ID M3XHK1_LATCH Unreviewed; 1276 AA.
AC M3XHK1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Peroxidasin like {ECO:0000313|Ensembl:ENSLACP00000022207.1};
GN Name=PXDNL {ECO:0000313|Ensembl:ENSLACP00000022207.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022207.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000022207.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01079266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01079267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01079268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01079269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01079270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01079271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01079272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01079273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01079274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01079275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XHK1; -.
DR STRING; 7897.ENSLACP00000022207; -.
DR Ensembl; ENSLACT00000025329.1; ENSLACP00000022207.1; ENSLACG00000014500.2.
DR eggNOG; KOG2408; Eukaryota.
DR GeneTree; ENSGT00940000163562; -.
DR InParanoid; M3XHK1; -.
DR OMA; EFICHAS; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd09826; peroxidasin_like; 1.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR034824; Peroxidasin_peroxidase.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF38; OXIDOREDUCTASE PXDNL-RELATED; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 40..128
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 136..221
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 226..313
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 318..405
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1206..1264
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT BINDING 867
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 1276 AA; 143190 MW; C968EDD5A937662B CRC64;
MKEYGNSGNT QAAATCEYPR RLQGRSVAAV TAEEFNCERP RITSEPQGVD VTPGNTVYFT
CRAEGNPKPE IIWLHNNHAL DMKDDTRLNL LEDGTLMIQD TRETDQGTYQ CMAKNVAGEA
KTQGVELRYF GSPTKPSFVI QPQNTEVLVG ASITLECSAT GHPQPRITWT NGTGDLLSNS
RYTITTSGGL YIQNVTLDDH GQFVCHASNN QDSIQASANI IVQAPPWLTV TPRDQVVIEG
HTVDFDCAAE GNPPPIIAWT KAGSQLPNDR RHAVLSSGTL RIVHVAQHDQ GQYECQAVSV
IGVRGVPVQL TVQANVLPVF THVPNDITVL VGEDVQIPCS AQGEPQPIIT WSKDGVQITE
SGKFHVNSEG MLTVRDVGQA EQGRYECIAR NALGLSASSM LLTVTVPEGR RAGDNFVEPS
ILDAIQRVDS AINSTRRDLF DKRPRTPSDL LALFRYPRDP FTVEIARAGE IFEQTLQLIQ
EHVRQGLTVD LNGTDFRYND LVSPHYLSLI ANLSGCTAHR RLLNCSNICF HQKYRTHDGT
CNNLQNPMWG ASLIAFQRIL KPVYENGFSL PRGVSQDRLY NGHPLPMPRL ISTTIVGTET
ITPDDRYTHM VMQWGQFLDH DLDQTVPALS MSRFSDGQSC SSACTNDPPC FPIMIPENDP
RVRNARCMFF VRSSPVCGSG MTSLLMSSVY PREQINHLTS YIDASNVYGS SEVESEQLRN
LTNQHGLLKR GILWPLSGKY LLPYATGPPT ECMRDENESS IPCFLAGDHR ANEQLGLTAM
HTLWYREHNR IATELLKLNP HWDGDTIYHE ARKIVGAQMQ HITYQHWLPK ILGDHGMKMM
GEYKGYNPNV NSGIINAFAT AAFRFGHTLI NPILYRLNET FDEIPEGHIP LHKAFFSPFR
IIQEGGIDPL LRGLFGVAGK MRVPSQLLNL ELTEKLFSVA HLVALDLAAI NIQRGRDHGV
PPYVDYRVFC NLSSVQDFEE FKNEIKNPDV RERLKRLYGT PLNIDLWPAL MVEDVIPGTR
VGPTLMCLFV TQFKRLRDGD RFWYENPGVF TPAQLTQLKQ ASLARVLCDS GDNIQQVQPD
VFLKAEYPHG YVNCDQIPKI DLRVWQDCCE DCRTRGQFSA LSQHFRNKRS TEFSYPEKKE
TKDYPNSEKP IGFLEDVDIF NNSAHPSNKT SFDSTREFNN FISEVQKTIS SLKNQINKLE
ARLRHEGCMD KGGIYRRENE HWVKEECDNC HCKNGQVTCY VETCPPVECP NPIKPKGRCC
PICSENESSN ESSVQL
//
