ID M3XIF3_LATCH Unreviewed; 472 AA.
AC M3XIF3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=RasGEF domain family member 1B {ECO:0000313|Ensembl:ENSLACP00000022509.1};
GN Name=RASGEF1B {ECO:0000313|Ensembl:ENSLACP00000022509.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022509.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000022509.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01094213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005998629.1; XM_005998567.1.
DR AlphaFoldDB; M3XIF3; -.
DR STRING; 7897.ENSLACP00000022509; -.
DR Ensembl; ENSLACT00000025723.1; ENSLACP00000022509.1; ENSLACG00000013705.2.
DR GeneID; 102352044; -.
DR KEGG; lcm:102352044; -.
DR eggNOG; KOG3541; Eukaryota.
DR GeneTree; ENSGT00940000155816; -.
DR InParanoid; M3XIF3; -.
DR OMA; ISQTWEH; -.
DR OrthoDB; 7992at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000013705; Expressed in mesonephros and 5 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF197; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 34..164
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 204..452
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 472 AA; 55348 MW; A366E0F5F487D9B8 CRC64;
MPQTPTFATM FSSNGYNRNQ FHSKEDSCGT LYYHDNNLLS GSLEALIQHL VPNVDYYPDR
TYIFTFLLSS RLFIHPFELM AKVCHLCIEQ QRLNEPLLDK NRIRKIAPKF LQLLTEWTET
FPYDFRDERM MRNLKEMAQR ISQGDEMYRK NVQQIIQNLI RKLATLGQYE EVLAKISATA
TDRLLVLKAK PQSIQRDIVT VCNDPYTLAQ QLTHIELERL SYIGPEEFVQ AFVHKDPLDN
DKSCFGDRKK TRNLEAYVEW FNRLSYLVAT EICMPVKKKH RARVIEYFID VARECFNIGN
FNSLMAIISG MNMSPVSRLK KTWAKVKTAK FDILEHQMDP SSNFYNYRTA LRGAAQRSLT
AHSNREKIVI PFFSLLIKDI YFLNEGCANR LPNGHVNFEK FWELAKQVSE FMAWKQVDCP
FERDRKILQY LLTAPVFSED ALYLASYESE GPENHIEKDR WKTLRSTLLS RV
//
