ID M3XUR7_MUSPF Unreviewed; 903 AA.
AC M3XUR7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Chloride channel protein 2 {ECO:0000256|ARBA:ARBA00017377};
GN Name=CLCN2 {ECO:0000313|Ensembl:ENSMPUP00000002817.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002817.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000002817.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClC-
CC 2/CLCN2 subfamily. {ECO:0000256|ARBA:ARBA00005423}.
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DR EMBL; AEYP01017106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004745210.1; XM_004745153.1.
DR AlphaFoldDB; M3XUR7; -.
DR STRING; 9669.ENSMPUP00000002817; -.
DR Ensembl; ENSMPUT00000002876.1; ENSMPUP00000002817.1; ENSMPUG00000002846.1.
DR GeneID; 101681390; -.
DR KEGG; mpuf:101681390; -.
DR CTD; 1181; -.
DR eggNOG; KOG0476; Eukaryota.
DR GeneTree; ENSGT00940000155439; -.
DR HOGENOM; CLU_006904_0_1_1; -.
DR InParanoid; M3XUR7; -.
DR OMA; ACFMFNN; -.
DR OrthoDB; 1194at2759; -.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:Ensembl.
DR GO; GO:0090425; P:acinar cell differentiation; IEA:Ensembl.
DR GO; GO:0060689; P:cell differentiation involved in salivary gland development; IEA:Ensembl.
DR GO; GO:0032347; P:regulation of aldosterone biosynthetic process; IEA:Ensembl.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002244; Cl-channel-2.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR45720:SF6; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01113; CLCHANNEL2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 94..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 649..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 98896 MW; C5F5412419F3FE83 CRC64;
MAAAGAAAAA EGMEPRALQY EQTLMYGRYT QDLGAFAKEE AARIRLGGPE TWRGPPSSRA
PPELLEYGQS RCARCRICSV RCHKFLVSRV GEDWIFLVLL GLLMALVSWA MDYAIAACLQ
AQQWMSRGLN TSLFLQYLAW VTYPIVLITF SAGFTQILAP QAVGSGIPEM KTILRGVVLK
EYLTLKTFVA KVIGLTCALG SGMPLGKEGP FVHIASMCAA LLSKFLSLFG GIYENESRNT
EMLAAACAVG VGCCFAAPIG GVLFSIEVTS TFFAVRNYWR GFFAATFSAF IFRVLAVWNR
DEETITALFK TRFRLDFPFD LQELPAFAVI GIASGFGGAL FVYLNRKIVQ VMRKQKTINR
FLMKKRLLFP ALVTLLISTL TFPPGFGQFM AGQLSQKETL VTLFDNRTWV RQGLVEDLEP
PGTSQAWSPP RANVFLTLVV FILMKFWMSA LATTIPVPCG AFMPVFVIGA AFGRLVGESM
AAWFPDGIHT DGSTYRIVPG GYAVVGAAAL AGAVTHTVST AVIVFELTGQ IAHILPVMIA
VILANAVAQS LQPSLYDSII RIKKLPYLPE LGWGRHQQYR MRVEDIMVRD VPYVALSCTF
RDLRLALHRT KGRMLALVES PESMILLGSI ERSQVVALLA AQLSPARRRQ YAQERRAAQT
SPPPDQESPP SPEASVRFQV NTEDSGFPAA RGDTHKPLKP ALKRGPSNTV NLGESPTGNM
EQAGITLRSL FCGSPPPEAA SELEKSESGD KRKLKRVRIS LASDSDLEGE MSPEEILEWE
EQQLDEPVNF SDCKIDPAPF QLVERTSLHK THTIFSLLGV DHAYVTSIGR LIGIVTLKEL
RKAIEGSVTA QGVKVRPPLA SFRDSATSSS DTETTEVHAL WGPHSHHGLP REGSPSDSDD
KCQ
//
