ID M3XVA0_MUSPF Unreviewed; 3110 AA.
AC M3XVA0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 12-AUG-2020, entry version 40.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSMPUP00000003000};
GN Name=CENPF {ECO:0000313|Ensembl:ENSMPUP00000003000};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000003000, ECO:0000313|Proteomes:UP000000715};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000003000, ECO:0000313|Proteomes:UP000000715}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000003000,
RC ECO:0000313|Proteomes:UP000000715};
RA Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., Przyblyski D.,
RA Ribeiro F., Russell P., Sharpe T., Turner-Maier J., Walker B.J., Young S.,
RA Birren B., Lindblad-Toh K.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMPUP00000003000}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2013) to UniProtKB.
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DR EMBL; AEYP01100372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01100373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9668.ENSMPUP00000003000; -.
DR Ensembl; ENSMPUT00000003061; ENSMPUP00000003000; ENSMPUG00000003030.
DR eggNOG; ENOG502QVMD; Eukaryota.
DR GeneTree; ENSGT00730000111187; -.
DR HOGENOM; CLU_000551_0_0_1; -.
DR InParanoid; M3XVA0; -.
DR OMA; YNAQLVQ; -.
DR Proteomes; UP000000715; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 1..307
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1890..2032
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2128..2267
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2310..2448
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2966..3009
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 245..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1665..1685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1717..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2899..3110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 280..342
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 350..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 386..459
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 467..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 623..643
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 651..713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 725..773
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 838..865
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 902..956
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 968..991
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1028..1083
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1117..1151
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1291..1318
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1330..1357
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1395..1422
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1547..1599
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1787..1814
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1822..1856
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1887..1907
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1936..1994
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1999..2082
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2104..2124
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2139..2201
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2209..2275
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2293..2313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2321..2348
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2356..2600
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2615..2713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2715..2735
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2750..2822
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2830..2860
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2868..2888
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 246..269
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..532
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1669..1685
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2899..2928
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2951..2980
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2995..3009
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3020..3074
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3110 AA; 356849 MW; 3DE2C24E68501B58 CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
CKSELERSQQ AAQAADVSLH PSTTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKTSQAVPQS TMNHRDIARH QASSSVFSWQ QEKTPTRLSS NALKTPIRRE
FSASHFSGEQ EVTPSRSTLQ TGKRDANGSF CDNSSNSHLL DQLKAQNQDL RNKISELELH
LQGQEKEMKG QANKCQELQL QLEKAKAELV EKEKILNKNR DELVRSTAQY DQASTKCTSL
EQKLKRLSED LSCQRQNAES ARCSLEQKLK EKEKEFQEEL SRQQRAFQAL DQECAQTKAR
LTQELQQAKN TGNILQADLD KVTSGKHQLE KTLEEFKQKF CRTEQALQAS QVQENELRRS
SEEVKKEYSV LKSQFEQRAR EVCHLEEELR KARQSLSQSQ NSTEEMRVSN SSRETMLRDL
QEKINQQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLNEKLSK IEKESEALLL
ALELKKKEYE ELKEEKTLFA RWKSENEQLL SQLESEKGSL QSKINHLETC LKTQQIKSHE
YNEKVRTLEM ESENLSVEIR NLHNVIDSKT LEVERQKQAY ADLQQKAEFS DQKHNKEIEN
MCLKISELTG QVHDLEHKLQ LLSSEVIDKD QRYQDLQAEY ENLQDLVKSK DSSLVTNEAL
NRSLLAFEQQ PAMNNSFAIT GEQGSMPSER SKCHLEADPS PKSSAVLQNR VMSLEFSLES
QKQMNSDLQK QCEELVQIRG EIEENLIKAE QMHQSFVAET SQRISKLQED TSVHQNAFTE
TLAALENKER EFQLLNEKLE TEQAEIQELK KSNHLLQDSL KELQLLSETL SSEKKEMSST
ISLNRKEIED LAQENATLKE INATLNQEKI NLLQKSESFA NCIDERDKSI SELSNQYKQE
RLILQQRCEE TGHALEDLSE KYNAAQEKNS QLECLLNECT IACENRQKEL EHLKETFARE
QQAFVTKLAL AEETNQNLVL ELGAVRHDLS SEIADIQNNS KSEADGLKQE IMTLKEEQSK
MQKELNALLQ ENEHLVTLMK TKQEHQIPES EPVSAAVEGV SEINKCHVQL PMDQEVKDPS
LDCQNAQLVQ LEAKGIRELK LREGEKEKEC LLHELCTIRM ELETGNLQPD AQSPEPSGPK
DCDVGTEEKY MSVLHELSAS QNDNAHLLCS LQTAMSKLSE LEKMCEMLRV EKLELMSELD
DSRSECITAT HKMAEEMEKL VNEVKILNNE NGLLQGELVK EMAEDESYEQ QSERKRASLN
PLGDSNCYEH LTLSNKEVQM HFAELQEKFS SLQNEHKILH DQHCQVSSKM SELQSYVDTL
KAENSILSTS LRSFQGDLVK EEMPGPEEGH FLSLSFSCVT DSPSLTRLGE SSFCKDILDQ
TGETSLLNNL DGTISANQSN VEERSCCSPG EENLTKKEIL SAPARSVEEL ETLCQMYVQS
LKELEEKIES QEIMKNKEIK ELEQILSSER EELDYLRKQY LSENEQWQQK LTSVTMEMES
KLAAEKKQTE HLSFELEIAR LQLQGLDLSS RSLLGTDIED ALRGGNSSCD VKESEEYTLE
TQERTPKRDI HQICEEGVQQ DLSREMEKIT KTSPVRFTGE EWSREQSPET PAEDKTQGCL
ECISQLSLSG PNAPVPVDFL ENQVTIQNLQ LQVKESSNEN LRLLHVIEER DKKVESLLNE
IKELDSKLDF QEAQITTKTE ACVELEKIVG KLKKEKSDLR ERLESFACDN QELHQRTESL
EGLNSNLETG TDKRSHAVIE DNVADVNDNW RERFLDAEKE LKRIQFEKGN MEHHALSVEA
NLETVQTEKL YLEKDNESKQ KVITRLEEEL SVVTNERNQL HGELDTLSKE NKELDLMSEK
MKEKICELES HQDECLHHID VAEAELRDKA QLIQTLSSNV TELSEENTRL QEQLQSLEKD
SQALTLVKSE LEIQIEQLNK EKESLAGESE SLQTRLHESE HEKLTIAKAL EDALMEKGEV
AVRLSSTQEE VHQLRKGIEK LRVRIEADDK KQLHVLEKLR ASERKSDSLQ DKVENLEREL
QMSEENQELV ILDAENSKAE VEALKTQMEL MTKTLKDLEL DLGTVKFEKE NLIKQLQEKQ
GQVSELDTLL SSLKSRLEEE EKEKIETREE SKAALEMLQT QLKELNEEVI ALCHDQEIQK
VEEQSMDTSG QKIHQLRNSI EKLKVRLEAD EKEQLQVLGK LKESEHHADL LKDRVEKLER
ELEISGKNQE RMILEAENSK AEVGTLKAKI EEMAQNLRDL ELDLVHVRSE KENVIEELQK
EQGRVSELEI LKSSFENLLQ EKEQEKVQMR EDSKIAVEML QTQVKELNQK VEALGHDQDA
WKAQAQNLHS QVDALELEKA QLLQDLDEVK NNYLNVQSSA NGLLQQVEDG KHKLEKKEEE
ISLLKNQIQD REQLTSKLAQ VEGEQQLWKK QKGELENLLV ELEQKSQGLQ AKNDTLQDTL
EALQRSHKDL EKELELTKIE NMSFVEKVKA MTGKETELQR EMHEMVQKTT ELKEEFTRER
NRLTEELNIM SEDIKSSKGQ LKELMLENSE LKKSLDCIHK DQMEKEEKVR EEIAEYQLQL
QEAEKKHQTL LLDINKQYEM EIQTYREKLS SQEECLSLQK AEVDLLKSSK EELNNSLKAT
TKILEELKKT QADNVKYANQ LKKENERAQG KIKLLIKSCK QLEEEKEMLQ KELSKLEAAQ
EKQKTGTAVD SNAEELMAEI KELKETLEEK NKEADEYLDK YCSLLISHEK LEKAKEMLET
QVARLSSRSK LNLQNSPLLN SVVSEDSPAP SATEKKLSSS QNKTSGKRQR STGIREDGGG
TAPSTPETFS KKSRKAVKSG IHPTEDTRDT EFEPEGLPEV VKKGFADIPT GKTSPYVLRR
TTMPTRTSPR LAAQKLVPSP LSLNKENQAE TSQPTAGGSR SQKVKVAQQS PVDSSASFRE
PTTRSLSVSN LPERSPADSP REGLRAKRGR LAPSPEAVPE SKSSENCRVQ
//
