ID M3XHS2_LATCH Unreviewed; 279 AA.
AC M3XHS2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Insulin like growth factor binding protein 2 {ECO:0000313|Ensembl:ENSLACP00000022278.1};
GN Name=IGFBP2 {ECO:0000313|Ensembl:ENSLACP00000022278.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022278.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000022278.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR EMBL; AFYH01035969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01035970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01035971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01035972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005991808.1; XM_005991746.2.
DR AlphaFoldDB; M3XHS2; -.
DR STRING; 7897.ENSLACP00000022278; -.
DR MEROPS; I31.953; -.
DR Ensembl; ENSLACT00000025387.1; ENSLACP00000022278.1; ENSLACG00000008519.2.
DR GeneID; 102350074; -.
DR KEGG; lcm:102350074; -.
DR CTD; 794176; -.
DR eggNOG; ENOG502QRWQ; Eukaryota.
DR GeneTree; ENSGT00940000158542; -.
DR InParanoid; M3XHS2; -.
DR OMA; DPECHLY; -.
DR OrthoDB; 5394492at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR CDD; cd00191; TY; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR012210; IGFBP-2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF5; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01978; IGFBPFAMILY2.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..279
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004043637"
FT DOMAIN 22..104
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 186..268
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
SQ SEQUENCE 279 AA; 30863 MW; 84E37B6DB35751CC CRC64;
MLSCLGWLVA LLLFWRPLRG ELLFRCPPCS PERLAVCPAP RALLCSETVR EPGCGCCPVC
AQVEGEPCGV YTARCATGLR CYPNPGSDLP LQTLVQGLGT CLKRRDTDYG SHERDTENGE
DPSEVIIADN RVDSSTPVGD GGRRHPKPGK EIAIYREKIS DQSKHLGKGH KHHSDGVKQM
RLPHLRSLCQ QELDQALGRI SIMNLADDRG PLERLYSLHL PNCDKHGQYN LKQCKMSLNG
QRGECWCVNP NTGKPIPGAP TVRGDPECHL YYTRQGAEE
//
