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Database: UniProt
Entry: M3XRK4_MUSPF
LinkDB: M3XRK4_MUSPF
Original site: M3XRK4_MUSPF 
ID   M3XRK4_MUSPF            Unreviewed;       138 AA.
AC   M3XRK4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Thyrotropin subunit beta {ECO:0000256|ARBA:ARBA00039483};
DE   AltName: Full=Thyroid-stimulating hormone subunit beta {ECO:0000256|ARBA:ARBA00042284};
DE   AltName: Full=Thyrotropin beta chain {ECO:0000256|ARBA:ARBA00042931};
GN   Name=TSHB {ECO:0000313|Ensembl:ENSMPUP00000001704.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000001704.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000001704.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- FUNCTION: Indispensable for the control of thyroid structure and
CC       metabolism. {ECO:0000256|ARBA:ARBA00037283}.
CC   -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC       which confers biological specificity to thyrotropin, lutropin,
CC       follitropin and gonadotropin. {ECO:0000256|ARBA:ARBA00038688}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU004069}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000256|ARBA:ARBA00006552, ECO:0000256|RuleBase:RU004069}.
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DR   EMBL; AEYP01076691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004771155.1; XM_004771098.2.
DR   AlphaFoldDB; M3XRK4; -.
DR   STRING; 9669.ENSMPUP00000001704; -.
DR   Ensembl; ENSMPUT00000001740.1; ENSMPUP00000001704.1; ENSMPUG00000001722.1.
DR   KEGG; mpuf:101694582; -.
DR   eggNOG; ENOG502S2JW; Eukaryota.
DR   GeneTree; ENSGT00940000158152; -.
DR   HOGENOM; CLU_126319_0_2_1; -.
DR   InParanoid; M3XRK4; -.
DR   OMA; PTEYMMH; -.
DR   OrthoDB; 5353873at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR   PANTHER; PTHR11515:SF5; THYROTROPIN SUBUNIT BETA; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hormone {ECO:0000256|RuleBase:RU004069}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..138
FT                   /note="Thyrotropin subunit beta"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004044017"
FT   DOMAIN          20..125
FT                   /note="Glycoprotein hormone subunit beta"
FT                   /evidence="ECO:0000259|Pfam:PF00007"
SQ   SEQUENCE   138 AA;  15666 MW;  23D7490E1056E48E CRC64;
     MTAIYLMSML FGLACGQVMS FCFPTEYTMH VEKKECAYCL TINTTICAGY CMTRDINGKL
     FLPKYALSQD VCTYRDFMYK TVEIPGCPRH VTPYFSYPVA VSCKCGKCNT DYSDCIHEAI
     KTNYCTKPQK SYVVGFSI
//
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