCAG00000045765.1.
DR Ensembl; ENSFCAT00000063866.1; ENSFCAP00000045472.1; ENSFCAG00000045635.1.
DR Ensembl; ENSFCAT00000066080.1; ENSFCAP00000044275.1; ENSFCAG00000046263.1.
DR Ensembl; ENSFCAT00000066233.1; ENSFCAP00000044442.1; ENSFCAG00000041451.1.
DR Ensembl; ENSFCAT00000067621.1; ENSFCAP00000061995.1; ENSFCAG00000053116.1.
DR Ensembl; ENSFCAT00000076357.1; ENSFCAP00000058834.1; ENSFCAG00000052647.1.
DR Ensembl; ENSFCAT00000083587.1; ENSFCAP00000055466.1; ENSFCAG00000052591.1.
DR GeneID; 101082491; -.
DR GeneID; 101083921; -.
DR GeneID; 101083933; -.
DR GeneID; 101088423; -.
DR GeneID; 101089767; -.
DR GeneID; 101092762; -.
DR GeneID; 101095347; -.
DR GeneID; 105260538; -.
DR KEGG; fca:101082491; -.
DR KEGG; fca:101083921; -.
DR KEGG; fca:101083933; -.
DR KEGG; fca:101088423; -.
DR KEGG; fca:101089767; -.
DR KEGG; fca:101092762; -.
DR KEGG; fca:101095347; -.
DR KEGG; fca:105260538; -.
DR CTD; 100856216; -.
DR CTD; 121504; -.
DR CTD; 8294; -.
DR CTD; 8361; -.
DR CTD; 8362; -.
DR CTD; 8364; -.
DR CTD; 8368; -.
DR CTD; 8370; -.
DR VGNC; VGNC:109938; H4C1.
DR VGNC; VGNC:109943; H4C11.
DR VGNC; VGNC:109944; H4C12.
DR VGNC; VGNC:109947; H4C13.
DR VGNC; VGNC:109948; H4C14.
DR VGNC; VGNC:109946; H4C19.
DR VGNC; VGNC:109937; H4C2.
DR VGNC; VGNC:109939; H4C3.
DR VGNC; VGNC:109942; H4C4.
DR VGNC; VGNC:109941; H4C6.
DR VGNC; VGNC:109940; H4C8.
DR VGNC; VGNC:109945; H4C9.
DR eggNOG; KOG3467; Eukaryota.
DR GeneTree; ENSGT01060000248528; -.
DR HOGENOM; CLU_109117_2_3_1; -.
DR OMA; RRNRNMS; -.
DR OrthoDB; 4611766at2759; -.
DR Proteomes; UP000011712; Chromosome B2.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000023368; Expressed in tip of external ear and 11 other cell types or tissues.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10484; HISTONE H4; 1.
DR PANTHER; PTHR10484:SF0; HISTONE H4; 1.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU000528};
KW Citrullination {ECO:0000256|ARBA:ARBA00022934};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000528};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleosome core {ECO:0000256|ARBA:ARBA00023269,
KW ECO:0000256|RuleBase:RU000528};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU000528};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 28..93
FT /note="TATA box binding protein associated factor (TAF)
FT histone-like fold"
FT /evidence="ECO:0000259|SMART:SM00803"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 103 AA; 11367 MW; A9E5DFD3F8B97598 CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG
//