ID M3X4F3_FELCA Unreviewed; 456 AA.
AC M3X4F3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Splicing factor 3a subunit 2 {ECO:0000313|Ensembl:ENSFCAP00000021503.4};
GN Name=SF3A2 {ECO:0000313|Ensembl:ENSFCAP00000021503.4,
GN ECO:0000313|VGNC:VGNC:65053};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000021503.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000021503.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021503.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000021503.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021503.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000021503.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021503.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SF3A2 family.
CC {ECO:0000256|ARBA:ARBA00008995}.
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DR EMBL; AANG04002859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3X4F3; -.
DR STRING; 9685.ENSFCAP00000021503; -.
DR Ensembl; ENSFCAT00000028522.4; ENSFCAP00000021503.4; ENSFCAG00000030476.4.
DR VGNC; VGNC:65053; SF3A2.
DR eggNOG; KOG0227; Eukaryota.
DR GeneTree; ENSGT00720000108823; -.
DR HOGENOM; CLU_050757_1_1_1; -.
DR InParanoid; M3X4F3; -.
DR OMA; SREGMPH; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000030476; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; IEA:Ensembl.
DR GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR GO; GO:1903241; P:U2-type prespliceosome assembly; IEA:Ensembl.
DR Gene3D; 2.60.40.2690; -; 1.
DR InterPro; IPR000690; Matrin/U1-C_Znf_C2H2.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR031781; SF3A2_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23205; SPLICING FACTOR 3A SUBUNIT 2; 1.
DR PANTHER; PTHR23205:SF0; SPLICING FACTOR 3A SUBUNIT 2; 1.
DR Pfam; PF16835; SF3A2; 1.
DR Pfam; PF12874; zf-met; 1.
DR SMART; SM01050; CactinC_cactus; 1.
DR SMART; SM00451; ZnF_U1; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS50171; ZF_MATRIN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 54..84
FT /note="Matrin-type"
FT /evidence="ECO:0000259|PROSITE:PS50171"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..369
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..456
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 48495 MW; 4B2AF1EA1B4C322F CRC64;
MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH LGSYECKLCL
TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE KVKVEVKKFV KIGRPGYKVT
KQRDTEMGQQ SLLFQIDYPE IAEGVMPRHR FMSAYEQRIE PPDRRWQYLL MAAEPYETIA
FKVPSREIDK AEGKFWTHWN RETKQFFLQF HFKMEKPPAP PSLPAGPPGV KRPPPPLMNG
LPPRPPLPES LPPPPPGGLP LPPMPPSGPA PSGPPGPPQL PPPAPGVHPP TSGVHPPAPG
VHPPAPGVHP PTPVVHPPAS GVHPPAGVHP PAPGVHPPAP GVHPPPSAGV HPQAPGVHPP
APAVHPQAPG VHPAAPAVHP QAPGVHPPAP GVHPPAPGIH PQPPGVHPPA PGVHPQPPGV
HPSNPGVHPP TPMPPMLRPP LPSEGPGNIP PPPPAN
//
