ID M3X4T2_FELCA Unreviewed; 588 AA.
AC M3X4T2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Zinc finger protein 599 {ECO:0000313|Ensembl:ENSFCAP00000021632.3};
GN Name=ZNF599 {ECO:0000313|Ensembl:ENSFCAP00000021632.3};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000021632.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000021632.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021632.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000021632.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021632.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000021632.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021632.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04004572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003997989.1; XM_003997940.4.
DR AlphaFoldDB; M3X4T2; -.
DR PaxDb; 9685-ENSFCAP00000021632; -.
DR Ensembl; ENSFCAT00000029643.3; ENSFCAP00000021632.3; ENSFCAG00000031530.3.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159953; -.
DR HOGENOM; CLU_1411735_0_0_1; -.
DR InParanoid; M3X4T2; -.
DR OMA; QSTCAGE; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000031530; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR19818:SF162; ZINC FINGER PROTEIN 728-LIKE; 1.
DR PANTHER; PTHR19818; ZINC FINGER PROTEIN ZIC AND GLI; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 9..80
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 199..226
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 227..254
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 255..282
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 283..310
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 311..338
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 339..366
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 367..394
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 395..422
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 423..450
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 451..478
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 479..506
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 507..534
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 535..562
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 563..588
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 101..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 67499 MW; 5030F8A5D763BBFA CRC64;
MAAPALALVS FEDVAVTFTG EEWRQLDLAQ RTLYQEVMLE TCGLLVSLGH PVPKPELIYP
LEPGQELWTG KRGVSKSTCT GEKAKPETTE FTASQLAFTE EAPFEEQMTQ GASRDSRLGQ
ARDREKLSEM QEGNLRPGTD PHEETCPRKL SHKHDDLETD DSLCLTILQE RVTIQDDLHE
HDCQGPRKDP VTDARNNLYK CKECGKGFSK NWALVRHQQI HAGVKPYKCS ECGKACRYMA
DFIRHTRFHT GEKPYKCVEC GKAFKRRSHL TEHQRIHTGD KPYECKECGK AFTHRSSFIQ
HNMTHTREKP FLCKECGKAF YYSSSFAQHM RIHTGKKLYE CSECGKAFTH RSTFIQHNMT
HTGEKPFLCK ECGKAFCLNS SFIQHMRIHT GEKPYACSEC GKAFTHRSTF VRHKRTHTGE
KPFQCKECGK AFCDSSSLIQ HMRIHTGERP YECSECGKAF THHSVFIRHN RTHTGEKPLE
CKQCAKAFYY SSSFTRHMRI HTGEKPYVCR ECGKAFTQPA NFVRHNRIHT GEKPYECKDC
KKAFCDNFAL TQHTRTHTGE KPFECGVCGK TFSHSSSFTH HRKIHTRV
//