ID M3X0Z7_FELCA Unreviewed; 609 AA.
AC M3X0Z7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Translocase of outer mitochondrial membrane 70 {ECO:0000313|Ensembl:ENSFCAP00000020289.1};
GN Name=TOMM70 {ECO:0000313|Ensembl:ENSFCAP00000020289.1,
GN ECO:0000313|VGNC:VGNC:66446};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000020289.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000020289.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000020289.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000020289.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000020289.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000020289.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000020289.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004572}.
CC -!- SIMILARITY: Belongs to the Tom70 family.
CC {ECO:0000256|ARBA:ARBA00038030}.
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DR EMBL; AANG04001815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003991631.1; XM_003991582.4.
DR AlphaFoldDB; M3X0Z7; -.
DR STRING; 9685.ENSFCAP00000020289; -.
DR PaxDb; 9685-ENSFCAP00000020289; -.
DR Ensembl; ENSFCAT00000030186.4; ENSFCAP00000020289.1; ENSFCAG00000030491.4.
DR GeneID; 101093292; -.
DR KEGG; fca:101093292; -.
DR CTD; 9868; -.
DR VGNC; VGNC:66446; TOMM70.
DR eggNOG; KOG0547; Eukaryota.
DR GeneTree; ENSGT00940000157095; -.
DR HOGENOM; CLU_017516_2_0_1; -.
DR InParanoid; M3X0Z7; -.
DR OMA; QWRGDIE; -.
DR OrthoDB; 1083789at2759; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000030491; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0002218; P:activation of innate immune response; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46208; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR PANTHER; PTHR46208:SF1; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13181; TPR_8; 4.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 115..148
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 368..401
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 402..435
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 477..510
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 546..579
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 67..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67376 MW; A16C637C336AE0C8 CRC64;
MAASKPVEAA VVAAAAPSSG SGVGGGGATA GPGTGGLPRW QLALAVGAPL LLGAGAMYLW
SRQRRRREAG GRGDAGGLKR NSERKTPEGR ASPAPGSGHP DGSGAHLEMN SLDRAQAAKN
KGNKYFKAGK YEQAIQCYTE AISLCPIEKN ADLSTFYQNR AAAFEQLQKW KEVAQDCTKA
VELNPKYVKA LFRRAKAHEK LDNKKECLED VTAVCILEGF QNQQSMLLAD KVLKLLGKEK
AKEKYKNREP LMPSPQFIKS YFSSFTDDII SQPMLKGEKS DEDKDKEGEA SEVKENSGYL
RAKQYMEEEN YDKIISECSK EIDAQGKYMA EALLLRATFY LLIGNANAAK PDLDKVISLK
EANVKLRANA LIKRGSMYMQ QQQPLLSTQD FNMAADIDPQ NADVYHHRGQ LKILLDQVEE
AVADFDECIR LRPESALAQA QKCFALYRQA YTGNNSSQIQ AAMKGFEEVI KKFPRCAEGY
ALYAQALTDQ QQFGKADDMY DKCIDLEPDN ATTYVHKGLL QLQWKQDLDR GLELISKAIE
IDNKCDFAYE TMGTIEVQRG NMEKAIDMFN KAINLAKSEM EMAHLYSLCD AAHAQTEVAK
KYGLKPPTL
//
