ID M3XII8_LATCH Unreviewed; 3070 AA.
AC M3XII8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 10-FEB-2021, entry version 47.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000022544};
GN Name=CENPF {ECO:0000313|Ensembl:ENSLACP00000022544};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022544, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Ensembl:ENSLACP00000022544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000022544};
RX PubMed=9215903;
RA Zardoya R., Meyer A.;
RT "The complete DNA sequence of the mitochondrial genome of a 'living
RT fossil,' the coelacanth (Latimeria chalumnae).";
RL Genetics 146:995-1010(1997).
RN [2] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSLACP00000022544}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2013) to UniProtKB.
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DR EMBL; AFYH01094288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014345462.1; XM_014489976.1.
DR STRING; 7897.ENSLACP00000022544; -.
DR Ensembl; ENSLACT00000025563; ENSLACP00000022544; ENSLACG00000007875.
DR GeneID; 102353984; -.
DR KEGG; lcm:102353984; -.
DR CTD; 1063; -.
DR eggNOG; ENOG502QVMD; Eukaryota.
DR GeneTree; ENSGT00730000111187; -.
DR InParanoid; M3XII8; -.
DR OMA; YNAQLVQ; -.
DR OrthoDB; 205405at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 3.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 1..304
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 2017..2157
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2253..2392
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2922..2964
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 205..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1813..1834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2778..2803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2837..2891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3012..3070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 20..82
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 97..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 162..189
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 404..519
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 531..593
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 604..624
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 653..708
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 713..740
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 780..800
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 812..888
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 899..919
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 927..954
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 962..996
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1004..1109
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1124..1172
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1184..1246
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1254..1313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1341..1382
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1390..1410
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1418..1438
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1479..1499
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1595..1664
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1676..1728
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1965..1999
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2014..2062
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2070..2121
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2126..2167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2264..2368
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2380..2407
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2415..2435
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2450..2470
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2478..2519
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2527..2589
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2594..2667
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2682..2738
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2746..2773
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2817..2837
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 205..238
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..278
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2837..2874
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2875..2891
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3012..3048
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3070 AA; 355088 MW; 85C0A931070117D1 CRC64;
MSWAIEEWKE GLPSKALQKI QDFESQLEKL KKERQQKQFQ LESLEAAFQK QKQKVENEKS
EVTALKRENQ SLVESCDNLE KSKQKISHDL QVKELQVNFL EGQLATCKKQ IEKLEQEMKR
SKCEIERSQQ PLLLGDLQPC ATPEKNFAVP VAPSRNYNDS KVEELQEKYN KEVEERKRLE
AELKIMQAKV VNQSQGNVNR RDIARQQASS SVFPWQQEQT PSHAASNSLE TPSRRGCTTS
HFPWEREETP SMYCQRSAKK TASNSSFNES SSNSPQNDLL KVQNQELNSK VTELELRLQA
QEKEMKTCAN KLQEVQAHFE KAKLELSEKD KALNKYRDEV TKMTTQLDQS SSKCEVVEQK
LKQVSEELIC QRQNTDSARH TMEQRLKEKE KEYQQELCQQ LHSFQILDQQ FKQMKTELQQ
AKNDRNTLQA EIDKLSTMKQ RAEKEVEDMK QTLFRTEQTL QAKEKDFKKT VEEVQKEKNN
LHCQFEQSSR QVHQQEEELK MTQQHLKQSQ SLVEELKSKN IAREVQLLSF KEKLDKQEQS
LNTDLENLRQ TVADLQKQQD SAQDILTKRE KEMEEMNNKI ITMEKETEEL QNALCLKYNE
CAELKRETSL LSEWKNKTEN LKNQMLCEKE GMLKEIQELE KCLESHQYDN ERIKVLENEK
QNLCLQIENY ERLLDCKSAD LESQKQIYEK LRKTAEQADQ KYSKEKENMC LQVIQLTAQA
NGLEKKLQLE TNKILKMEQS YSELCAEYER ATNLAKSKES VIELKEAEML NLQNSLSETI
IDFEKQLAKV NSEKSDLIKE HENAVLGKAV EAENMKLELE KCQNDIAFSK EQISSLECDL
KLQKDLNSEL ESRCEELMKV KDELEEKLVE VAKNLEIVQA EAKEERELKI TVSAQQQRVD
DLLATVQEKE MSIQKLTSEQ ERKESCLQSL QSSNQLLEVQ VQQLNIQSEA QRQEKEDILA
SIFSNEKEVE NLAKENEKLK EVIDTLSQEK QVLLEKNSNF ANMVKEKEAE VSELSTRRAE
EHQTILENNV KLESELANLQ KKYSCMEETK DELEVQIKEK TEKLEEQERK FNKQCAEYLS
KMEHYEEANQ SLVKEVEKVQ SSLNNKLEET TQFKERLIVS EKETENLRKK LSDTTEGYKE
LQEMLRRLQQ ENELLNQQVT EERKKLSCLR NAFNENETVF AKKNKDACLK IDQLEKELST
AQNQQLKSSE LAKEKTQYGE ELREAMREKE SDLSKIQVQL EMLQMDLEDK EVCIESYSTQ
IEQMEATVKK MESELRESEE QKTIVREEKN SLCKELEATK SKLSDALEKE QILKLCAEHK
EQSEKELAAV SQEYKSCQLL KTKLETSLQE VSSKCEELEK MYERMQTEKS ELISELSNLR
TQCTTVLDEN SGLADKIKHL ENEVNLSKDE STALHSKLMS LKDENEKLKE WAKQEECEKL
KLCNKEIERH LFEVNEKLSC SQKEYDIVQE QYCCAMSKVS ELQSLVETLE EEKSVLVAKL
EEVYSSKMDA PEFSDRIEPK QTCAIFEHES PIHIKEDNAH ENPVNIKEDP AVSKHHIAAE
GTDHFNQSAE VDKADELQTQ LNMAERKLFD TEIILSKTNV EKAALEAEVN ILETSLESAQ
LQLTEQKAQL QHLEQLILER ETEVMDLKEQ LNDFKGNLVS KENNASQTEG NLPKEIEELK
ILSETYETGI KKLEEQLQMQ KDARNGEIQE LSQTLAATKN ELTCLQKQHS SEIDQWQQKL
SSMTLEMETK LAAERQQTEI LSTELKGARI QIQHLDLSSH SLLCAETEEV QNGSCIQDQK
EEINENLQYI NSFSKDPQSE PQSNERDGIE TENTIDISQE NISRLDVETE TDSVADNTVE
CLRATVEFLC LDSNTSTHQE DFQETHVVPE SCTSQPENVS SKQEFLSQEL EEYKKDDILL
KEEQHLYSRL DSQQLQSTSQ NSACTELQNV VYKLEEEKSV LSDRIKSTNL ENQKLSERIK
DLEKELNSMT SEQEVYKARL SDVTEMLHSL EMVKGNWNEK YLEVENELKR TRSEKANLEK
HILSMEADIE EMQIAKTSLE KEAANSSKCI SRLGEQLSVA TADKNQLSQE LESSREIQEE
LEQISQNLKE KLEQLASDKV NYTEFIKVLE AENKKLTKQL EITKFDVEKL SKERNSILEQ
LDCLEKNVLS DEKGELQKQF DQRTEEKEVL LNECETLQGK ICALEMENSR LSQSLESSLV
EKGEIASRLN STQEEVVQMR HGIEKLKVRI ESDEKKRHHE AEKLKASERK ADSFQDKVEK
LQRELQMSEE SLEGMVLEAE TVKEEMEKLV TVKQEISKKL QILETEVNTL SSERDLLDKE
LQQKQLKISE LEGSCMDITN LLKKVEEEKL QVMQEHVVSQ KALKSELMEL NEKLKICSEE
LENWRAKEQD WLGQISGLEC EKTELSQQLQ QKESSFAELH SANVSLTQDL LASKQELNEQ
VKANNRLQQE VTDMQQWKQK ISEQLSNVEA EKVSLEKERN QLQTITTESE QRVQALEAKN
FKMQGTIEGL EGSQQLLEDE LQSAKLQNSA LLEQIQKITE NDSRVRSDLN AANQKIEKMQ
EECNLERSTL VAQINNAQQQ EESYKVQLDL VTSEKEEMKK RLQHLQNELQ ISEEKIKEER
MEYQHQLQEA EEKQKTLLKE GREKEAEVHT EREKLITMRQ MLNDHILEIN NLKSAKEQLN
AALRKAESKL EQLNEKKVED LKTTIVQLKK EKESAVSKLQ LWMRSCKQME QEKEMLLKDI
EQQDALLNKL KKNEKIETDT NADGVSSELE ELRETVEEKT READESMEKY CNLIINYHKL
EEANETLKNR IAFLSSQLKQ PGSQDSNSTA KTTPDNPPNS KTGNLKTGKT SPWDRSRPCN
KRHRTVEPKE DGLELEKVEA TECVSKRIRN GKENGMSRHS AGGDNVEFKP EGLPEVVKKG
FADIPAGTAS PFILRRTTLQ RRSPRLAAQK TSPITQVVQK VALENQAQNS KTPGGSKLQQ
VKEVSSFSLG SVLGPVASTS GSPLSSVINS PKKTAFQIPS GSAPTRRSRR SPSTRKYPEQ
EEEEENCNVQ
//
