ID M3X431_FELCA Unreviewed; 1082 AA.
AC M3X431;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=MTSS I-BAR domain containing 2 {ECO:0000313|Ensembl:ENSFCAP00000021381.4};
GN Name=MTSS2 {ECO:0000313|Ensembl:ENSFCAP00000021381.4,
GN ECO:0000313|VGNC:VGNC:63661};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000021381.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000021381.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021381.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000021381.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021381.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000021381.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021381.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3X431; -.
DR STRING; 9685.ENSFCAP00000021381; -.
DR Ensembl; ENSFCAT00000024617.4; ENSFCAP00000021381.4; ENSFCAG00000030321.4.
DR VGNC; VGNC:63661; MTSS2.
DR eggNOG; ENOG502QRG4; Eukaryota.
DR GeneTree; ENSGT00950000183156; -.
DR HOGENOM; CLU_004805_2_1_1; -.
DR InParanoid; M3X431; -.
DR OMA; WRSISHI; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000030321; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0030031; P:cell projection assembly; IBA:GO_Central.
DR GO; GO:0061024; P:membrane organization; IBA:GO_Central.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR CDD; cd07643; I-BAR_IMD_MIM; 1.
DR CDD; cd22060; WH2_MTSS1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR030127; MTSS1/MTSS2.
DR PANTHER; PTHR15708; ACTIN BUNDLING/MISSING IN METASTASIS-RELATED; 1.
DR PANTHER; PTHR15708:SF8; PROTEIN MTSS 2; 1.
DR Pfam; PF08397; IMD; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51338; IMD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 375..628
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT REGION 68..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..271
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..308
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1082 AA; 115791 MW; BFC7E34226DF53A5 CRC64;
MSSQVALGVV PGVWEKELCE LFPSGPPARV GFPAWSLQDD RPYWTRRPRE HACVPTHVYP
GVGDWGRQPT SAQLVQHPPP LPSKQVARPG NDYPKSSAWR PSCERLRHRL KERPKSFWRS
VRTRQCPGRN VPGRADARAS PAVCRVSRPR DAPGGAQPSA RPPKAREDPG PRPRAGRWCR
APSREAGTQP PVLSRQAAGR APPQRRPRPV VAPAPAGPAR PATLAAPGLE FQSRAPALNG
PAPGRPFPQP SPAAAPPTPP PPRPAAVLPP PHPRDARAAA ARITAAAPVP APRPRRQLPA
PRPPRRPPAP PRHGPRRPAA ARHPGAPRGR PLSAARRRRP GPASERAPAA PGSLGCRRPA
PLPAPAVAAA ARPGPSMETA EKECGALGGL FQAIVNDMKS SYPIWEDFNS KATKLHSQLR
TTVLAAVAFL DAFQKVADMA TNTRGATRDI GSALTRMCMR HRSIETKLRQ FTNALLESLI
NPLQERIEDW KKSANQLDKD HAKEYKRARH EIKKKSSDTL KLQKKARKEL LGKGDLQPQL
DSALQDVNDM YLLLEETEKQ AVRRALIEER GRFCTFITFL QPVVNGELTM LGEITHLQGI
IDDLVVLTAE PHKLPPASEQ VIKDLKGSDY SWSYQTPPSS PSGSGSRKSS MCSLAQPAAT
TARLSSVSSH DSGFVSQDAT YSKPPSPMPS DITSQKSSSS ASSEASETCQ SVSECSSPTS
DWAKAGPHEQ PSGTSLQRRK DRLEHPRDTE PGLASGGTLG PSGEEAPRPR MSPATIAAKH
GEEVSPAASD LAMVLTRGLS LEHQKSSRDS LQYSSGYSTQ TTTPSCSEDT IPSQGSDYDC
YSVNGDADGE GPAEFDKSST IPRNSNIAQN YRRLIQTKRP ASTAGLPSAS GAPPGVATIR
RTPSTKPAVR RALSSAGPIP IRPPIVPVKT PTVPDSPGYA GPTRAGSEEC VFYSDEAASP
LAPDLAKASP KRLSLPNTAW ASPAPEAASY PGLADDDEQQ QLAANRHSLV EKLGELVAGA
HALGEGQFPF PTALTATPAE ETPSPPPAAS GDPPAEDMLV AIRRGVRLRR TVTNDRSAPR
IL
//
