ID M3XCX5_FELCA Unreviewed; 790 AA.
AC M3XCX5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN Name=HECTD2 {ECO:0000313|Ensembl:ENSFCAP00000024481.4,
GN ECO:0000313|VGNC:VGNC:62783};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000024481.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000024481.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024481.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000024481.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024481.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000024481.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024481.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04000273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XCX5; -.
DR STRING; 9685.ENSFCAP00000024481; -.
DR Ensembl; ENSFCAT00000025594.4; ENSFCAP00000024481.4; ENSFCAG00000022061.4.
DR VGNC; VGNC:62783; HECTD2.
DR eggNOG; KOG0941; Eukaryota.
DR GeneTree; ENSGT00940000157750; -.
DR HOGENOM; CLU_002173_5_0_1; -.
DR InParanoid; M3XCX5; -.
DR OMA; FSSFKCE; -.
DR Proteomes; UP000011712; Chromosome D2.
DR Bgee; ENSFCAG00000022061; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 451..790
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 758
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 790 AA; 90021 MW; 5D7DBD6D60C8EFB3 CRC64;
MSEAGRVPSP AAPPEVAAAA PDERKGKEPE REKLPPIVSA GAGATAGLDR GSKGQISTFS
SFVSTVNQKK EAAENRSSPT HLVFPNIKNV RDLPPICLDV RQKQRISTEA SSSEMKAPVL
PEPVLPNQPK TMKDFQEDTE KAKSSGDWKA VHDFYLTTFD SFPELNAAFK KDATTSFNTI
EDSGINAKFV NAVYDALLNT PQDIQKTVLK GIINSLLREW KGPRTKDDLR AYFILLQNPQ
FNNTSTYVIY AHLLRQIATL VEADHHFLVH WFKKLSQKRF KQLVERLLQF ISLRLFPAKP
EEFPPITKCS WWIPSASKVL SLLNTANSLV HPPLIPYTDF YNSTLDHIDL MEEYHTWQSF
GNSHSTSASW FWCRPYFHRF SFCQYPFVIS IAAKKIIIQR DSEQQMISIA RQSLVDKVSR
RQRPDMNMLF LNMKVRRTHL VSDSLDELTR KRADLKKKLK VTFVGEAGLD MGGLTKEWFL
LLIRQIFHPD YGMFTYHKDS HCHWFSSFKC DNYSEFRLVG ILMGLAVYNS ITLDIRFPPC
CYKKLLSPPI IPSDQNTPVG ICSVTTDDLC QIMPELAHGL SELLSYEGNV EEDFYSTFQV
FQEEFGIIKS YNLKPGGDKI PVTNQNRKEY VQLYVDFLLN KSIYKQFAAF YYGFHSVCAS
NALMLLRPEE VEILVCGSPE LDMHALQRST QYDGYAKTDL TIRYFWDVVL GFPLDLQKKL
LHFTTGSDRV PVGGMADLNF KISKNETSTN WLPVAHTCFN QLCLPPYKSK KDLKQKLIIG
ISNSEGFGLE
//
