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Database: UniProt
Entry: M3X680_FELCA
LinkDB: M3X680_FELCA
Original site: M3X680_FELCA 
ID   M3X680_FELCA            Unreviewed;      1869 AA.
AC   M3X680;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 42.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN3A {ECO:0000313|Ensembl:ENSFCAP00000022132};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000022132, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000022132, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022132,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000022132}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022132};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000022132}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022132};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AANG03018953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03018954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03018955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03018956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03018957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000022132; -.
DR   Ensembl; ENSFCAT00000029888; ENSFCAP00000022132; ENSFCAG00000024761.
DR   eggNOG; ENOG410KCTY; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3X680; -.
DR   OMA; EGCIKKF; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C1.
DR   Bgee; ENSFCAG00000024761; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1869       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5014127220.
FT   TRANSMEM    119    139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    269    296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    630    648       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    660    683       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    740    768       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    830    853       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1076   1094       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1115   1137       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1143   1163       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1192   1218       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1313   1337       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1396   1414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1426   1444       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1451   1476       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1513   1541       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1617   1640       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    303       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      376    579       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      630    858       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      867   1069       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1074   1345       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1395   1650       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      293    334       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1869 AA;  211700 MW;  E6B242581EC97EC5 CRC64;
     MLIMCTILTN CVFMTLSNPP DWTKNVEYTF TGIYTFESLI KILARGFCLE DFTFLRDPWN
     WLDFSVIVMA YVTEFVDLGN VSALRTFRVL RALKTISVIP GLKTIVGALI QSVKKLSDVM
     ILTVFCLSVF ALIGLQLFMG NLRNKCLQWP PSDSAFETNT TSYFNGTMDS NGIFVNVTMS
     TFNWKDYIED DSHFYVLDGQ KDPLLCGNGS DAGQCPEGYI CVKAGRNPNY GYTSFDTFSW
     AFLSLFRLMT QDYWENLYQL TLRAAGKTYM IFFVLVIFLG SFYLVNLILA VVAMAYEEQN
     QATLEEAEQK EAEFQQMLEQ LKKQQEEAQA VAAASAASRD FSGIGGLGEL LESSSEASKL
     SSKSAKEWRN RRKKRRQREH LEGNNKGEGD RFPKSESEDS VKRRSFLFSM DGNRLTSDKK
     FYSPHQSLLS IRGSLFSPRR NSKTSIFSFR GRAKDVGSEN DFADDEHSTF EDSESRRDSL
     FVPHRHGERR NSNVSQASMS SRMVPGLPAN GKMHSTVDCN GVVSLVGGPS ALTSPTGQLL
     PEGTTTETEV RKRRLSSYQI SMEMLEDSSG RQRAMSIASI LTNTMEELEE SRQKCPPCWY
     RFANVFLIWD CCDAWLKVKH LVNLIVMDPF VDLAITICIV LNTLFMAMEH YPMTGQFSSV
     LTVGNLVFTG IFTAEMVLKI IAMDPYYYFQ EGWNIFDGII VSLSLMELGL ANVEGLSVLR
     SFRLLRVFKL AKSWPTLNML IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM QLFGKSYKEC
     VCKISSDCQL PRWHMNDFFH SFLIVFRVLC GEWIETMWDC MEVAGQTMCL IVFMLVMVIG
     NLVVLNLFLA LLLSSFSSDN LAATDDDNEM NNLQIAVGRM QKGIDYVKSK IRECFRKTFF
     RKPKVIEVHE GNKIDSCISN NTGIEISKEL NYLKDGNGTT SGVGTGSSVE KYVIDENDYM
     SFINNPSLTV TVPIAVGESD FENLNTEEFS SESELEESKE KLNATSSSEG STVDVAPPRE
     GEQAEMEPEE DLKPEACFTE GCIKKFPFCQ VSIEEGKGKV WWNLRKTCYS IVEHNWFETF
     IVFMILLSSG ALAFEDIYIE QRKTIKTMLE YADKVFTYIF ILEMLLKWVA YGFQTYFTNA
     WCWLDFLIVD VSLVSLVANA LGYSELGAIK SLRTLRALRP LRALSRFEGM RVVVNALVGA
     IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF YHCVNTTTGN MFEVSEVNNL SDCQALGKQA
     RWKNVKVNFD NVGAGYLALL QVATFKGWMD IMYAAVDSRD VKLQPVYEEN LYMYLYFVIF
     IIFGSFFTLN LFIGVIIDNF NQQKKKFGGQ DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP
     ANKFQGMVFD FVTRQVFDIS IMILICLNMV TMMVETDDQS KYMTLVLSRI NLVFIILFTG
     EFVLKLVSLR YYYFTIGWNI FDFVVVILSI VGMFLAELIE KYFVSPTLFR VIRLARIGRI
     LRLIKGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYAI FGMSNFAYVK KEAGIDDMFN
     FETFGNSMIC LFQITTSAGW DGLLAPILNS APPDCDPDTI HPGSSVKGDC GNPSVGIFFF
     VSYIIISFLV VVNMYIAVIL ENFSVATEES AEPLSEDDFE MFYEVWEKFD PDATQFIEFS
     KLSDFAAALD PPLLIAKPNK VQLIAMDLPM VSGDRIHCLD ILFAFTKRVL GESGEMDALR
     IQMEDRFMAS NPSKVSYEPI TTTLKRKQEE VSAAIIQRNF RCYLLRQRLK KVSSEYNKEA
     IKGRIDLPIK EDMIIDKLNG NSTPEKTDGS SSTTSPPSYD SVTKPDKEKF EKDKPEKESK
     GKEVRETQK
//
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