GenomeNet

Database: UniProt
Entry: M3XVA0_MUSPF
LinkDB: M3XVA0_MUSPF
Original site: M3XVA0_MUSPF 
ID   M3XVA0_MUSPF            Unreviewed;      3110 AA.
AC   M3XVA0;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   12-AUG-2020, entry version 40.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSMPUP00000003000};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSMPUP00000003000};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000003000, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000003000, ECO:0000313|Proteomes:UP000000715}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000003000,
RC   ECO:0000313|Proteomes:UP000000715};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., Przyblyski D.,
RA   Ribeiro F., Russell P., Sharpe T., Turner-Maier J., Walker B.J., Young S.,
RA   Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000003000}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
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DR   EMBL; AEYP01100372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01100373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9668.ENSMPUP00000003000; -.
DR   Ensembl; ENSMPUT00000003061; ENSMPUP00000003000; ENSMPUG00000003030.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; M3XVA0; -.
DR   OMA; YNAQLVQ; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT   DOMAIN          1..307
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1890..2032
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2128..2267
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2310..2448
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2966..3009
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          245..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          803..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1245..1264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1665..1685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1717..1736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2899..3110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          280..342
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          350..377
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          386..459
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          467..487
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          623..643
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          651..713
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          725..773
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          838..865
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          902..956
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          968..991
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1028..1083
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1117..1151
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1291..1318
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1330..1357
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1395..1422
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1547..1599
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1787..1814
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1822..1856
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1887..1907
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1936..1994
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1999..2082
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2104..2124
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2139..2201
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2209..2275
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2293..2313
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2321..2348
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2356..2600
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2615..2713
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2715..2735
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2750..2822
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2830..2860
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2868..2888
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        246..269
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..532
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1669..1685
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2899..2928
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2951..2980
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2995..3009
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3020..3074
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3110 AA;  356849 MW;  3DE2C24E68501B58 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
     EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ AAQAADVSLH PSTTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKTSQAVPQS TMNHRDIARH QASSSVFSWQ QEKTPTRLSS NALKTPIRRE
     FSASHFSGEQ EVTPSRSTLQ TGKRDANGSF CDNSSNSHLL DQLKAQNQDL RNKISELELH
     LQGQEKEMKG QANKCQELQL QLEKAKAELV EKEKILNKNR DELVRSTAQY DQASTKCTSL
     EQKLKRLSED LSCQRQNAES ARCSLEQKLK EKEKEFQEEL SRQQRAFQAL DQECAQTKAR
     LTQELQQAKN TGNILQADLD KVTSGKHQLE KTLEEFKQKF CRTEQALQAS QVQENELRRS
     SEEVKKEYSV LKSQFEQRAR EVCHLEEELR KARQSLSQSQ NSTEEMRVSN SSRETMLRDL
     QEKINQQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLNEKLSK IEKESEALLL
     ALELKKKEYE ELKEEKTLFA RWKSENEQLL SQLESEKGSL QSKINHLETC LKTQQIKSHE
     YNEKVRTLEM ESENLSVEIR NLHNVIDSKT LEVERQKQAY ADLQQKAEFS DQKHNKEIEN
     MCLKISELTG QVHDLEHKLQ LLSSEVIDKD QRYQDLQAEY ENLQDLVKSK DSSLVTNEAL
     NRSLLAFEQQ PAMNNSFAIT GEQGSMPSER SKCHLEADPS PKSSAVLQNR VMSLEFSLES
     QKQMNSDLQK QCEELVQIRG EIEENLIKAE QMHQSFVAET SQRISKLQED TSVHQNAFTE
     TLAALENKER EFQLLNEKLE TEQAEIQELK KSNHLLQDSL KELQLLSETL SSEKKEMSST
     ISLNRKEIED LAQENATLKE INATLNQEKI NLLQKSESFA NCIDERDKSI SELSNQYKQE
     RLILQQRCEE TGHALEDLSE KYNAAQEKNS QLECLLNECT IACENRQKEL EHLKETFARE
     QQAFVTKLAL AEETNQNLVL ELGAVRHDLS SEIADIQNNS KSEADGLKQE IMTLKEEQSK
     MQKELNALLQ ENEHLVTLMK TKQEHQIPES EPVSAAVEGV SEINKCHVQL PMDQEVKDPS
     LDCQNAQLVQ LEAKGIRELK LREGEKEKEC LLHELCTIRM ELETGNLQPD AQSPEPSGPK
     DCDVGTEEKY MSVLHELSAS QNDNAHLLCS LQTAMSKLSE LEKMCEMLRV EKLELMSELD
     DSRSECITAT HKMAEEMEKL VNEVKILNNE NGLLQGELVK EMAEDESYEQ QSERKRASLN
     PLGDSNCYEH LTLSNKEVQM HFAELQEKFS SLQNEHKILH DQHCQVSSKM SELQSYVDTL
     KAENSILSTS LRSFQGDLVK EEMPGPEEGH FLSLSFSCVT DSPSLTRLGE SSFCKDILDQ
     TGETSLLNNL DGTISANQSN VEERSCCSPG EENLTKKEIL SAPARSVEEL ETLCQMYVQS
     LKELEEKIES QEIMKNKEIK ELEQILSSER EELDYLRKQY LSENEQWQQK LTSVTMEMES
     KLAAEKKQTE HLSFELEIAR LQLQGLDLSS RSLLGTDIED ALRGGNSSCD VKESEEYTLE
     TQERTPKRDI HQICEEGVQQ DLSREMEKIT KTSPVRFTGE EWSREQSPET PAEDKTQGCL
     ECISQLSLSG PNAPVPVDFL ENQVTIQNLQ LQVKESSNEN LRLLHVIEER DKKVESLLNE
     IKELDSKLDF QEAQITTKTE ACVELEKIVG KLKKEKSDLR ERLESFACDN QELHQRTESL
     EGLNSNLETG TDKRSHAVIE DNVADVNDNW RERFLDAEKE LKRIQFEKGN MEHHALSVEA
     NLETVQTEKL YLEKDNESKQ KVITRLEEEL SVVTNERNQL HGELDTLSKE NKELDLMSEK
     MKEKICELES HQDECLHHID VAEAELRDKA QLIQTLSSNV TELSEENTRL QEQLQSLEKD
     SQALTLVKSE LEIQIEQLNK EKESLAGESE SLQTRLHESE HEKLTIAKAL EDALMEKGEV
     AVRLSSTQEE VHQLRKGIEK LRVRIEADDK KQLHVLEKLR ASERKSDSLQ DKVENLEREL
     QMSEENQELV ILDAENSKAE VEALKTQMEL MTKTLKDLEL DLGTVKFEKE NLIKQLQEKQ
     GQVSELDTLL SSLKSRLEEE EKEKIETREE SKAALEMLQT QLKELNEEVI ALCHDQEIQK
     VEEQSMDTSG QKIHQLRNSI EKLKVRLEAD EKEQLQVLGK LKESEHHADL LKDRVEKLER
     ELEISGKNQE RMILEAENSK AEVGTLKAKI EEMAQNLRDL ELDLVHVRSE KENVIEELQK
     EQGRVSELEI LKSSFENLLQ EKEQEKVQMR EDSKIAVEML QTQVKELNQK VEALGHDQDA
     WKAQAQNLHS QVDALELEKA QLLQDLDEVK NNYLNVQSSA NGLLQQVEDG KHKLEKKEEE
     ISLLKNQIQD REQLTSKLAQ VEGEQQLWKK QKGELENLLV ELEQKSQGLQ AKNDTLQDTL
     EALQRSHKDL EKELELTKIE NMSFVEKVKA MTGKETELQR EMHEMVQKTT ELKEEFTRER
     NRLTEELNIM SEDIKSSKGQ LKELMLENSE LKKSLDCIHK DQMEKEEKVR EEIAEYQLQL
     QEAEKKHQTL LLDINKQYEM EIQTYREKLS SQEECLSLQK AEVDLLKSSK EELNNSLKAT
     TKILEELKKT QADNVKYANQ LKKENERAQG KIKLLIKSCK QLEEEKEMLQ KELSKLEAAQ
     EKQKTGTAVD SNAEELMAEI KELKETLEEK NKEADEYLDK YCSLLISHEK LEKAKEMLET
     QVARLSSRSK LNLQNSPLLN SVVSEDSPAP SATEKKLSSS QNKTSGKRQR STGIREDGGG
     TAPSTPETFS KKSRKAVKSG IHPTEDTRDT EFEPEGLPEV VKKGFADIPT GKTSPYVLRR
     TTMPTRTSPR LAAQKLVPSP LSLNKENQAE TSQPTAGGSR SQKVKVAQQS PVDSSASFRE
     PTTRSLSVSN LPERSPADSP REGLRAKRGR LAPSPEAVPE SKSSENCRVQ
//
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