ID M3XBA9_FELCA Unreviewed; 360 AA.
AC M3XBA9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=Epoxide hydrolase 3 {ECO:0000313|Ensembl:ENSFCAP00000023913.1};
GN Name=EPHX3 {ECO:0000313|Ensembl:ENSFCAP00000023913.1,
GN ECO:0000313|VGNC:VGNC:80027};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000023913.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000023913.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023913.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000023913.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023913.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000023913.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023913.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Epoxide hydrolase
CC family. {ECO:0000256|ARBA:ARBA00038334}.
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DR EMBL; AANG04002574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003982020.1; XM_003981971.4.
DR AlphaFoldDB; M3XBA9; -.
DR STRING; 9685.ENSFCAP00000023913; -.
DR MEROPS; S33.978; -.
DR PaxDb; 9685-ENSFCAP00000023913; -.
DR Ensembl; ENSFCAT00000032383.4; ENSFCAP00000023913.1; ENSFCAG00000028947.4.
DR GeneID; 101099782; -.
DR KEGG; fca:101099782; -.
DR CTD; 79852; -.
DR VGNC; VGNC:80027; EPHX3.
DR eggNOG; KOG4178; Eukaryota.
DR GeneTree; ENSGT00940000162086; -.
DR HOGENOM; CLU_020336_7_3_1; -.
DR InParanoid; M3XBA9; -.
DR OMA; EEMHQYM; -.
DR OrthoDB; 2443908at2759; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000028947; Expressed in tip of external ear and 10 other cell types or tissues.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004301; F:epoxide hydrolase activity; IEA:Ensembl.
DR GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR GO; GO:0097176; P:epoxide metabolic process; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR PANTHER; PTHR43329; EPOXIDE HYDROLASE; 1.
DR PANTHER; PTHR43329:SF10; EPOXIDE HYDROLASE 3; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..339
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 360 AA; 40941 MW; BEF7436EBDD66198 CRC64;
MPELVVTALL APSRVTLKLL RAFMWSLVFC AALLTAAVYG CIALTHVLCR PRRGCCGRPR
RTPPACLSDP TLGEHCFLTL KSSGLRLHYV SAGRGNGPLM LFLHGFPENW FSWRYQLWEF
QSRFHVVAVD LRGYGSSDAP RDVDCYTIDL LMVDIQDVIL GLGYSKCILV AHDWGAVLAW
NFSIYYPSLV ERMVVVSAAP MSVYQDYSTH HISQFFRSNY VFLFQLPWLP EKLLSMSDFQ
ILKTTLTHRK RGIPHLTPNE LEAFLYDFSQ PGGLTGPLNY YRNLFRNLPL EPQELATPTL
LLWGEKDTYL EQGLVGAISS RFVPGRLEAH ILPGVGHWIP QSNPEEMHQY MWAFLQDLLG
//
