ID M3X638_FELCA Unreviewed; 815 AA.
AC M3X638;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=RAB GTPase activating protein 1 like {ECO:0000313|Ensembl:ENSFCAP00000022089.3};
GN Name=RABGAP1L {ECO:0000313|Ensembl:ENSFCAP00000022089.3};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000022089.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000022089.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022089.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000022089.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022089.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000022089.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022089.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04001043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003999262.1; XM_003999213.3.
DR AlphaFoldDB; M3X638; -.
DR STRING; 9685.ENSFCAP00000022089; -.
DR PaxDb; 9685-ENSFCAP00000022089; -.
DR Ensembl; ENSFCAT00000027599.4; ENSFCAP00000022089.3; ENSFCAG00000026642.4.
DR eggNOG; KOG1102; Eukaryota.
DR GeneTree; ENSGT00940000154611; -.
DR HOGENOM; CLU_007394_1_1_1; -.
DR InParanoid; M3X638; -.
DR OMA; XDSAQES; -.
DR Proteomes; UP000011712; Chromosome F1.
DR Bgee; ENSFCAG00000026642; Expressed in brain and 10 other cell types or tissues.
DR CDD; cd01211; PTB_Rab6GAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF7; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 136..251
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 538..724
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 30..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 92542 MW; A489A1C7DEF9ADF1 CRC64;
MEVRASLQKV SGSSDSVATL NSEEFVLVSQ HADDTSTKDD EKPELKIVSN GDEQLEKAME
EILRDSEKGQ SSPLADCQSS SESSDHSFGD VSASQTNKPS LQLILDPSNT EISTPRPSSL
SGLPEEDSVL FNKLTYLGCM KVSSPRNEVE ALRAMATMKS SSQHPFPVTL YVPNVPEGSV
RIIDQSSNVE IASFPIYKVL FCARGHDGTT ESNCVAFTES SHGSEEFQIH VFSCEIKEAV
SRILYSFCTA FKRSSRQVSD VKDSVIPTPD SDVFTFSVSL EVKEDDGKGN FSPVPKDREK
FYFKLKQGIE KKVVITVQQL SNKELAIERC FGMLLSPGRN VKNSDMHLLD MESMGKSYDG
RAYVITGIWN PNVPIFLALN EETPKDKRVY MTVAVDMVVT EVVEPVRFLL ETVVRVYPPN
ERFWYFSRKT FTETFFMRLK QYEGKGHTNA GDAIYEVVSL QRQSEKEEPV TPTSGGGPMS
PQEDEAEEES DNELSSGTGD VSKDCPEKIL YSWGELLGRW HNNLGARPKG LSTLVKSGVP
EALRAEVWQL LSGCHDNQTM LDRYRLLITK DSAQESVITR DIHRTFPAHD YFKDTGGDGQ
ESLYKICKAY SVYDEDIGYC QGQSFLAAVL LLHMPEEQAF CVLVKIMYDY GLRDLYKNNF
EDLHCKFYQL ERLMQEQLPD LHTHFCDLHL EAHMYASQWF LTLFTAKFPL CMVFHIIDLL
LCEGLNIIFH VALALLKTSK EDLLQADFEG ALKFFRVQLP KRYRAEENAR RLMEQACNIK
VPTKKLKKYE KEYQTMRESQ LQQEDPMDRY KFVYL
//
