ID M3XDW3_FELCA Unreviewed; 1000 AA.
AC M3XDW3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Sorting nexin 19 {ECO:0000313|Ensembl:ENSFCAP00000024819.3};
GN Name=SNX19 {ECO:0000313|Ensembl:ENSFCAP00000024819.3,
GN ECO:0000313|VGNC:VGNC:65549};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000024819.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000024819.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024819.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000024819.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024819.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000024819.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024819.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AANG04002871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XDW3; -.
DR STRING; 9685.ENSFCAP00000024819; -.
DR PaxDb; 9685-ENSFCAP00000024819; -.
DR Ensembl; ENSFCAT00000029001.4; ENSFCAP00000024819.3; ENSFCAG00000032007.4.
DR VGNC; VGNC:65549; SNX19.
DR eggNOG; ENOG502QQBH; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_012033_0_0_1; -.
DR InParanoid; M3XDW3; -.
DR OMA; QPSQLWE; -.
DR Proteomes; UP000011712; Chromosome D1.
DR Bgee; ENSFCAG00000032007; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:1990502; P:dense core granule maturation; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR CDD; cd06893; PX_SNX19; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037909; SNX19_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF31; SORTING NEXIN-19; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..273
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 541..671
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 418..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 110357 MW; 36EE9940FE6A28E2 CRC64;
MKAETVTSLQ ETPAESSWSL SNLLSSRKLM TVGIVLGWLM VIHFLVNVWL LCLLSALLAV
LGGWLGSNAI VGASGRLHLE RFIPVATCPP NPEAERQLEQ EINRTIQMII RDFVFSWYRS
VSQEPAFEEE MEAAMRGLVQ ELRRRMGMVD SHALVQRVLT LCGCHLQSYI QAKEATAEKQ
SGTVEPSQLW EAYCRATAPH PAVQSPSTEV TYTRGIVNLL LQGLVPKPHL ETRTGRHVVV
ELITCNVILP LISKLSDPDW IHLVLVGIFS KARNNPTGVV KPTSPASALE KPSVPTSLPL
IVEVQSLPEV RASSPAAAPV LLNCSEPEGP SHHSPEVEEG HEAIEGELGG VPEERKVGNN
ASHFLQPDIR GPLFLCEELE SPLSELSKET IMLMTPGNFL SDRIQDALCA LEGPQSLESK
NVEASEGIEG AEAEEGPGTE TEAGLLVSML TSCPEIHIDT ADKEVEQGDV TSLTALLTDP
ERTCPPRPSC LEKDLTNGVS SLDPSLPQVL LSSSPPGPVS SATFSFEPLS SPDGPVVIQN
LRITGTITAR EHSGTGFHPY TLYTVKYETA LDGENSSGLQ QLAYHTVNRR YREFLNLQTR
LEEKSDLRKF IKNVKGPKKL FPDLPFGNMD SDRVEARKSL LESFLKQLCA IPEIANSEEM
QEFLALNTDA RIAFVKKPFM VSRIDKMVVS AIVDTLKTAF PRSEPQSPTE ELSEAETESK
PQTEGKKTSK SRLRFSSSKI APALNITEAP EKILYCFQEG SVESEILSMS GMESFIEKQT
KLLEMQPAEV PEKDREQIPK GCVDGYLSDP AVPAQDLSTS DPGTETELAD TALDLLLLLL
MEQWRWLCTE NMQKVLRLVF GTLIQRWLEV QVANLTCPQR WVQYLQLLQE SIWPGGVLPK
YPRPVRTQEQ KVAAEKQALQ SLMGILPDIV VEILGVNKCQ LSWSLVLESL QQPVINRHLI
YCLWDIILEF LDLSASVEES TITTSASDTP GNPRRMGVSP
//
