ID M3X9R1_FELCA Unreviewed; 1070 AA.
AC M3X9R1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=TBC1 domain family member 8B {ECO:0000313|Ensembl:ENSFCAP00000023364.2};
GN Name=TBC1D8B {ECO:0000313|Ensembl:ENSFCAP00000023364.2,
GN ECO:0000313|VGNC:VGNC:65990};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000023364.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000023364.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023364.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000023364.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023364.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000023364.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023364.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04001034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019679688.1; XM_019824129.1.
DR AlphaFoldDB; M3X9R1; -.
DR Ensembl; ENSFCAT00000022868.4; ENSFCAP00000023364.2; ENSFCAG00000022098.4.
DR VGNC; VGNC:65990; TBC1D8B.
DR GeneTree; ENSGT00940000159451; -.
DR OrthoDB; 3034081at2759; -.
DR Proteomes; UP000011712; Chromosome X.
DR Bgee; ENSFCAG00000022098; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd13350; PH-GRAM1_TBC1D8B; 1.
DR CDD; cd13352; PH-GRAM2_TBC1D8B; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR036012; TBC1D8B_PH-GRAM1.
DR InterPro; IPR036015; TBC1D8B_PH-GRAM2.
DR PANTHER; PTHR47666; PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47666:SF1; PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC; 1.
DR Pfam; PF02893; GRAM; 2.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00568; GRAM; 2.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 437..624
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 808..843
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 993..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1070 AA; 122861 MW; 6B3FF8B43084BE04 CRC64;
MWLKPEEVLL KNALKLWLME RSNDYFVLQR RRGYGEEGGG GLTGLLVGTL DSVLDSTAKV
APFRILHQTP DSQVYLSIAC GANREEITKH WDWLEQNIMK TLSVFDSNED ITNFVQGKIR
GLIAEEGKHS FAKEDDPEKF REALLKFEKC FGLPEQEKLV TYYSCSYWKG RVPCQGWLYL
STNFLSFYSF LLGSEIKLVI SWDAVSKLEK TSNVILTESI HVCSQGENHY FSMFLHINET
YLLMEQLANY AIKRLFDKET FANDPILDDP LQITKRGLEN RAHSEQFSAF FRLPKEEALK
EVHECCLWIP FSHFNTHGKM CISENYICFA SQDGSLCSII IPLREVLAID KTNDSTKTVI
ISIKGKTAFR FSEVKDFEQL VAKFRLKCRA ASAPYHDIST ELKEKMKEQS WNILFTECGR
GVSMFRTKKT RDLVVRGIPE TLRGELWMLF SGAVNEMAAN PGYYAEVVEQ SLGTCNLATE
EIERDLRRSL PEHPAFQSDT GISALRRVLT AYAYRNPKIG YCQAMNILTS VLLLYAKEEE
AFWLLVAVCE RMLPDYFNHR IIGALVDQAV FEELIRDHFP QLTERMTDMT FFSSVSLSWF
LTLFISVLPI ESAVNVVDCF FYDGIKAILQ LGLAILDYNL DKLITCKDDA EAVTTLNRFF
DSVTNKDSPL PSSVQQGSNV SDEKSSLIKV DITDLIRESN EKYGNIRYED IHSLRCRNRL
YVIQTLEETT KQNVLRVVSQ DVKLSLHELD ELYVIFKKEL FFSYYWCLGC PVLKYHDPSL
PYLEQYQIDC QQFRVLYHLL SPWAHSANKD SLALWTFRLL DENSDCLINF KEFSSAIDTM
YNGSFTDKLK LLFKLHIPPA YTEVKSKDPS KGDELSKEDL LYFSQLHVSQ PINVKEAESL
KKSPEKGKGK VDIQAYLSQW QDELSKKEES IKDLPRMNQS QFIQFSKTLY NLFHGDPEEE
SLYQAIAVVT SLLLRMEEVG RKLHSPTASA KEFSGTVCAS GGPSEGKTES HLKKDPSSLR
EELQWSFAFE QILASLLNEP ALVRFFERPI DVKVKLENAK TSQLSFRTKM
//