ID M3WU99_FELCA Unreviewed; 2438 AA.
AC M3WU99;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Nucleoprotein TPR {ECO:0000256|ARBA:ARBA00019789};
GN Name=TPR {ECO:0000313|Ensembl:ENSFCAP00000017936.2,
GN ECO:0000313|VGNC:VGNC:107957};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017936.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000017936.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017936.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000017936.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017936.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000017936.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017936.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TPR family. {ECO:0000256|ARBA:ARBA00005274}.
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DR EMBL; AANG04001043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9685-ENSFCAP00000017936; -.
DR Ensembl; ENSFCAT00000030676.3; ENSFCAP00000017936.2; ENSFCAG00000030516.4.
DR VGNC; VGNC:107957; TPR.
DR eggNOG; KOG4674; Eukaryota.
DR GeneTree; ENSGT00730000111014; -.
DR HOGENOM; CLU_001059_0_0_1; -.
DR OrthoDB; 3135837at2759; -.
DR Proteomes; UP000011712; Chromosome F1.
DR Bgee; ENSFCAG00000030516; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0034399; C:nuclear periphery; IEA:UniProt.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProt.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.10.287.1490; -; 2.
DR InterPro; IPR012929; TPR/MLP1.
DR PANTHER; PTHR18898:SF2; NUCLEOPROTEIN TPR; 1.
DR PANTHER; PTHR18898; NUCLEOPROTEIN TPR-RELATED; 1.
DR Pfam; PF07926; TPR_MLP1_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 1115..1242
FT /note="Nucleoprotein TPR/MLP1"
FT /evidence="ECO:0000259|Pfam:PF07926"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1695..1750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1880..2200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2302..2438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 105..248
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 295..357
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 397..442
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 503..589
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 619..679
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 741..877
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1297..1492
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1695..1712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1713..1750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1880..1903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1956..1974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1981..2013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2020..2060
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2075..2089
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2096..2145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2146..2165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2302..2335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2371..2400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2438 AA; 274922 MW; E99432A5FA4AD031 CRC64;
MPSSGSVSRS RQRGRPMASR SFDGSRRGSL RRAGAREPRS EVVDAGAQAS GSSWSSPFFS
GSAPPAAGPA APGHIDMAAV LQQVLERTEL NKLPKSVQNK LEKFLADQQS EIDGLKGRHE
KFKVESEQQY FEIEKRLSHS QERLVNETRE CQSLRLELEK LNNQLKALTE KNKELEVAQD
RNIAIQSQFT RTKEELEAEK RDLVRTNERL SQELEYLTED FKRLNEKLKE SNATKGDLQL
KLDELQASDV SVKYREKRLE QEKELLHNQN TWLNTELKTK TDELLALGRE KGNEILELKC
NLENKKEEVS RMEEQMNGLK MSNENLQKHV EELLTKLKEA KEQQASMEEK FHNELNAHIK
LSNLYKSAAD DSEAKSNELT RAVDELHKLL KEAGEANKAI QDHLLEVEES KDQMEKEMLE
KIGKLEKELE NANDLLSATK RKGAILSEEE LAAMSPTAAA VAKIVKPGMK LTELYNAYVE
TQDQLLLEKL ENKRINKYLD EIVKEVEAKA PILKRQREEY ERAQKAVASL SVKLEQAMKE
IQRLQEDTDK ANKHSSVLER DNQRMEIQIK DLSQQIRVLL MELEEARGNH VIRDEEVSSA
DISSSSEVIS QHLVSYRNIE ELQQQNQRLL VALRELGETR EREEQETTSS KITELQLKLE
NALTELEQLR ESRQHQMQLV DSIVRQRDMY RILLSQTTGV AIPLQASSLD DISLASTPKR
SSTSQTASTP APVPVIESAE AIEAKAALKQ LQEIFENYKK EKADNEKIQN EQLEKLQDQI
TDLRSQNTKI STQLDFASKR YEMLQDNVEG YRREITSLHE RNQKLTATTQ KQEQIINTMT
QDLRGANEKL AVAEVRAENL KKEKEMLKLS EVRLSQQRES LLAEQRGQNL LLTNLQTIQG
ILERSETETK QRLSGQIEKL EHEISHLKKK LENEVEQRHT LTRNLDVQLL DTKRQLDTET
NLHHNTKELL KNAQKEIATL KQHLSNMEVQ LASQSSQRTG KGQPSNKEDV DDLLSQLRQA
EEQVNDLKER LKTSTSNVEQ YRAMVTSLEE SLNKEKQVTE EVRKNIEVRL KESAEFQTQL
EKKLMEVEKE KQELQDDKRK AIESMEQQLS ELKKTLNSVQ NEVQEALQRA STALSNEQQA
RRDCQEQAKI AVEAQNKYER ELMLHAADVE ALQAAKEQVS KMASVRQHLE ETTQKAESQL
LECKASWEER ERMLKDEVSK CVSRCEDLEK QNRLLHDQIE KLSDKVVASV KEGVQGPLNV
SLSEEGKSQE QILEILRFIR REKEIAETRF EVAQVESLRY RQRVELLERE LQELQDSLNA
EREKVQVTAK TMAQHEELMK KTETMNVVME TNKMLREEKE RLEQDLQQMQ AKVRKLELDI
LPLQEANAEL SEKSGMLQAE KKLLEEDVKR WKARNQHLVS QQKDPDTEEY RKLLSEKEVH
TKRIQQLTEE IGRLKAEIAR SNASLTNNQN LIQSLKEDLN KVRTEKETIQ KDLDAKIIDI
QEKVKTITQV KKIGRRYKTQ YEELKAQQDK AMETSAQSSG DHQEQHVSVQ EMQELKETLN
QAETKSKSLE SQVENLQKTL SEKETEARNL QEQTVQLQSE LSRLRQDLQD RTTQEEQLRQ
QITEKEEKTR KAIVAAKSKI AHLAGVKDQL TKENEELKQR NGALDQQKDE LDVRMTALKS
QYEGRISRLE RELREHQERH LEQRDEPQEP TTKVPEQQRQ ITLKTTPASG ERGIASTSDP
PTANIKPTPV VSTPSKVTAA AMAGNKSTPR ASIRPMVTPA TVTNPTTTPT ATVMPTTQVE
SQEAMQSEGP VEHVPVFGSA SGSVRSTSPN VQPSIPQPIL TVQQQTQATA FVQPTQQSHP
QIEPANQELS PNIVEVVQSS PVERPSTSTA VFGTVSATPS SSLPKRTREE EEDSTIEASD
QVSDDTVEMP LPKKLKSVTP VGTEEEVMAE ESTDGEVETQ VYNQDSQDSI GEGVTQGDYT
PMEDSEETSQ SLQIDLGPLQ SDQQTTSSQD GQGKGDDVIV IDSDDEEEDD DENDGEHEDY
EEDEEDEDDD EDDTGMGDEG EDSNEGTGSA DGNDGYEADD AEGGDGTDPG TETEESMGGG
ESNQRAADSQ NSGEGNAGTA EPSFSQDVSR EQQPSSASER QTPRAPQSPR RPPHPLPPRL
TIHAPPQELG PPVQRIQMTR RQSVGRGLQL TPGIGGMQQH FFDDEDRTVP STPTLVVPHR
TDGFAEAIHS PQVAGVPRFR FGPPEDMPQT SSSHSDLGQL ASQGGLGMYE TPLFLAHEEE
SGGRSVPTTP LQVAAPVTVF TESTTSDASE HASQSVPMVT TSTGTLSTTN ETATGDDGDE
VFVEAESEGI SSEAGLEIDS QQEEEPVQAS DESDLPSTSQ DPPSSSSVDT SSSQPKPFRR
VRLQTTLRQG VRGRQFNRQR GVSHAMGGRG GINRGNIN
//
