ID M3XUA1_MUSPF Unreviewed; 752 AA.
AC M3XUA1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002651.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000002651.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AEYP01080022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01080023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01080024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01080025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01080026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01080027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01080028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01080029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01080030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01080031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XUA1; -.
DR STRING; 9669.ENSMPUP00000002651; -.
DR Ensembl; ENSMPUT00000002706.1; ENSMPUP00000002651.1; ENSMPUG00000002679.1.
DR eggNOG; KOG0196; Eukaryota.
DR GeneTree; ENSGT00940000154490; -.
DR HOGENOM; CLU_000288_141_4_1; -.
DR InParanoid; M3XUA1; -.
DR OMA; YKNNFVA; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 2.
DR CDD; cd05066; PTKc_EphR_A; 1.
DR CDD; cd09547; SAM_EPH-A6; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR042746; EPH-A6_SAM.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF10; EPHRIN TYPE-A RECEPTOR 6; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 239..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..116
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 117..228
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 323..636
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 681..741
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT BINDING 355
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 752 AA; 84189 MW; 8167D0A0EAD70C99 CRC64;
MACTRPPSAP RNVAFNINET ALILEWSPPS DTGGRKDLTY SVICKKCGLD TSQCEDCGGG
LRFIPRHSGL INNSVIVLDF VSHVNYTFEI EAMNGVSELS FSPKPFTAIT VTTDQDAPSL
IGVVRKDWAS QNSIALSWQA PAFSNGAILD YEIKYYEKVY PRIAPAFWHY LRVEEHEQLT
YSSTRSKAPS VIITGLKPAT KYIFHIRVRT ATGYSGYSQK FEFETGDETS DMAAEQGQIL
VIATAAVGGF TLLVILTLFF LITGRCQWYI KAKMKSEEKR RNHLQQNGHL RFPGIKTYID
PDTYEDPSLA VHEFAKEIDP SRIRIERVIG AGEFGEVCSG RLKTPGKREI PVAIKTLKGG
HMDRQRRDFL REASIMGQFD HPNIIRLEGV VTKRSFPAIG VETFCPSFLR AGFLNSIQAP
HPVPGGGSLP PRIPAGRPVM IVVEYMENGS LDSFLRKHDG HFTVIQLVGM LRGIASGMKY
LSDMGYVHRD LAARNILVNS NLVCKVSDFG LSRVLEDDPE AAYTTTGGKI PIRWTAPEAI
AYRKFSSASD AWSYGIVMWE VMSYGERPYW EMSNQDVILS IEEGYRLPAP MGCPASLHQL
MLHCWQKERN HRPKFTDIVS FLDKLIRNPS ALHTLVEDIL VVNGPHSQCP STELSNCSMA
VEAGRMPESP GEVPEYPLFV TVGEWLDSIK MGQYKNNFMA AGFTTFDLIS RMSIDDIRRI
GVLLIGHQRR IVSSIQTLRL QMMHIQEKGF HV
//
