ID M3WWJ2_FELCA Unreviewed; 231 AA.
AC M3WWJ2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=DNA damage-inducible transcript 4 protein {ECO:0000256|ARBA:ARBA00040168};
GN Name=DDIT4 {ECO:0000313|Ensembl:ENSFCAP00000018731.1,
GN ECO:0000313|VGNC:VGNC:61390};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000018731.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000018731.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018731.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000018731.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018731.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000018731.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018731.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DDIT4 family.
CC {ECO:0000256|ARBA:ARBA00010670}.
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DR EMBL; AANG04000273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003994088.1; XM_003994039.3.
DR RefSeq; XP_006937918.1; XM_006937856.2.
DR AlphaFoldDB; M3WWJ2; -.
DR STRING; 9685.ENSFCAP00000018731; -.
DR PaxDb; 9685-ENSFCAP00000018731; -.
DR Ensembl; ENSFCAT00000022789.4; ENSFCAP00000018731.1; ENSFCAG00000029132.4.
DR GeneID; 101082094; -.
DR KEGG; fca:101082094; -.
DR CTD; 54541; -.
DR VGNC; VGNC:61390; DDIT4.
DR eggNOG; ENOG502RB72; Eukaryota.
DR GeneTree; ENSGT00530000063652; -.
DR HOGENOM; CLU_086145_1_0_1; -.
DR InParanoid; M3WWJ2; -.
DR OMA; MPGLWER; -.
DR OrthoDB; 5383960at2759; -.
DR Proteomes; UP000011712; Chromosome D2.
DR Bgee; ENSFCAG00000029132; Expressed in eyeball of camera-type eye and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0071889; F:14-3-3 protein binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
DR GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR GO; GO:0045820; P:negative regulation of glycolytic process; IEA:Ensembl.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IBA:GO_Central.
DR GO; GO:0032984; P:protein-containing complex disassembly; IEA:Ensembl.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR Gene3D; 3.90.470.40; RTP801-like; 1.
DR InterPro; IPR012918; RTP801-like.
DR InterPro; IPR038281; RTP801-like_C_sf.
DR PANTHER; PTHR12478:SF7; DNA DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN; 1.
DR PANTHER; PTHR12478; DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4; 1.
DR Pfam; PF07809; RTP801_C; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 231 AA; 25113 MW; 79A33F0F3FF818A9 CRC64;
MPSLWDRFSS SSSSSSSSLS RTHTPDQPPR SAWGSAAREE GLGRCASLES SDCESLDSSN
SGFGPEEDSA YLDGVSLPDF ELLSDPEDEH LCANLMQLLQ ESLSQARLGS RRPARLLMPS
QLVSQVGKEL LRLAYSEPCG LRGALLDVCV EQGKSCHSVG QLALDPSLVP TFQLTLVLRL
DSRLWPKIQG LFSSANSPFV PGFSQSLTLS TGFRVIKKKL YSSEQLLIEE C
//
