ID M3X5H9_FELCA Unreviewed; 560 AA.
AC M3X5H9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Coatomer subunit epsilon {ECO:0000256|ARBA:ARBA00015828};
DE AltName: Full=Epsilon-coat protein {ECO:0000256|ARBA:ARBA00031602};
GN Name=CERS1 {ECO:0000313|VGNC:VGNC:80020};
GN Synonyms=COPE {ECO:0000313|Ensembl:ENSFCAP00000021880.4};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000021880.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000021880.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021880.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000021880.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021880.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000021880.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000021880.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. The coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC In mammals, the coatomer can only be recruited by membranes associated
CC with ADP-ribosylation factors (ARFs), which are small GTP-binding
CC proteins; the complex also influences the Golgi structural integrity,
CC as well as the processing, activity, and endocytic recycling of LDL
CC receptors. {ECO:0000256|ARBA:ARBA00025440}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|ARBA:ARBA00011775}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPI-coated vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004347}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004347}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004347}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004255}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the COPE family.
CC {ECO:0000256|ARBA:ARBA00008827}.
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DR EMBL; AANG04000016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3X5H9; -.
DR STRING; 9685.ENSFCAP00000021880; -.
DR Ensembl; ENSFCAT00000024254.4; ENSFCAP00000021880.4; ENSFCAG00000023920.4.
DR VGNC; VGNC:80020; CERS1.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00390000003478; -.
DR HOGENOM; CLU_020515_4_0_1; -.
DR InParanoid; M3X5H9; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000023920; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0030126; C:COPI vesicle coat; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR006822; Coatomer_esu.
DR InterPro; IPR006634; TLC-dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10805; COATOMER SUBUNIT EPSILON; 1.
DR PANTHER; PTHR10805:SF0; COATOMER SUBUNIT EPSILON; 1.
DR Pfam; PF04733; Coatomer_E; 1.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR SMART; SM00724; TLC; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50922; TLC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00205}; Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00205};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 316..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 307..521
FT /note="TLC"
FT /evidence="ECO:0000259|PROSITE:PS50922"
FT REGION 537..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 63676 MW; D57F21D15F6E203A CRC64;
MAPPAPVSAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKPSSPGRDV ERDVFLYRAY
LAQRKYGVVL DEIKPSSAPE LQAVRMFAEY LANDSQRDSI VAELDREMSR SVDVTNTTFL
LMAASIYFHD QNPDAALRAL HQGDSLECMA MTVQILLKLD RLDLARKELK KMQDQDEDAT
LTQLATAWVN LAVGGDKLQD AYYIFQEMAD KCSSTLLLLN GQAACHMAQG RWEAAEGVLQ
EALDKDSGHP ETLINLIVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY QAKPLAKRCR
LQPRDAAKMP ESAWKFLFYL GAWSYSAYLL FGTDYPFFHD PPSVFYDWTS GMAVPRDIAA
AYLLQGSFYG HSIYATLYMD AWRKDSVVML VHHVVTLVLI VSSYAFRYHN VGILVLFLHD
ISDVQLEFTK LNVYFKSRGG SHHRLHALAS DLGCLSFCLS WFWFRLYWFP LKVLYATCHC
SLRSVPDIPF YFFFNALLLL LTLMNLYWFL YIVAFAAKVL TGQVRELKDV REYDAAEAQS
PKAGKAEKPL RNGLVRDKRF
//
