ID M3XL66_LATCH Unreviewed; 1403 AA.
AC M3XL66;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Nuclear receptor coactivator {ECO:0000256|PIRNR:PIRNR038181};
GN Name=NCOA3 {ECO:0000313|Ensembl:ENSLACP00000023472.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000023472.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000023472.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933, ECO:0000256|PIRNR:PIRNR038181}.
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DR EMBL; AFYH01037492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01037493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01037494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01037495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01037496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01037497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01037498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLACT00000025977.1; ENSLACP00000023472.1; ENSLACG00000006885.2.
DR GeneTree; ENSGT00950000183021; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000006885; Expressed in muscle tissue and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18949; bHLH-PAS_NCoA3_SRC3; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF3; NUCLEAR RECEPTOR COACTIVATOR 3; 1.
DR Pfam; PF07469; DUF1518; 1.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 1.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038181};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038181};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR038181};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR038181}.
FT DOMAIN 26..83
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 118..181
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..616
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1287..1312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 153292 MW; 089DA6F1366FBB83 CRC64;
MSGLGENSLD SVTIETRKRK PSCDTQGGSL NCSGEKRRRE QESKYIEELA ELISANLSDI
DNFNVKPDKC AILKETVRQI RQIKEQGKSS FNDDDVQKAD VSSTGQGVID KDSLGPLLLQ
ALDGFLFVVN CDGNIVFVSE NVTQYLQYKQ EELVNTSVYN ILHEEDRDEF LKNLPKTTVN
GVPWSSETRR QKSHTFNCRM LVKTSRDPLE DVGGNPELRH RYEMMQCFAL SQPRAMMEEG
EDLQSCMICV ARRITVVERS FSSSPESFIT RHDLLGNVLN IDNNSLRASM RPGCEDLVRR
CIQRLSYQSE GQQWSNKRHF REAYLQGQAE SPLYRFSLAD GTIVTAQTKS KLYRSPQTNE
AQGFVSTHFL QREQNGYRPS QNPMVYGMRV PTAGGTNSVA AMNMPPGQGI RNYCINDPSA
MGQMAGMRYG GPGVSGGMGP MNHGSGMQAS PYQSNNYGLS MSSPPHGSPG LNSAQQNLMV
SPRSRGSPKM NASQFSPAAG IHSPMGPTSS TGSNTFCNSS LNALQAISEG VGTSLLSTLS
SPGQKMENSP NMNLPQQSKI SSQDCKSPSG LFGEHNHLEN SVCRPNSREL HGDQKDDKET
NVEGTDNQRG ASESKGHKKL LQLLTSPSED RGHSSSSSAL DSNSKEPFTS VTSPSGVSST
SVPGGVTSTS NIHTTSSSLQ EKHKILHKLL QNGNSPAEVA KITAEATGKD TLHESPSTAT
SGEVIVKQEQ MSPKNKECRA LLKYLLDKDA SKDHSLKDIK PKIEGLDNKI GSCCSSTIAA
STHQEKEEMK IKTEPSDELS GDLDNIEAIL GDLASSEFYP ETITGNVNDL ISKQPLFQES
TSFGMRSPQT VQSSKLPFNR AMSLDSQVTN VGSGPPVRSS TPFTAMSKQD MVGNPRMMGS
QETFPGSMDA PNRNMGIPQR PTMASGDWGL QNSNAKSADS AGPGSIIRPD YNQSMPRQMM
SNSMPGIPAR SNSLPSGRPM MVDMAMGGNT YGQQGPPSHS SSWPDRMLHM EQGPRAIQNR
QPFRGSLDDL LCPPSTAEGQ SDERALLDQL DSLLSNTDVT GLEEIDRALG IPDLVSQRQS
LEPHSEPFQG QEPVLLMEQK PPIYSQPYPA QGAALQGSYT AMQGQQTSFT TMVNPMGQQG
NFPMQGMHPR PSLIRPRMTN APKHLRMQLQ QRLQGQQFLN QSRQALGIKL DGPTGGNPGV
RPGMQTPMTP QLQQNFINGQ MMVPRSREMI LNQQLRHQRI MMLMQQQQQQ SQGFSPPPNV
TAPAGMDSPM GGPPMSQAPP QQFPYPPNYG LSQQPDPAFS RAPSPSNPMM PSRMAPSQNP
VMQHPQTTPM YQSPDMKGWP SASMTRTSFP QQQQFASQGN PGTYNTMMHM NGSGGHMGQI
PGQMGMNPVP MPRMPMGPDP KYC
//
