ID M3WZJ1_FELCA Unreviewed; 596 AA.
AC M3WZJ1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Kallikrein B1 {ECO:0000313|Ensembl:ENSFCAP00000019782.4};
GN Name=KLKB1 {ECO:0000313|Ensembl:ENSFCAP00000019782.4,
GN ECO:0000313|VGNC:VGNC:67969};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000019782.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000019782.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019782.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000019782.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019782.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000019782.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019782.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AANG04002583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WZJ1; -.
DR MEROPS; S01.212; -.
DR Ensembl; ENSFCAT00000023150.4; ENSFCAP00000019782.4; ENSFCAG00000031525.4.
DR VGNC; VGNC:67969; KLKB1.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT00940000161669; -.
DR HOGENOM; CLU_031604_0_0_1; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000031525; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd01100; APPLE_Factor_XI_like; 4.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF00024; PAN_1; 4.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00005; APPLEDOMAIN.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00223; APPLE; 4.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00495; APPLE; 1.
DR PROSITE; PS50948; PAN; 3.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Serine protease {ECO:0000256|RuleBase:RU363034}.
FT DOMAIN 73..156
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 163..246
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 254..337
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 353..588
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 596 AA; 66532 MW; E5D3D107D43498B1 CRC64;
MYTPNAEHCQ MMCTFHPRCL LFSFLPESST NDTDKRFGCF LKDSVTGTLP KMSWANTISG
HSLKQCGHQI SACHRDIHEG IDMRGVNFNV SRVESVEECQ KKCTNSIHCQ FFTYATRTFY
DAEYRNTCLL KHSAGGTPTS IKLLANVASG FSLKPCALSE IGCRRSIFQH LAFSDVDVAR
VVTPDAFVCQ TICTYHPNCL FFTFHTKAWH LEPQRNVCFL KTSKSGTPSS PTPQENTVSG
YSLLTCKQSL PEPCHSKIYS GVAFEGEELN VTFVEGVNVC QETCTETIRC QFFTYSLLPE
DCRRKKCKCS LRLSLDGSPT RITYGTRASS GYSLRLCKSG DGSACSTKTD TRIVGGTNSS
WGEWPWQVSL QVKLTARSHL CGGSIIGHQW VLTAAHCFDG LPLQDVWRVY SGIFNLSEIT
TETPFSRIKE MIIHPNYKMS DSGDDLALIR LEPPLNYTEF QKPICLPSKD DTNTMYTNCW
VTGWGFTKEK GKIQNTLQKA NVPLVSSEEC QKKYRDYEVT KQMICAGYKE GGKDACKGDS
GGPLVCKHNG IWHLVGITSW GEGCGRREQP GVYTKVAEYV DWILEKTQVG DGLTSL
//
