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Database: UniProt
Entry: M3X7P6_FELCA
LinkDB: M3X7P6_FELCA
Original site: M3X7P6_FELCA 
ID   M3X7P6_FELCA            Unreviewed;      4961 AA.
AC   M3X7P6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   20-JUN-2018, entry version 45.
DE   SubName: Full=SCO-spondin {ECO:0000313|Ensembl:ENSFCAP00000022648};
GN   Name=SSPO {ECO:0000313|Ensembl:ENSFCAP00000022648};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000022648, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000022648, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022648,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000022648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022648};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000022648}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022648};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR   EMBL; AANG03024327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03024328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03024329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03024330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000022648; -.
DR   Ensembl; ENSFCAT00000024510; ENSFCAP00000022648; ENSFCAG00000021965.
DR   eggNOG; KOG1215; Eukaryota.
DR   eggNOG; KOG1216; Eukaryota.
DR   eggNOG; KOG4475; Eukaryota.
DR   eggNOG; ENOG410XNSK; LUCA.
DR   GeneTree; ENSGT00760000118896; -.
DR   InParanoid; M3X7P6; -.
DR   OMA; MQTKNEL; -.
DR   OrthoDB; EOG091G0006; -.
DR   Proteomes; UP000011712; Chromosome A2.
DR   Bgee; ENSFCAG00000021965; -.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   CDD; cd00112; LDLa; 7.
DR   Gene3D; 2.20.100.10; -; 24.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR030119; SCO-spondin.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339:SF358; PTHR11339:SF358; 24.
DR   Pfam; PF08742; C8; 3.
DR   Pfam; PF00057; Ldl_recept_a; 7.
DR   Pfam; PF01826; TIL; 12.
DR   Pfam; PF00090; TSP_1; 22.
DR   Pfam; PF00093; VWC; 1.
DR   Pfam; PF00094; VWD; 3.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00832; C8; 3.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00181; EGF; 7.
DR   SMART; SM00192; LDLa; 9.
DR   SMART; SM00209; TSP1; 25.
DR   SMART; SM00214; VWC; 6.
DR   SMART; SM00215; VWC_out; 8.
DR   SMART; SM00216; VWD; 2.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF57424; SSF57424; 8.
DR   SUPFAM; SSF57567; SSF57567; 14.
DR   SUPFAM; SSF82895; SSF82895; 24.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS01209; LDLRA_1; 4.
DR   PROSITE; PS50068; LDLRA_2; 9.
DR   PROSITE; PS50092; TSP1; 25.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 2.
DR   PROSITE; PS51233; VWFD; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
KW   ECO:0000256|SAAS:SAAS00895822};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   4961       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014116041.
FT   DOMAIN      142    261       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      427    637       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      878   1084       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     1796   1856       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1896   2053       F5/8 type C. {ECO:0000259|PROSITE:
FT                                PS50022}.
FT   DOMAIN     4805   4861       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     4860   4954       CTCK. {ECO:0000259|PROSITE:PS01225}.
FT   DISULFID   1261   1276       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1281   1293       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1288   1306       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1300   1315       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1317   1329       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1324   1342       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1336   1351       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1357   1369       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1364   1382       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1472   1487       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   1508   1526       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2061   2073       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2068   2086       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2080   2095       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2206   2218       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2213   2231       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2225   2240       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2263   2275       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2270   2288       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2282   2297       {ECO:0000256|PROSITE-ProRule:PRU00124}.
SQ   SEQUENCE   4961 AA;  525495 MW;  340D503A150C5F65 CRC64;
     MLLPALLFGM AWALANGRWC ERTETFLVEE EVTPRQEGLV PCTSLYHYQR LGWRLDLSRR
     GPAGLCPIYK PPETRPAARN RTVTACCPGW GGTHCTLALA EASPGGHCFA TQQCQLQPGS
     AHASAGSLEE LGSVTPSFSC PGLSLQWQGD WLVLSGGLGV VVQLDRSGSV SVSVDYELQG
     QTQGLCGVYS GRPEDDFLEP GGRLAVLAAT FGNSWRLPDS EPGCLDAVEA AQGCEDPVRG
     TEAGMEAGQL EAEAQDVCHQ LLESPFRECH AQVPPAEYHQ TCLFAYCSGA PAGSGRESRQ
     EAVCTTLANY AQECAKHHIH VGWRKPGFCE RLCPGGQLYS DCASACPPSC SAVGEGGEGS
     CQEACVSGCE CPPGLFWDGA LCVPAARCPC YHRRQRYAPG DTVRQLCNPC VCQDGRWLCA
     QAQCPAECAV GGDGHYVTFD GRSFSFRGSP GCRSSLVQDF SKGQLLIVLE HGACDAGSCL
     HAISVSLGDT HIQLRDSGAI LVDGQDVGLP WSGPKGLSVS RASSTFLLLR WPGAQVLWGV
     SDPAAYITLD PRHAHQVQGL CGTFTWNQQD DFLTPAGDVE TSVAAFASKF RVAGEGRCPS
     EDSAPLPPCS THSQRHVFAE AACAILHGPT FQECQGLVDR ELFHLRCLAA VCGCAPGKDC
     LCPVLAAFAR RCAREGVPSL WRTQTLCPVL CPGGQEYQEC APACGQNCGE PEDCGELGSC
     VAGCNCPPGL LWDPEGECVP PNLCSCQLGT QRYAPGSATM RDCNHCVCQE RGLWNCTAHR
     CGPQRTFCPH ELVYVPGACL LTCDNMRANH SCPPDSTGSC VCPPGTVLLN ERCVPPELCP
     CRHGGQWYPP NATIQEDCNI CVCQGRQWHC TSRQCRGWCQ ASGAPHYVTF DGLAFTFPGA
     CEYLLVREAS GQFTVSAQNL PCGASGLTCT KALTVQLQST VVHMLRGRAV MVNGASITLP
     KVYTGPGLSL RRAGLFLLLT TRLGFSLFWD GGTRVLVQLS PHFRGRVSGL CGDFDGDASN
     DLRSRQGVLE PTAELAAHSW HLNPLCPEPG ELPHPCTVNA HRASWAHAHC GVMLQSLFAR
     CHAEVPPQQH YERCVHDACG CDSGGDCECL CSAIATYADE CARHGLFVRW RSQELCPLQC
     EGGQVYEACG PICPPTCHDH GPEPGWHCQA VACVEGCFCP EGTLLHGGVC LEPASCPCES
     GGSFFPPGTV LQKDCGNCTC QESQWLCGSG RTRCEEPVPG CVEGEAPCQE SGHCVPHGWL
     CDNQDDCGDG SDEEGCATPG CGEGQMSCSS GRCLPLALLC DGSDDCGDGT DEQGCPCPHD
     SLACADGRCL PPALLCDGHP DCPDAADEEA CLGQLNCTPG EVSCVDGTCV GAILLCDGTW
     DCPDGADEGP GHCPFLSLPT PPAGTLPGPS AGSGETAPTP LASASPENCS PEAWDRRDTL
     WVPTGSTQLP PCDGLFSCGL APQLCLSPEQ LCDGISDCSQ GEDELGCEGM TAPGGPNGTR
     VPCPEYSCPD GLCISFQLVC DGQPDCELAG TAGPSPEEQG CGAWSPWDPW GPCSRTCGPG
     VQARSRRCSP PSLPVLQHCP GPEHQTQACF TAACPVDGEW TSWSPWSPCS EPCTGTMTRQ
     RQCHPPQNGG RTCTTLPGGS HATHQTRPCP RDGCLNATCS GQLVFWPCAP CPLTCDEVSG
     GAVCSADQPC SSPGCWCPAG QVLGSEGQCV WPRQCPCLVD GTRYWPGQRI KASCQLCILN
     CGWSSWSPWA ECLGPCGSQS IQWSFRSPNN PRLSGQGRQC RGIHRKARRC QTEPCEGCEQ
     RGRVRGVGER WREGPCRVCQ CLHNSTVRCS PYCPLGGCPQ DWVLVEGMGD LCCHCALPGE
     NQTILAMATP APSPALSPQI GPRLVTYVLP PPGDPCYSPL GLAGLPRENL QLELPTQAAL
     LGAPTRGPGY RGRSTIENTR TQRHTLPPYL QLDLLLPRNL TGIIVQETGS LALLQFSTDG
     LHWHNYSDIL PGILPPAKSP LFLQLFLKNL DEVAPTVWMF GQMVQTQHVR VWPRVPHSDT
     NHSTSPWVEL LGLSPLVAPL CPGAGHRCAS GECAPRGGPC DGVKDCEDGS DEEGCVPLPA
     DTGRYGCPAQ PWRGQPRERW ELEGLTSLLP APTGKGPVTQ VPDSEAPRLS PRESVQTMTT
     PPTSQPEAKA LRPGTTAMTE LPLHPMSPVA PAGQSVAPPP FPPAQCSPGQ VPCEVLGCVE
     REQLCDGRED CLDGSDERRC ASAAPFPVPT TALPGLPASK ALCSPSQLSC DSGECLPAER
     RCDLRPDCQD GSDEDGCVDC GLAPWSGWSS CSRSCGLGLA FQRRDLLRPP LPGGTCPSDR
     LRSQPCFVQA CPVAGVWAVW EAWGPCSVSC GGGHRSRRRS CVDPPPKNGG APCPGASQER
     APCGLQPCTG DTDCGLGRVH ISAELCQKGL VPPCPPSCLD PEANRTCSGR CLEGCRCPPG
     LLLHDGRCLP LSECPCLVGE EVKQPGVPFL LDNCSRCVCE KGALVCEPGG CPVSCGWSAW
     SSWGPCDRSC GSGVRTRFRS PSNPPAASGG ALCEGNRQEL QACHVECGTE TLGWTLWEPW
     SSCSRSCLTL GGGPGWRSRS RLCPSPEDNS CPGVATQEEP CSPPVCPAES IWGLWAPWST
     CSAPCDGGIQ IRGRSCSGST PGDPECQGPH SQTRDCNTQP CTAQCPGDMV FRSAEQCRRD
     GGPCPQLCLA QDPGVECTSF CAPGCACLPG LFLHNASCLP RSRCPCQLHG QLYAPGAVAR
     LDSCNNCTCI SGEMVCTSEP CPVACGWSPW TPWSLCSHSC NVGIRRRFRA GTAPPAAFGG
     AACQGPNMEA EFCSLRPCRG PRGEWGPWSP CSVPCGGGYR NRTRGSGPHS LVDFSTCGLQ
     PCAGPVPGVC PGGQRWLDCA QGPASCAELS VLQGADQTCH PGCYCPPGTF LLNNVCVPSQ
     DCPCAHGGRL YPPGSVVLRP CENCSCVSGL ITNCTSWPCE EGQPAWSPWT PWSECSASCG
     PARRHRHRFC TRPPTAEPPI LGLPSPLTLP TPLCPGSDAE EEPCLLAACD RAGGWGPWGP
     WSSCSRSCGG GLRSRMRACD QPPPQGLGDY CEGPRAQGEA CQALPCPVTN CTTIQGAEYS
     PCGPPCPRSC DDLVHCVWHC QPGCYCPPGQ VLSADGDFCV QPSHCGCLDL LSGERHRPGA
     RLLRPDGCNY CTCSEGRLSC TDLPCPVPGG WCPWSEWTAC SQPCRGQTRT RSRACACPAP
     QHGGAPCPGE AGEAGAQHQK ETCPSSPECP VDGAWSPWGL WSSCDACLGQ SHRSRVCIWP
     PTPEGGRPCP GGHRQSRPCQ DNSTKCTECG GGQGLLPCGR PCPRSCQDLS PGSACQPGST
     GCQPSCGCPP GRLFQDGLCV PPALCRCQYQ PGAMGIPENQ SRSAGSGLSS WESLEPGEMV
     TGPCDNCTCM EGVLQCQEVP SCPGPGVWGS WGPWEDCSVS CGGGEQLRSR RCARPPCPGP
     ARQSRTCRTQ VCREAGCPAG RLYRECRPGE GCPFSCAHVT RQVGCFSTGC EEGCHCPEGT
     FQHHLSCVQE CPCVLTALLL QELGAAGTDP GPHSPILGEG GQPLGPGDEL GSGQTLRTGC
     SNCSCVHGRL SCSVGNCSKA ADGFSPWGPW GPCSRSCGGL GTRTRSRQCV QASLAPGSQG
     CRGTRQELKY CPSPDCPGAG GSTVEPVTSL PGSWGPWSPW SPCSRTCTDP AQPAWRGRAR
     LCLANCTGGD TSQERPCNLP SCTELPLCPS PGCVAGNCSW TAWAPWEPCS RSCGVGQQRR
     LRAYHPPGPG GHWCPDILTA YQEHRFCSLR ACPGPGRVLP CPWSWCDRSC GGGRSLRSRS
     CSSPPPKNGG APCVGERHHV RLCNPGPCEQ GCPAGMEMVS CANRCPRRCS DLQEGVVCQD
     GQACQPGCRC SEGFLEQDGG CVPIGHCECT DAQGHSWAPG SQHREACRTC TCRAGQLSCT
     AQPCPPPAHC AWSRWSAWSP CSHSCGPGGQ QSRFRSSTSG SWAPECREEQ SQSRPCPQPP
     CPPLCLHGAR LHTLGDSWLQ GECQQCSCTP EGIICEDIEC AVPRAWTLWS PWSECPVSCG
     GGNQVRTRDC VASTPHRSGA PCLGPGTQTQ SCGRQPCLGL LDACSWGPWG PCSHSCGPGL
     ASRSGSCPCP LARADPTCNS TFLHLDTQAC YRGPCLEECV WSSWSSWTRC SCRVLVQQRY
     RHQGPGPGGA GTGAGPPCTR LDGHFRPCPL GNCSEDSCTP PFEFQACGSP CAGLCATHLS
     RRLCQDLPPC QPGCYCPEGL LEQAGGCIPP EQCSCLHITG EGARVTLAPG DRLQLGCKEC
     ECRRGELKCT SQGCQGLLPL SGWSEWSPCG PCLPPGVLAP ASRTALEERR SQHPAGLSPT
     LAPLLASEQH RHRLCLDPET GRPWAGDPDL CIAPLSQQRL CPDPRACHDL CQWSPWGPWS
     PCQVSCSGGF RLRWREAGGP PGGGCWGPWA QTESCNVEPC PGESCEAQDT VPTLDCANQC
     PRSCVDLWDR VQCLQGPCRP GCRCPPGQLV QDGRCVPISS CRCGLPSPNA SWVVAPDEVV
     QLDCKNCTCT NGSLVCPRHE CPVLGPWSAW SSCSAPCGGG SMGRRRSCEE GPMGVPCQAQ
     DTEQQQECNP QPCPECPPGQ VPSACAASCP HLCSNLQPGA LCVQEPCRLG CGCPGEQLLH
     NGTCVPPAAC PCTQISLPWG LTLTLEEQAR ELPPGTVLTW NCTRCICQDG AFNCSPADCR
     ECPSGEMWQQ VAPGEPGPCE RTCREPNATE TQGSCGVGQA PGCVCQHGHF RSQAGPCVPI
     DHCECWHHGR PHPPGSEWQE ACESCRCLRG RSVCTQHCPL LTCAQGEVTV QEPGSCCPTC
     QGQAASCRHL TELRNVTKGA CYLDQVEVSY CSGHCPSSIS VMPEEPYLQS QCDCCSYSLD
     PENPVRVLHL RCPDGHAEPV VLPAIRSCQC SACQGGDFSK H
//
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