GenomeNet

Database: UniProt
Entry: M3XII8_LATCH
LinkDB: M3XII8_LATCH
Original site: M3XII8_LATCH 
ID   M3XII8_LATCH            Unreviewed;      3070 AA.
AC   M3XII8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   10-FEB-2021, entry version 47.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000022544};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSLACP00000022544};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022544, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000022544}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000022544};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSLACP00000022544}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
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DR   EMBL; AFYH01094288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01094295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_014345462.1; XM_014489976.1.
DR   STRING; 7897.ENSLACP00000022544; -.
DR   Ensembl; ENSLACT00000025563; ENSLACP00000022544; ENSLACG00000007875.
DR   GeneID; 102353984; -.
DR   KEGG; lcm:102353984; -.
DR   CTD; 1063; -.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   InParanoid; M3XII8; -.
DR   OMA; YNAQLVQ; -.
DR   OrthoDB; 205405at2759; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR   GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 3.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 2.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT   DOMAIN          1..304
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          2017..2157
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2253..2392
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2922..2964
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          205..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1813..1834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2778..2803
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2837..2891
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3012..3070
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          20..82
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          97..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          162..189
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          404..519
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          531..593
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          604..624
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          653..708
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          713..740
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          780..800
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          812..888
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          899..919
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          927..954
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          962..996
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1004..1109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1124..1172
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1184..1246
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1254..1313
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1341..1382
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1390..1410
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1418..1438
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1479..1499
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1595..1664
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1676..1728
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1965..1999
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2014..2062
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2070..2121
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2126..2167
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2264..2368
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2380..2407
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2415..2435
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2450..2470
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2478..2519
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2527..2589
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2594..2667
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2682..2738
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2746..2773
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2817..2837
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        205..238
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..278
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2837..2874
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2875..2891
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3012..3048
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3070 AA;  355088 MW;  85C0A931070117D1 CRC64;
     MSWAIEEWKE GLPSKALQKI QDFESQLEKL KKERQQKQFQ LESLEAAFQK QKQKVENEKS
     EVTALKRENQ SLVESCDNLE KSKQKISHDL QVKELQVNFL EGQLATCKKQ IEKLEQEMKR
     SKCEIERSQQ PLLLGDLQPC ATPEKNFAVP VAPSRNYNDS KVEELQEKYN KEVEERKRLE
     AELKIMQAKV VNQSQGNVNR RDIARQQASS SVFPWQQEQT PSHAASNSLE TPSRRGCTTS
     HFPWEREETP SMYCQRSAKK TASNSSFNES SSNSPQNDLL KVQNQELNSK VTELELRLQA
     QEKEMKTCAN KLQEVQAHFE KAKLELSEKD KALNKYRDEV TKMTTQLDQS SSKCEVVEQK
     LKQVSEELIC QRQNTDSARH TMEQRLKEKE KEYQQELCQQ LHSFQILDQQ FKQMKTELQQ
     AKNDRNTLQA EIDKLSTMKQ RAEKEVEDMK QTLFRTEQTL QAKEKDFKKT VEEVQKEKNN
     LHCQFEQSSR QVHQQEEELK MTQQHLKQSQ SLVEELKSKN IAREVQLLSF KEKLDKQEQS
     LNTDLENLRQ TVADLQKQQD SAQDILTKRE KEMEEMNNKI ITMEKETEEL QNALCLKYNE
     CAELKRETSL LSEWKNKTEN LKNQMLCEKE GMLKEIQELE KCLESHQYDN ERIKVLENEK
     QNLCLQIENY ERLLDCKSAD LESQKQIYEK LRKTAEQADQ KYSKEKENMC LQVIQLTAQA
     NGLEKKLQLE TNKILKMEQS YSELCAEYER ATNLAKSKES VIELKEAEML NLQNSLSETI
     IDFEKQLAKV NSEKSDLIKE HENAVLGKAV EAENMKLELE KCQNDIAFSK EQISSLECDL
     KLQKDLNSEL ESRCEELMKV KDELEEKLVE VAKNLEIVQA EAKEERELKI TVSAQQQRVD
     DLLATVQEKE MSIQKLTSEQ ERKESCLQSL QSSNQLLEVQ VQQLNIQSEA QRQEKEDILA
     SIFSNEKEVE NLAKENEKLK EVIDTLSQEK QVLLEKNSNF ANMVKEKEAE VSELSTRRAE
     EHQTILENNV KLESELANLQ KKYSCMEETK DELEVQIKEK TEKLEEQERK FNKQCAEYLS
     KMEHYEEANQ SLVKEVEKVQ SSLNNKLEET TQFKERLIVS EKETENLRKK LSDTTEGYKE
     LQEMLRRLQQ ENELLNQQVT EERKKLSCLR NAFNENETVF AKKNKDACLK IDQLEKELST
     AQNQQLKSSE LAKEKTQYGE ELREAMREKE SDLSKIQVQL EMLQMDLEDK EVCIESYSTQ
     IEQMEATVKK MESELRESEE QKTIVREEKN SLCKELEATK SKLSDALEKE QILKLCAEHK
     EQSEKELAAV SQEYKSCQLL KTKLETSLQE VSSKCEELEK MYERMQTEKS ELISELSNLR
     TQCTTVLDEN SGLADKIKHL ENEVNLSKDE STALHSKLMS LKDENEKLKE WAKQEECEKL
     KLCNKEIERH LFEVNEKLSC SQKEYDIVQE QYCCAMSKVS ELQSLVETLE EEKSVLVAKL
     EEVYSSKMDA PEFSDRIEPK QTCAIFEHES PIHIKEDNAH ENPVNIKEDP AVSKHHIAAE
     GTDHFNQSAE VDKADELQTQ LNMAERKLFD TEIILSKTNV EKAALEAEVN ILETSLESAQ
     LQLTEQKAQL QHLEQLILER ETEVMDLKEQ LNDFKGNLVS KENNASQTEG NLPKEIEELK
     ILSETYETGI KKLEEQLQMQ KDARNGEIQE LSQTLAATKN ELTCLQKQHS SEIDQWQQKL
     SSMTLEMETK LAAERQQTEI LSTELKGARI QIQHLDLSSH SLLCAETEEV QNGSCIQDQK
     EEINENLQYI NSFSKDPQSE PQSNERDGIE TENTIDISQE NISRLDVETE TDSVADNTVE
     CLRATVEFLC LDSNTSTHQE DFQETHVVPE SCTSQPENVS SKQEFLSQEL EEYKKDDILL
     KEEQHLYSRL DSQQLQSTSQ NSACTELQNV VYKLEEEKSV LSDRIKSTNL ENQKLSERIK
     DLEKELNSMT SEQEVYKARL SDVTEMLHSL EMVKGNWNEK YLEVENELKR TRSEKANLEK
     HILSMEADIE EMQIAKTSLE KEAANSSKCI SRLGEQLSVA TADKNQLSQE LESSREIQEE
     LEQISQNLKE KLEQLASDKV NYTEFIKVLE AENKKLTKQL EITKFDVEKL SKERNSILEQ
     LDCLEKNVLS DEKGELQKQF DQRTEEKEVL LNECETLQGK ICALEMENSR LSQSLESSLV
     EKGEIASRLN STQEEVVQMR HGIEKLKVRI ESDEKKRHHE AEKLKASERK ADSFQDKVEK
     LQRELQMSEE SLEGMVLEAE TVKEEMEKLV TVKQEISKKL QILETEVNTL SSERDLLDKE
     LQQKQLKISE LEGSCMDITN LLKKVEEEKL QVMQEHVVSQ KALKSELMEL NEKLKICSEE
     LENWRAKEQD WLGQISGLEC EKTELSQQLQ QKESSFAELH SANVSLTQDL LASKQELNEQ
     VKANNRLQQE VTDMQQWKQK ISEQLSNVEA EKVSLEKERN QLQTITTESE QRVQALEAKN
     FKMQGTIEGL EGSQQLLEDE LQSAKLQNSA LLEQIQKITE NDSRVRSDLN AANQKIEKMQ
     EECNLERSTL VAQINNAQQQ EESYKVQLDL VTSEKEEMKK RLQHLQNELQ ISEEKIKEER
     MEYQHQLQEA EEKQKTLLKE GREKEAEVHT EREKLITMRQ MLNDHILEIN NLKSAKEQLN
     AALRKAESKL EQLNEKKVED LKTTIVQLKK EKESAVSKLQ LWMRSCKQME QEKEMLLKDI
     EQQDALLNKL KKNEKIETDT NADGVSSELE ELRETVEEKT READESMEKY CNLIINYHKL
     EEANETLKNR IAFLSSQLKQ PGSQDSNSTA KTTPDNPPNS KTGNLKTGKT SPWDRSRPCN
     KRHRTVEPKE DGLELEKVEA TECVSKRIRN GKENGMSRHS AGGDNVEFKP EGLPEVVKKG
     FADIPAGTAS PFILRRTTLQ RRSPRLAAQK TSPITQVVQK VALENQAQNS KTPGGSKLQQ
     VKEVSSFSLG SVLGPVASTS GSPLSSVINS PKKTAFQIPS GSAPTRRSRR SPSTRKYPEQ
     EEEEENCNVQ
//
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