ID M3XGY9_LATCH Unreviewed; 1590 AA.
AC M3XGY9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Tensin 1 {ECO:0000313|Ensembl:ENSLACP00000021995.1};
GN Name=TNS1 {ECO:0000313|Ensembl:ENSLACP00000021995.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000021995.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000021995.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
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DR EMBL; AFYH01090043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01090052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLACT00000025728.1; ENSLACP00000021995.1; ENSLACG00000010269.2.
DR GeneTree; ENSGT00940000155400; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000010269; Expressed in pectoral fin and 6 other cell types or tissues.
DR CDD; cd14560; PTP_tensin-1; 1.
DR CDD; cd09927; SH2_Tensin_like; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035012; Tensin-like_SH2.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR45734; TENSIN; 1.
DR PANTHER; PTHR45734:SF3; TENSIN-1; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 34..206
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 211..337
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 1480..1589
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1110..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1277..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1380..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1344..1360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1412..1445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1590 AA; 171837 MW; AFEB9C5DA070CB1C CRC64;
MPWKWSSMTL HKGSTKSSKS AQSRHRPSRS LSLIQAMEES HDLDLIYITE RIISVSFSTS
ADEQTYRSNL KEVAQMLKSK HGDNYLLFNL SEKRNDISKL NPKVLDFGWP DLHAPALDKI
CSICKAMDTW LNSDPHNVVV IHNKGNQGRT GVVIAAYMHY SNISASADQA LDRFAMKRFY
EDKVVPVGQP SQKRYVHYFS GLLSGTIKMN NKPLFLHHVI MHGIPNFESK GGCRPFLRIY
QSLQPVYTSG IYNVQGDSQT SICITIEPGL LLKGDILLKC YHKKFRSPTR DVMFRVQFHT
CAIHDLGIIF GKEDLDEAFK DDRFPEYGKV EFVFSYGPEK IQGMEHLENG PSVSVDYNTA
DPLIRWDSYD NFNAQCEDGM EEVGHTQGPL DGSLYAKVKK KDSAHGSTST INANGIPLSA
APNHIEHTLS VSSDSGNSTA STKTDKTDEQ PPAAAQQPPI TQPLTPEEKR ELDRLLSGFG
LETEVPMHNR GPGLGTSVGV RHVVPAQVHV NGISVTLAAE RETDILDDDL PNHDGHSVGS
LGTLSSLDGT VNTSEAGGYH EPPKVENSSG FPNGPASSLN GIEKMQADGL YPMETMINGT
YPYDNKNTFR NITSSDRFPQ EDQMRTSISA QEHLTDYQQH LAPNWQQQQQ QQQLDHNGMY
RSQSFPAPEI SRYEAMPKMP QAPARGGSSR EAVQRGLNAW QQQGMPSSGS RPPSRQKDTA
LDSLSPSSVS TTQPRSTLEA MPQSHSIPEF PKMASQQEIE ESIEALNMLM LDLDPSFSQL
HKSQSVPVAA NLKEDHMGAA VAPLSSQPMS NTYSYSIPQR PANAFSPSTG TSMANTSTPS
LVTAEPASSF HPLGGVAQVS RGVGDEAVMH DFREVPATGL HPSYGYAVQH PPAIPIRSYS
RGPGSTSSSP IPPVPPYPSM VPQQQQSAVL SAMPPTPLAQ SHIPTKGPED YETPIKGNEE
EHYNLEGLVA HRVASVQSHT MAPEETGVMT RRRTTSEGQY ENNPQNPNAV RGTTVVRSPV
RCVSPEVVNT IALNPGGRPR EPHMHSYKEA FEEIDGTLPS PTSSGARSPP GLAKTPLSAL
GLKPHNPADI LLQQSGPEPR SYVESVARTA AVGGGGPQSP QMPQGYSGDT PVRNGVHTGP
FASPNPLSTS SPIHSMDGAS LVSFPSAGSS GRTGTPTQTS MDTSFRSVSL SHPSAMDSSY
QNATPSMYSL PGTGSSIGSY MGPDYSMSPT GPQQENHMGP QVNVVGVHII PGSPHTLHRT
VATNTPPSPG LARRMANSNM AASPGSPSMS RHPVGAHVSM SGTPGSPSLG RHPGMIGGSA
PGTPGSPSMD RHPMYGYSAP EERHPTLSRQ SSASGYQPPS TPLFPVSPAY YHGVSSPGIA
SPSPMDASTL RQGSPALQPA LPEKRRMSSE DRSNSMPNYA TVNGKTSSPI SSGMSSPSGG
STPSVAFPHT LPDFSKFSMP DGSPETRANV KFVQDTSKYW YKPEISREQA ITLLKEREPG
AFIIRDSHSF RGAYGLAMKV ATPPPTIVQQ NKKGDMTNEL VRHFLIETSP KGVKLKGCPN
EPYFGCLSAL VYQHSITPLA LPCKLVIPSR
//
