ID M3XLC8_LATCH Unreviewed; 955 AA.
AC M3XLC8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=MutS homolog 4 {ECO:0000313|Ensembl:ENSLACP00000023534.1};
GN Name=MSH4 {ECO:0000313|Ensembl:ENSLACP00000023534.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000023534.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000023534.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01155080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01155081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01155082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01155083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01155084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014349280.1; XM_014493794.1.
DR AlphaFoldDB; M3XLC8; -.
DR STRING; 7897.ENSLACP00000023534; -.
DR Ensembl; ENSLACT00000026191.1; ENSLACP00000023534.1; ENSLACG00000007186.2.
DR GeneID; 102356945; -.
DR KEGG; lcm:102356945; -.
DR CTD; 4438; -.
DR eggNOG; KOG0220; Eukaryota.
DR GeneTree; ENSGT00550000074897; -.
DR InParanoid; M3XLC8; -.
DR OMA; KMTMLYK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03243; ABC_MutS_homologs; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 772..788
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 106239 MW; 51635F498AFE5302 CRC64;
MFTKPGVCGG STAAGETSFS GRCSSSSSEP EPGRRPRYNF GLMETPRSGE GKGDGYSASE
SGGTSSTERL VQNNKLPSGS HTSGFTPGAA NANNTSRDSC FADKSSFAGN NSVLSVLSAP
SSSLCRDRDG ARVGKTPLSA ISHNTRSSCR MRTPQTGHSV TSSSAISAHC VASVIVAVVE
GRGLARGEIG MASINLRSPE LILSQFADNT TYSKVITKLQ ILTPLEIIMP NTACDKGTAT
KLFSLITENF KTVAFTTVQR KYFNETKGLE YTEQLCIPEF NTVLMEVQSK YYCLAAAAAL
LKYVEFIQNS VYAPKSLKVT FQGSEQTAMI DSTSAQNLEL VINNRDPRNS HTLFGVLNYT
KTPGGNRRLR SNILEPLVDA ETINMRLDCV QELLQDEELF FSLQSVISRF LDTDQLLSVL
VQIPKQDTVT AAESKITNLI YLKHTLELVD PLKAALKNCK TSLLKAYCSS LDDNRFNIIL
DKIKTVINDD TRYTKGCLNM RTQKCYAVRP NINEFLDIAR RTYAEIVDDI AGMITQLGEK
YNLPLKTSFS TARGFFIQMN TDGVILPSGQ LPSEFMKVTK MKNAYSFTSV DLIKMNERCQ
ESLREIYHMT YLIVCRLLSE IYEHIHCLYK LSDAVSMLDM LLSFAHACTL SDYVRPEFTD
TLAIKQGRHP ILEKISVEKP VPNNIYISEG SNFVIITGPN MSGKSTFLKQ IALCQIMAQI
GSFIPAEYAS FRIAEQIFTR IGVDDDIETN SSTFMKEMKE ITFIIQNAND RSLIIIDELG
RGTSTEEGVG ICHAICEYLL NLKAFTLFAT HFLELCHLDA LYPNVENNHF EVQHTRKSPQ
TTEKITYTYV LSKGHTEEKN YGLKAAEVSS LLPSIIHDAK EITSQISKQL WQKQMSTPES
LRQRAVYRLA TRLVQTARNS CLDANSLRVY FRGLKKRYES DCLATEEATE MEVEE
//
