ID M3XHP4_LATCH Unreviewed; 257 AA.
AC M3XHP4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Claudin 34 {ECO:0008006|Google:ProtNLM};
GN Name=CLDN34A {ECO:0000313|Ensembl:ENSLACP00000022250.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022250.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000022250.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}.
CC -!- SIMILARITY: Belongs to the claudin family.
CC {ECO:0000256|ARBA:ARBA00008295}.
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DR EMBL; AFYH01262773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006013853.1; XM_006013791.2.
DR RefSeq; XP_014339574.1; XM_014484088.1.
DR RefSeq; XP_014339575.1; XM_014484089.1.
DR RefSeq; XP_014339576.1; XM_014484090.1.
DR RefSeq; XP_014339577.1; XM_014484091.1.
DR RefSeq; XP_014339578.1; XM_014484092.1.
DR AlphaFoldDB; M3XHP4; -.
DR STRING; 7897.ENSLACP00000022250; -.
DR Ensembl; ENSLACT00000025762.1; ENSLACP00000022250.1; ENSLACG00000022660.1.
DR GeneID; 102356470; -.
DR KEGG; lcm:102356470; -.
DR CTD; 635396; -.
DR eggNOG; ENOG502S127; Eukaryota.
DR GeneTree; ENSGT00390000005717; -.
DR HOGENOM; CLU_084794_0_0_1; -.
DR InParanoid; M3XHP4; -.
DR OMA; HVSSGYK; -.
DR OrthoDB; 4097753at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF4; CLAUDIN-34; 1.
DR Pfam; PF13903; Claudin_2; 1.
DR PRINTS; PR01077; CLAUDIN.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 257 AA; 28681 MW; 8A33E1480DB02226 CRC64;
MAYLASSANL QLTAFFIGSV GWIFSSVITG LLQWRVWYFY NSTVITSEIA WVGIWRACFF
SSVLVSPELK KMYCQRITFS DSFVPTEICV AQCLMLGAIT FGGIGKIAAI LGLREAYFNE
NRYKIHTFFS VGAVLNMSAA LCIIISVAWN WNSVIKNHSI DFPSYFNLPS SPDKQEAGAA
LPIGVLSVFL LVISGSFLLM YHLPQSSELK VYPDHSRPTS GETLSSRTIL PIRSNSAEQV
STLYAVENEN FNWDEHH
//
