GenomeNet

Database: UniProt
Entry: M3XRU7_MUSPF
LinkDB: M3XRU7_MUSPF
Original site: M3XRU7_MUSPF 
ID   M3XRU7_MUSPF            Unreviewed;      1107 AA.
AC   M3XRU7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   05-JUN-2019, entry version 40.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   Name=POLD1 {ECO:0000313|Ensembl:ENSMPUP00000001797};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000001797, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000001797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000001797};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000001797}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01068196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004767275.2; XM_004767218.2.
DR   STRING; 9668.ENSMPUP00000001797; -.
DR   Ensembl; ENSMPUT00000001833; ENSMPUP00000001797; ENSMPUG00000001815.
DR   GeneID; 101675970; -.
DR   CTD; 5424; -.
DR   eggNOG; KOG0968; Eukaryota.
DR   eggNOG; COG0417; LUCA.
DR   GeneTree; ENSGT00560000077365; -.
DR   InParanoid; M3XRU7; -.
DR   OMA; CLVNYTE; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0016235; C:aggresome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:Ensembl.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006287; P:base-excision repair, gap-filling; IEA:Ensembl.
DR   GO; GO:0045004; P:DNA replication proofreading; IEA:Ensembl.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      131    477       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      542    973       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1012   1082       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     32       Disordered. {ECO:0000256|MobiDB-lite:
FT                                M3XRU7}.
FT   COILED       34     56       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1107 AA;  123814 MW;  3901DAA04735F997 CRC64;
     MDGKRRPGPG PGVPPKRARG GLWDEEEPCQ PSQFEEELAL MEEMEAEHRL QEQEEELVQP
     GLDGAADGQF SPMAIDARWL RPTPPPLDPQ TEPLIFQQLE IDHYVGPAQP LPWTPQPSRN
     PVPVLRAFGV TDEGVSVCCH IQGFAPYFYT PAPPGFGPDH LGELQRELNA AISRDQRGGK
     ELMGPAVLSV ELCSRESMFG YHGHGPSPFL RITLALPRLM APARRLLEQG IRVAGLGTPS
     FAPYEANVDF EIRFMVDTDI VGCNWLELPA GKYVLRSEAK ATLCQLEADV LWSDVVSHPP
     EGQWQRIAPL RVLSFDIECA GRKGIFPEPE RDPVIQICSL GLRWGEPEPF LRLALTLRPC
     APILGAKVQS YEREEELLQA WSAFIRAMDP DVITGYNIQN FDLPYLISRA QTLKVHTFPF
     LGRVSGLRSN IRDSSFQSKQ TGRRDSKVVS MVGRVQMDML QVLLREHKLR SYTLNAVSFH
     FLGEQKEDVQ HSIITDLQNG NDQTRRRLAV YCLKDAFLPL RLLERLMVLV NAMEMARVTG
     VPLGYLLSRG QQVKVVSQLL RQAMREGLLM PVVKTEGGED YTGATVIEPL KGYYDVPIAT
     LDFSSLYPSI MMAHNLCYTT LLRPGAAQRL GLTEDQFIKT PTGDEFVKTS VRKGLLPQIL
     ENLLSARKRA KAELAKETDP LRRQVLDGRQ LALKVSANSV YGFTGAQVGK LPCLEISQSV
     TGFGRQMIEK TKQLVESKYT VENGYGANAK VVYGDTDSVM CRFGVSSVAE AMALGREAAD
     WVSGHFPPPI RLEFEKVYFP YLLISKKRYA GLLFSSRPDT HDRMDCKGLE AVRRDNCPLV
     ANLVTASLRR LLIDRDPAGA VAHAQDVISD LLCNRIDISQ LVITKELTRA AADYAGKQAH
     VELAERMRKR DPGSAPSLGD RVPYVIIGAT KGVAAYMKSE DPLFVLEHSL PIDTQYYLEQ
     QLAKPLLRIF EPILGEGRAE AVLLRGDHTR CKTVLTGKVG GLLAFAKRHS CCIGCRTVLN
     HQGAVCKFCQ PRESELYQKE VSHLNALEER FSRLWTQCQR CQGSLHEDVI CTSRDCPIFY
     MRKKVRKDLE DQEQLLRRFG PPGPEAW
//
DBGET integrated database retrieval system