ID M3XTI4_MUSPF Unreviewed; 462 AA.
AC M3XTI4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=5-hydroxytryptamine receptor 3E {ECO:0000313|Ensembl:ENSMPUP00000002384.1};
GN Name=HTR3E {ECO:0000313|Ensembl:ENSMPUP00000002384.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002384.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000002384.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; AEYP01017092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XTI4; -.
DR STRING; 9669.ENSMPUP00000002384; -.
DR Ensembl; ENSMPUT00000002433.1; ENSMPUP00000002384.1; ENSMPUG00000002410.1.
DR eggNOG; KOG3645; Eukaryota.
DR GeneTree; ENSGT00940000163899; -.
DR HOGENOM; CLU_018074_5_2_1; -.
DR InParanoid; M3XTI4; -.
DR OMA; SHILCPL; -.
DR GO; GO:1904602; C:serotonin-activated cation-selective channel complex; IEA:Ensembl.
DR GO; GO:0022850; F:serotonin-gated monoatomic cation channel activity; IEA:Ensembl.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:Ensembl.
DR CDD; cd19063; LGIC_TM_5-HT3; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF764; 5-HYDROXYTRYPTAMINE RECEPTOR 3E; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT TRANSMEM 246..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 276..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 305..329
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 440..461
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 39..244
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 252..357
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 462 AA; 52803 MW; ABB4DE77A4C0B8AB CRC64;
LGGPHPASGP LLELSLPQSL FHQWGCMLQQ RNMRFLSLSS HILCPLQKAF RPVTNFSIPT
LVNISFTMSA ILDADEKLQL LSSFLWLDAQ VWDNPFIRWN PEECEGITKI SVTTRNLWLP
DIFIVEFMDV DKTPKGLTAY VSNEGRIRYK KPMKVASICN LDIFYFPFDQ QNCTLTFSSF
LYTVENMLLG MEKEVWEIAD TSQDIVQTHG EWELLGINKS TPKMSLGTSL YDQIMFYVAI
RRRPRLYIIN LLLPSGFLIA IDAISFYLPA ESGNRAPFKI TLLLGYNVFL LMMNDLLPTS
GTPLISVYFA LCLSLMVVSL LETSFITYLP HLATTQPPPM PWWLHSLLLC CTRPRKCCPT
ALQKRNKVPT CLVRGQHCTH YLFPHSFFSA PTSFPVPLPP QPREAELNGW PQSTRAQEED
ETKKQHLVNL WVQFSHRLDT LPFCLYLLLM ATSVVTAIVL WN
//
