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Database: UniProt
Entry: M3XLS0_MUSPF
LinkDB: M3XLS0_MUSPF
Original site: M3XLS0_MUSPF 
ID   M3XLS0_MUSPF            Unreviewed;       147 AA.
AC   M3XLS0;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   05-JUN-2019, entry version 32.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 9 {ECO:0000256|RuleBase:RU364145};
DE   AltName: Full=Mediator complex subunit 9 {ECO:0000256|RuleBase:RU364145};
GN   Name=MED9 {ECO:0000256|RuleBase:RU364145,
GN   ECO:0000313|Ensembl:ENSMPUP00000000020};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000020, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000000020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000000020};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000000020}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator
CC       involved in the regulated transcription of nearly all RNA
CC       polymerase II-dependent genes. Mediator functions as a bridge to
CC       convey information from gene-specific regulatory proteins to the
CC       basal RNA polymerase II transcription machinery. Mediator is
CC       recruited to promoters by direct interactions with regulatory
CC       proteins and serves as a scaffold for the assembly of a functional
CC       preinitiation complex with RNA polymerase II and the general
CC       transcription factors. {ECO:0000256|RuleBase:RU364145}.
CC   -!- SUBUNIT: Component of the Mediator complex, which is composed of
CC       MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13,
CC       MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21,
CC       MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31,
CC       CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8
CC       subunits form a distinct module termed the CDK8 module. Mediator
CC       containing the CDK8 module is less active than Mediator lacking
CC       this module in supporting transcriptional activation. Individual
CC       preparations of the Mediator complex lacking one or more distinct
CC       subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and
CC       TRAP. {ECO:0000256|RuleBase:RU364145}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364145,
CC       ECO:0000256|SAAS:SAAS00869478}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC       {ECO:0000256|RuleBase:RU364145}.
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DR   EMBL; AEYP01089314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01089315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004776554.1; XM_004776497.2.
DR   STRING; 9668.ENSMPUP00000000020; -.
DR   Ensembl; ENSMPUT00000000020; ENSMPUP00000000020; ENSMPUG00000000020.
DR   GeneID; 101686456; -.
DR   CTD; 55090; -.
DR   eggNOG; ENOG410J0JM; Eukaryota.
DR   eggNOG; ENOG4111U35; LUCA.
DR   GeneTree; ENSGT00390000017379; -.
DR   InParanoid; M3XLS0; -.
DR   OMA; NVIKCMD; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:Ensembl.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR011425; Med9.
DR   InterPro; IPR039242; MED9_metazoa.
DR   PANTHER; PTHR20844; PTHR20844; 1.
DR   Pfam; PF07544; Med9; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364145};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Nucleus {ECO:0000256|RuleBase:RU364145,
KW   ECO:0000256|SAAS:SAAS00869474};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transcription {ECO:0000256|RuleBase:RU364145,
KW   ECO:0000256|SAAS:SAAS00869482};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364145,
KW   ECO:0000256|SAAS:SAAS00869473}.
FT   REGION        1     62       Disordered. {ECO:0000256|MobiDB-lite:
FT                                M3XLS0}.
FT   COILED      119    139       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     16     51       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                M3XLS0}.
SQ   SEQUENCE   147 AA;  16293 MW;  356B6C18D9398ECD CRC64;
     MASAGVAAGR QAEDALPPPA EPPLPETKPL PPSQPPPPVA APQPQQSPAP RPQSPAGVKE
     EENYSFLPLV HNIIKCMDKD SPDIHQDLNA LKTKFQEMRK VISAMPGIHL SPEQQQQQLH
     SLREQVRTKN ELLQKYKSLC MFEIPKE
//
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