ID M3XRK4_MUSPF Unreviewed; 138 AA.
AC M3XRK4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Thyrotropin subunit beta {ECO:0000256|ARBA:ARBA00039483};
DE AltName: Full=Thyroid-stimulating hormone subunit beta {ECO:0000256|ARBA:ARBA00042284};
DE AltName: Full=Thyrotropin beta chain {ECO:0000256|ARBA:ARBA00042931};
GN Name=TSHB {ECO:0000313|Ensembl:ENSMPUP00000001704.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000001704.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000001704.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: Indispensable for the control of thyroid structure and
CC metabolism. {ECO:0000256|ARBA:ARBA00037283}.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin. {ECO:0000256|ARBA:ARBA00038688}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU004069}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000256|ARBA:ARBA00006552, ECO:0000256|RuleBase:RU004069}.
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DR EMBL; AEYP01076691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004771155.1; XM_004771098.2.
DR AlphaFoldDB; M3XRK4; -.
DR STRING; 9669.ENSMPUP00000001704; -.
DR Ensembl; ENSMPUT00000001740.1; ENSMPUP00000001704.1; ENSMPUG00000001722.1.
DR KEGG; mpuf:101694582; -.
DR eggNOG; ENOG502S2JW; Eukaryota.
DR GeneTree; ENSGT00940000158152; -.
DR HOGENOM; CLU_126319_0_2_1; -.
DR InParanoid; M3XRK4; -.
DR OMA; PTEYMMH; -.
DR OrthoDB; 5353873at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR PANTHER; PTHR11515:SF5; THYROTROPIN SUBUNIT BETA; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hormone {ECO:0000256|RuleBase:RU004069}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..138
FT /note="Thyrotropin subunit beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004044017"
FT DOMAIN 20..125
FT /note="Glycoprotein hormone subunit beta"
FT /evidence="ECO:0000259|Pfam:PF00007"
SQ SEQUENCE 138 AA; 15666 MW; 23D7490E1056E48E CRC64;
MTAIYLMSML FGLACGQVMS FCFPTEYTMH VEKKECAYCL TINTTICAGY CMTRDINGKL
FLPKYALSQD VCTYRDFMYK TVEIPGCPRH VTPYFSYPVA VSCKCGKCNT DYSDCIHEAI
KTNYCTKPQK SYVVGFSI
//