ID M3XCN3_FELCA Unreviewed; 393 AA.
AC M3XCN3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Signal transducing adaptor family member 2 {ECO:0000313|Ensembl:ENSFCAP00000024389.4};
GN Name=STAP2 {ECO:0000313|VGNC:VGNC:65749};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000024389.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000024389.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024389.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000024389.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024389.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000024389.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024389.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XCN3; -.
DR STRING; 9685.ENSFCAP00000024389; -.
DR Ensembl; ENSFCAT00000027256.4; ENSFCAP00000024389.4; ENSFCAG00000021949.4.
DR VGNC; VGNC:65749; STAP2.
DR eggNOG; ENOG502QURW; Eukaryota.
DR GeneTree; ENSGT00530000063841; -.
DR HOGENOM; CLU_043957_0_0_1; -.
DR InParanoid; M3XCN3; -.
DR OMA; SQLPPCY; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000021949; Expressed in tip of external ear and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR CDD; cd13268; PH_Brdg1; 1.
DR CDD; cd10404; SH2_STAP2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR039111; STAP1/STAP2.
DR InterPro; IPR035878; STAP2_SH2.
DR PANTHER; PTHR16186:SF11; SIGNAL-TRANSDUCING ADAPTOR PROTEIN 2; 1.
DR PANTHER; PTHR16186; SIGNAL-TRANSDUCING ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 19..118
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 156..233
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 330..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 43614 MW; 84F63C0CA3788B36 CRC64;
MASALSPPRV PKPKGALPSH YYENFLEKKG PCDRDYKKFW AGLKGCTLYF YNSNRDSQHV
EKLDLTALVK LTDDPPWGSS RDPGIHFSLV LRNQEIKFKV ESLESREMWK GFILTVVELR
IPSNLTLLPG HLYMMAEALA KEEARRALEV PSCFLKVSRL EAQLLLERYP ECGNLLLRPS
GDGTGGVSVT TRQTLNGSSV VRHYKVKHEG PKYVIDVEEP FSCDSLDAVV NYFVTRTKKS
LVPFLPDEDY EKVLGYVEAD NENGESVWLA PPAPRGPAPV SSPNKLTPLP NEDENYVIPI
AHTPAATYVN GDVPSSSRPV IRKLKKVAKV QAKPPKLPKP PIAPKPEPQG LNGGLAKKLA
GNSAQAFFPT TGLADLTAEL EEKLRRRRAL EHS
//
