ID M3XSK9_MUSPF Unreviewed; 1019 AA.
AC M3XSK9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Diaphanous related formin 2 {ECO:0000313|Ensembl:ENSMPUP00000002059.1};
GN Name=DIAPH2 {ECO:0000313|Ensembl:ENSMPUP00000002059.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002059.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000002059.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR EMBL; AEYP01088041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01088042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01088043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01088044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01088045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01088046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01088047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01088048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01088049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01088050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XSK9; -.
DR STRING; 9669.ENSMPUP00000002059; -.
DR Ensembl; ENSMPUT00000002102.1; ENSMPUP00000002059.1; ENSMPUG00000002080.1.
DR eggNOG; KOG1924; Eukaryota.
DR GeneTree; ENSGT00940000157822; -.
DR HOGENOM; CLU_002356_0_0_1; -.
DR InParanoid; M3XSK9; -.
DR OMA; FHHCIES; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF3; PROTEIN DIAPHANOUS HOMOLOG 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 951..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 996..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..460
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 627..1019
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 377..404
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 507..534
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 29..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..591
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 115488 MW; 4D9D7B474057DEB0 CRC64;
MEQPGAAATG AGGGSEEPGG GRSNKRSAGN RAANEEETKN KPKLRDRITS FRKSTVKKEK
PLIQHPIDSQ VTMSEFPAAQ PLYDERSLNL SEKEVLDLFE KMMEDMNLNE DRKAPLRNKD
FTTKREMVVQ YISATAKSIV GSKVMGGLKN SKHECTLSSQ EYVHELRSGI SDEKLLNCLE
SLRVSLTSNP VSWVNNFGHE GLGLLLDVLE KLLDKKQQEN IDKKNQYKLI QCLKAFMNNK
FGLQRILGDE RSLLLLARAI DPKQPNMMTE IVKILSAICI VGEENILDKL LGAITTAAER
NNRERFSPIV EGLENHEALQ LQVACMQFIN ALVTSPYELD FRIHLRNEFL RSGLKTMLPD
LKEKENDELD IQLKVFDENK EDDLNELSHR LNDIRAEMDD MNEVYHLLYN MLKDTAAENY
LLSILQHFLL IRNDYYIRPQ YYKIIEECVS QIVLHCSGMD PDFKYRQRLD VDFTHLIDSC
VNKAKVEESE QKAVEFSKKF DEEFTARQEA QAELQRREEK IKELETEIQQ LRTQGYGLSG
SSGIPGPPPP PLLPGGGSSP PPPPPPPPPA PPLPGGALPP PPPPLPGMIG IPPPPPLFGG
PPPPFPLGGG ILPFPEVPLD LPYGMKQKKL YKPEVPMKRI NWSKIEPKEL SENCFWLKVK
EDKFENPDLF AKLALNFATQ MKVQKNVEAS EEKKILPAKK KVKELRILDP KTAQNLSIFL
GSYRMPYEDI KNIILEVNED MLNEALIQNL VKHLPEQKVL SELAQLRNEY HDLCEPEQFG
VVMSSVKMLQ PRLENILFKL TFEEHVNNIK PSIIAVTLAC EELKKSESFN RLLELVLLVG
NYMNSGSRNA QSLGFKINFL CKIRDTKSAD QKTTLLHFIA EICEEKYRDI LKFPDELEHV
ESASKVSAQI LKSNLTAMEQ QIINLERDIK KFPETEDQHD KFVEKMTISF IYSSILFISF
SLNLFLSLSL SASVCVCVCV CVCVRLHARA CKCTHAYAQG ICIYCVVLNL PVYLFRLSA
//
