ID M3X919_FELCA Unreviewed; 678 AA.
AC M3X919;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=ERI1 exoribonuclease family member 2 {ECO:0000313|Ensembl:ENSFCAP00000023121.2};
GN Name=ERI2 {ECO:0000313|Ensembl:ENSFCAP00000023121.2,
GN ECO:0000313|VGNC:VGNC:61944};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000023121.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000023121.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023121.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000023121.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023121.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000023121.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023121.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the ERI2 family.
CC {ECO:0000256|ARBA:ARBA00038042}.
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DR EMBL; AANG04001668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003998835.2; XM_003998786.4.
DR AlphaFoldDB; M3X919; -.
DR STRING; 9685.ENSFCAP00000023121; -.
DR PaxDb; 9685-ENSFCAP00000023121; -.
DR Ensembl; ENSFCAT00000024416.4; ENSFCAP00000023121.2; ENSFCAG00000030704.4.
DR GeneID; 101082712; -.
DR KEGG; fca:101082712; -.
DR CTD; 112479; -.
DR VGNC; VGNC:61944; ERI2.
DR eggNOG; KOG0542; Eukaryota.
DR GeneTree; ENSGT00530000063205; -.
DR HOGENOM; CLU_037266_4_0_1; -.
DR InParanoid; M3X919; -.
DR OMA; RAFFCCP; -.
DR OrthoDB; 443016at2759; -.
DR Proteomes; UP000011712; Chromosome E3.
DR Bgee; ENSFCAG00000030704; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR CDD; cd06133; ERI-1_3'hExo_like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR047201; ERI-1_3'hExo-like.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR010666; Znf_GRF.
DR PANTHER; PTHR23044; 3'-5' EXONUCLEASE ERI1-RELATED; 1.
DR PANTHER; PTHR23044:SF78; ERI1 EXORIBONUCLEASE 2; 1.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF06839; zf-GRF; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51999; ZF_GRF; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01343}.
FT DOMAIN 584..630
FT /note="GRF-type"
FT /evidence="ECO:0000259|PROSITE:PS51999"
SQ SEQUENCE 678 AA; 75701 MW; 957099DA48986715 CRC64;
MATKRLARQL GLIRRKSVAP TNGNVGRSKS KQLFDYLIVI DFESTCWNDG KRHQSQEIIE
FPAVLLSTST GEIESEFHTY VQPQEHPILS EFCMELTGIK QAQVDEGVPL RICLSQFCKW
IQKIQQQKKI IFATGISDLS NSEVKLCAFV TWSDWDLGVC LEYECKRKQL LKPVFLNSWI
DLRVTYKIFY RRKPKGLSGA LQEVGIEFLG REHSGLDDSR NTALLAWKMI RDGCLMKITR
SLNKVPTKKN PKILARNLNT NQVEEASACN SSIWGLSTYD REPKNTVNSH EKVQLRSAGV
NSPIKGQDQF QLKSNVKVGL HGGKGYLSLF NTKPSTSLEQ LQSPSLNTPM QKHIKNEHLA
FSTKPKSSTV SSELVLISTT ISSVNHISDM EMSSALDCLP MLADWEDVAL LPASQPEQNI
DCIPPINDSN LDTSLNSIER LMILKEGTEE TPQNSETSKS IVYKSPHTTI YHVKDAKDQG
SVASDFKLPE CKSSSSNSIN ASMSHPSVLG KYPLLLGSTK RNPSSLPAFP PAKKQSFTIH
EEKPTSPDGF PVRSCSQKVL PSVLASTVNL EGSWKSGKMT PPLCKCGRRS KRLVVSNNGP
NHGKVFFCCP NGKYQENRKC CGYFKWEQTL RKERANSSIL SHSPGGPTFS SPEISHICDR
NVNFSTKNSL RLRPSMRN
//
