ID M3WW42_FELCA Unreviewed; 150 AA.
AC M3WW42;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Cystatin domain-containing protein {ECO:0000259|Pfam:PF00031};
GN Name=LOC101089343 {ECO:0000313|Ensembl:ENSFCAP00000018579.1};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000018579.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000018579.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018579.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000018579.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018579.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000018579.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018579.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the cystatin family.
CC {ECO:0000256|ARBA:ARBA00009403}.
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DR EMBL; AANG04003379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019683689.1; XM_019828130.1.
DR AlphaFoldDB; M3WW42; -.
DR STRING; 9685.ENSFCAP00000018579; -.
DR PaxDb; 9685-ENSFCAP00000018579; -.
DR Ensembl; ENSFCAT00000029820.4; ENSFCAP00000018579.1; ENSFCAG00000030881.4.
DR GeneID; 101089343; -.
DR KEGG; fca:101089343; -.
DR eggNOG; ENOG502TAJ0; Eukaryota.
DR GeneTree; ENSGT00940000161877; -.
DR HOGENOM; CLU_118168_3_1_1; -.
DR InParanoid; M3WW42; -.
DR OMA; TIGIEHW; -.
DR OrthoDB; 5258835at2759; -.
DR Proteomes; UP000011712; Chromosome A3.
DR Bgee; ENSFCAG00000030881; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0019730; P:antimicrobial humoral response; IBA:GO_Central.
DR Gene3D; 3.10.450.10; -; 1.
DR InterPro; IPR043250; CST9-like.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR PANTHER; PTHR46945; CYSTATIN-9-LIKE; 1.
DR PANTHER; PTHR46945:SF1; CYSTATIN-9-LIKE; 1.
DR Pfam; PF00031; Cystatin; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 1.
PE 3: Inferred from homology;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022704};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Thiol protease inhibitor {ECO:0000256|ARBA:ARBA00022704}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..150
FT /note="Cystatin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004042646"
FT DOMAIN 48..133
FT /note="Cystatin"
FT /evidence="ECO:0000259|Pfam:PF00031"
SQ SEQUENCE 150 AA; 17663 MW; 305E217F7B1B8D18 CRC64;
MGVQVSIVIP NWRCRWALPW AMLLLLLGSE FLEEVESEDE KLTMSYLLAT VEYAIHIFNL
QNNDTNAYRL VRILKPRREQ FKEDSTLAFS FDLQLRRTRC GKFDEDIDNC PFQASSEKNN
IITCFFTIAS EPWLTLFELW NKTCLDGFHK
//
