ID M3WX81_FELCA Unreviewed; 904 AA.
AC M3WX81;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Regulator of G protein signaling 3 {ECO:0000313|Ensembl:ENSFCAP00000018970.4};
GN Name=RGS3 {ECO:0000313|Ensembl:ENSFCAP00000018970.4,
GN ECO:0000313|VGNC:VGNC:82500};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000018970.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000018970.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018970.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000018970.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018970.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000018970.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018970.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04004382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011286784.1; XM_011288482.2.
DR AlphaFoldDB; M3WX81; -.
DR STRING; 9685.ENSFCAP00000018970; -.
DR PaxDb; 9685-ENSFCAP00000018970; -.
DR Ensembl; ENSFCAT00000024420.4; ENSFCAP00000018970.4; ENSFCAG00000023166.4.
DR GeneID; 101097523; -.
DR KEGG; fca:101097523; -.
DR CTD; 5998; -.
DR VGNC; VGNC:82500; RGS3.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00940000154416; -.
DR HOGENOM; CLU_005574_0_0_1; -.
DR InParanoid; M3WX81; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000011712; Chromosome D4.
DR Bgee; ENSFCAG00000023166; Expressed in spleen and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030695; F:GTPase regulator activity; IEA:UniProt.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd08713; RGS_RGS3; 1.
DR Gene3D; 1.10.196.10; -; 2.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR034951; RGS_RGS3.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR46848; REGULATOR OF G-PROTEIN SIGNALING 3; 1.
DR PANTHER; PTHR46848:SF1; REGULATOR OF G-PROTEIN SIGNALING 3; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 18..95
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 779..895
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 389..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..506
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..611
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 100026 MW; FCAF48F6D2BEF67E CRC64;
MNRFNGLCKV CSERRYRQIT IPRGKDGFGF TICCDSPVRV QAVDSGGPAE RAGLQQLDTV
LQLNERPVEH WKCVELAHEI RSCPSEIILL VWRMVPQVKP GPDGGVLRRA SCKSTHDLQS
PPNKREKNCT HGAQARPEQR HSCHLVCDSS DGLLLGGWER YTEVAKRGGQ HTLPALSRAT
ASTDPNYIIL APLNPGSQLL RPLYQEDAIP EESGGPSKGK SYTGLGKKSR LMKTVQTMKG
HGNYQNCPVM RPHTPHSSYG TYVTLAPKVL VFPVFVQPLD LCNPARTLLL SEELLLYEGR
NKAVEVTLFA YSDLLLFTKE DEPGRCNVLR NPLYLQSVKL QEGSSEDLKF CVLYLAEKAE
CLFTLEAHSQ EQKKRVCWCL SENIAKQQQL AASPPESKMF EPEADEKREM PLEEGKELGA
EDPPPNKDPS SGQEPPSGQD FPPNKESSSV QEPSPGQEPL SSKDSPSCKE PPPGQEPWPS
KDSPPCQEPP ALPPCQDLPT SQEPPPSQDP QVSQDLPVIR DPPAQELEPC QDQVPLPAEE
TTSSGDPPAA PGDLPVASRP AFVIPEVRLD SAYSQKAGAE GGGLGFEEDA EEAEEGDEGD
EEEEEEDTSD DNYGEHHEAK RSSMIEAGQA AEGGLSLRVQ NSLRRRTHSE GSLLQEARGP
CFASDTTLHC SDGEGTASTW AMPSPRTLKK ELGRNGGSMH HLSLFFTGHR KMSGADAVGD
DDEASRKRKS KNLAKDMKNK LGIFRRRNES PGAQPGGKAD KMVKSFKPTS EEALKWGESL
EKLLLHKYGL AVFQAFLRTE FSEENLEFWL ACEDFKKVKS QSKMTAKAKK IFAEYIAIQA
CKEVNLDSYT REHTKDNLQS VTRGCFDLAQ KRIFGLMEKD SYPRFLRSDL YLDLINQKKM
SPPL
//
