ID M3XII8_LATCH Unreviewed; 3070 AA.
AC M3XII8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 18-JUN-2025, entry version 69.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSLACP00000022544.1};
GN Name=CENPF {ECO:0000313|Ensembl:ENSLACP00000022544.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022544.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000022544.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR EMBL; AFYH01094288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014345462.1; XM_014489976.2.
DR FunCoup; M3XII8; 952.
DR STRING; 7897.ENSLACP00000022544; -.
DR Ensembl; ENSLACT00000025563.1; ENSLACP00000022544.1; ENSLACG00000007875.2.
DR GeneID; 102353984; -.
DR KEGG; lcm:102353984; -.
DR CTD; 1063; -.
DR eggNOG; ENOG502QVMD; Eukaryota.
DR GeneTree; ENSGT00730000111187; -.
DR InParanoid; M3XII8; -.
DR OMA; EQPNEQH; -.
DR OrthoDB; 10255522at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000007875; Expressed in pelvic fin and 1 other cell type or tissue.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0000922; C:spindle pole; IEA:TreeGrafter.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase chromosome alignment; IEA:TreeGrafter.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:TreeGrafter.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:TreeGrafter.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR Gene3D; 1.10.287.1490; -; 2.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874:SF10; CENTROMERE PROTEIN F; 1.
DR PANTHER; PTHR18874; CMF/LEK/CENP CELL DIVISION-RELATED; 1.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
DR SUPFAM; SSF57997; Tropomyosin; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 1..304
FT /note="Centromere protein Cenp-F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 2017..2158
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2253..2392
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2922..2964
FT /note="Kinetochore protein Cenp-F/LEK1 Rb protein-binding"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 205..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1813..1834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2778..2803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2837..2891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3012..3070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 20..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 162..189
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 653..740
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 780..1313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1341..1438
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1595..1728
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1965..2167
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 206..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..274
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1813..1822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2790..2803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2837..2870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3017..3032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3060..3070
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3070 AA; 355088 MW; 85C0A931070117D1 CRC64;
MSWAIEEWKE GLPSKALQKI QDFESQLEKL KKERQQKQFQ LESLEAAFQK QKQKVENEKS
EVTALKRENQ SLVESCDNLE KSKQKISHDL QVKELQVNFL EGQLATCKKQ IEKLEQEMKR
SKCEIERSQQ PLLLGDLQPC ATPEKNFAVP VAPSRNYNDS KVEELQEKYN KEVEERKRLE
AELKIMQAKV VNQSQGNVNR RDIARQQASS SVFPWQQEQT PSHAASNSLE TPSRRGCTTS
HFPWEREETP SMYCQRSAKK TASNSSFNES SSNSPQNDLL KVQNQELNSK VTELELRLQA
QEKEMKTCAN KLQEVQAHFE KAKLELSEKD KALNKYRDEV TKMTTQLDQS SSKCEVVEQK
LKQVSEELIC QRQNTDSARH TMEQRLKEKE KEYQQELCQQ LHSFQILDQQ FKQMKTELQQ
AKNDRNTLQA EIDKLSTMKQ RAEKEVEDMK QTLFRTEQTL QAKEKDFKKT VEEVQKEKNN
LHCQFEQSSR QVHQQEEELK MTQQHLKQSQ SLVEELKSKN IAREVQLLSF KEKLDKQEQS
LNTDLENLRQ TVADLQKQQD SAQDILTKRE KEMEEMNNKI ITMEKETEEL QNALCLKYNE
CAELKRETSL LSEWKNKTEN LKNQMLCEKE GMLKEIQELE KCLESHQYDN ERIKVLENEK
QNLCLQIENY ERLLDCKSAD LESQKQIYEK LRKTAEQADQ KYSKEKENMC LQVIQLTAQA
NGLEKKLQLE TNKILKMEQS YSELCAEYER ATNLAKSKES VIELKEAEML NLQNSLSETI
IDFEKQLAKV NSEKSDLIKE HENAVLGKAV EAENMKLELE KCQNDIAFSK EQISSLECDL
KLQKDLNSEL ESRCEELMKV KDELEEKLVE VAKNLEIVQA EAKEERELKI TVSAQQQRVD
DLLATVQEKE MSIQKLTSEQ ERKESCLQSL QSSNQLLEVQ VQQLNIQSEA QRQEKEDILA
SIFSNEKEVE NLAKENEKLK EVIDTLSQEK QVLLEKNSNF ANMVKEKEAE VSELSTRRAE
EHQTILENNV KLESELANLQ KKYSCMEETK DELEVQIKEK TEKLEEQERK FNKQCAEYLS
KMEHYEEANQ SLVKEVEKVQ SSLNNKLEET TQFKERLIVS EKETENLRKK LSDTTEGYKE
LQEMLRRLQQ ENELLNQQVT EERKKLSCLR NAFNENETVF AKKNKDACLK IDQLEKELST
AQNQQLKSSE LAKEKTQYGE ELREAMREKE SDLSKIQVQL EMLQMDLEDK EVCIESYSTQ
IEQMEATVKK MESELRESEE QKTIVREEKN SLCKELEATK SKLSDALEKE QILKLCAEHK
EQSEKELAAV SQEYKSCQLL KTKLETSLQE VSSKCEELEK MYERMQTEKS ELISELSNLR
TQCTTVLDEN SGLADKIKHL ENEVNLSKDE STALHSKLMS LKDENEKLKE WAKQEECEKL
KLCNKEIERH LFEVNEKLSC SQKEYDIVQE QYCCAMSKVS ELQSLVETLE EEKSVLVAKL
EEVYSSKMDA PEFSDRIEPK QTCAIFEHES PIHIKEDNAH ENPVNIKEDP AVSKHHIAAE
GTDHFNQSAE VDKADELQTQ LNMAERKLFD TEIILSKTNV EKAALEAEVN ILETSLESAQ
LQLTEQKAQL QHLEQLILER ETEVMDLKEQ LNDFKGNLVS KENNASQTEG NLPKEIEELK
ILSETYETGI KKLEEQLQMQ KDARNGEIQE LSQTLAATKN ELTCLQKQHS SEIDQWQQKL
SSMTLEMETK LAAERQQTEI LSTELKGARI QIQHLDLSSH SLLCAETEEV QNGSCIQDQK
EEINENLQYI NSFSKDPQSE PQSNERDGIE TENTIDISQE NISRLDVETE TDSVADNTVE
CLRATVEFLC LDSNTSTHQE DFQETHVVPE SCTSQPENVS SKQEFLSQEL EEYKKDDILL
KEEQHLYSRL DSQQLQSTSQ NSACTELQNV VYKLEEEKSV LSDRIKSTNL ENQKLSERIK
DLEKELNSMT SEQEVYKARL SDVTEMLHSL EMVKGNWNEK YLEVENELKR TRSEKANLEK
HILSMEADIE EMQIAKTSLE KEAANSSKCI SRLGEQLSVA TADKNQLSQE LESSREIQEE
LEQISQNLKE KLEQLASDKV NYTEFIKVLE AENKKLTKQL EITKFDVEKL SKERNSILEQ
LDCLEKNVLS DEKGELQKQF DQRTEEKEVL LNECETLQGK ICALEMENSR LSQSLESSLV
EKGEIASRLN STQEEVVQMR HGIEKLKVRI ESDEKKRHHE AEKLKASERK ADSFQDKVEK
LQRELQMSEE SLEGMVLEAE TVKEEMEKLV TVKQEISKKL QILETEVNTL SSERDLLDKE
LQQKQLKISE LEGSCMDITN LLKKVEEEKL QVMQEHVVSQ KALKSELMEL NEKLKICSEE
LENWRAKEQD WLGQISGLEC EKTELSQQLQ QKESSFAELH SANVSLTQDL LASKQELNEQ
VKANNRLQQE VTDMQQWKQK ISEQLSNVEA EKVSLEKERN QLQTITTESE QRVQALEAKN
FKMQGTIEGL EGSQQLLEDE LQSAKLQNSA LLEQIQKITE NDSRVRSDLN AANQKIEKMQ
EECNLERSTL VAQINNAQQQ EESYKVQLDL VTSEKEEMKK RLQHLQNELQ ISEEKIKEER
MEYQHQLQEA EEKQKTLLKE GREKEAEVHT EREKLITMRQ MLNDHILEIN NLKSAKEQLN
AALRKAESKL EQLNEKKVED LKTTIVQLKK EKESAVSKLQ LWMRSCKQME QEKEMLLKDI
EQQDALLNKL KKNEKIETDT NADGVSSELE ELRETVEEKT READESMEKY CNLIINYHKL
EEANETLKNR IAFLSSQLKQ PGSQDSNSTA KTTPDNPPNS KTGNLKTGKT SPWDRSRPCN
KRHRTVEPKE DGLELEKVEA TECVSKRIRN GKENGMSRHS AGGDNVEFKP EGLPEVVKKG
FADIPAGTAS PFILRRTTLQ RRSPRLAAQK TSPITQVVQK VALENQAQNS KTPGGSKLQQ
VKEVSSFSLG SVLGPVASTS GSPLSSVINS PKKTAFQIPS GSAPTRRSRR SPSTRKYPEQ
EEEEENCNVQ
//
