ID M3XWB3_MUSPF Unreviewed; 2311 AA.
AC M3XWB3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=ATP binding cassette subfamily A member 4 {ECO:0000313|Ensembl:ENSMPUP00000003363.1};
GN Name=ABCA4 {ECO:0000313|Ensembl:ENSMPUP00000003363.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000003363.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000003363.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AEYP01031842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9669.ENSMPUP00000003363; -.
DR Ensembl; ENSMPUT00000003429.1; ENSMPUP00000003363.1; ENSMPUG00000003394.1.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000155624; -.
DR HOGENOM; CLU_000604_19_0_1; -.
DR InParanoid; M3XWB3; -.
DR OMA; EVHQSMG; -.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005502; F:11-cis retinal binding; IEA:Ensembl.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005503; F:all-trans retinal binding; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0140347; F:N-retinylidene-phosphatidylethanolamine flippase activity; IEA:Ensembl.
DR GO; GO:0090555; F:phosphatidylethanolamine flippase activity; IEA:Ensembl.
DR GO; GO:0006649; P:phospholipid transfer to membrane; IEA:Ensembl.
DR GO; GO:0045332; P:phospholipid translocation; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:0042574; P:retinal metabolic process; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR005951; ABCA4/ABCR.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01257; rim_protein; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF190; RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 731..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1680..1702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1722..1748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1760..1779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1791..1813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 929..1160
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1938..2170
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1297..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2289..2311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2311 AA; 260804 MW; AF9AE741B00EB9B8 CRC64;
MGFVRQIQLL LWKNWTLRKR QKIRFVVELA WPLSLFLILI WLRNINPLYS QHECHFPNKA
MPSAGMLPWL QGIFCNVNNP CFQSPTPGES PGTVSNYNNS ILARVFRDFQ ELVMKAPERQ
NLGHVWKELQ TLSQLMDTLR THPERVAGRG IRIRDVLKDE ETLTLFLTRN IGLSDSVVYL
LVNSQVRPEQ FAHGVPDLML KDIACSETLL RRFIIFSQRH GAQTVRDAMC SLSQGTLQWV
EDTLYANVDF FKLFRVLPTL LDSSSQGINL RSWGRIFSDM SPRIQEFIHR PSVQDLLWVA
RPLMQTGGPE TFTQLMSVLS DLLCGYPEGG GSRVFSFNWY EDNNYKAFLG IDSTRKDPIY
SYDKRTTTFC NALIQSLESN PLTKIAWRAA KPLLMGKILF TPDSPAARRI LKNANSTFEE
LERLRKLVKA WEEVGPQIWY FFDKSTQMTM IRDTLENPTV KAFLNNQLGE EGITVEAVLN
FLDRGPRENQ ANDVANLNWK DVFNITDHTL RLASRYLECL ILDKFESYDD EIQLTQRALS
LLEENRFWAG VVFPDMYPWT SALPPHVKYK IRMDIDVVEK TNKIKDRYWD SGPRADPVED
FRYIWGGFAY LQDMIERGIT RSQAQVEVPV GIYLQQMPYP CFVDDSFMII LNRCFPIFMV
LAWIYSVSMT VKSIVLEKEL RLKETLKNQG VSNAVIWCTW FLDSFSIMSM SIFLLTIFIM
HGRILHYSDP FILFLFLLTF STATIMQCFL LSTFFSRASL AAACSGVIYF TLYLPHILCF
AWQDRMTADL KMAVSLLSPV AFGFGTEYLA RFEEQGLGLQ WNNIGRSPME GDEFSFLMSM
KMMLLDAALY GLLAWYLDQV FPGDYGTPLP WYFLLQESYW LGGEACSTRE ERALEKTEPI
TEEMEDPGHP EGINDSFFER ELPGLVPGVC VKNLVKIFDT YSRPAVDRLN ITFYENQITA
FLGHNGAGKT TTLSILTGLL PPTSGTVLIG GKDIETSLDE VRQSLGMCPQ HNILFHHLTV
AEHILFYAQL KGKSWEEAQL EMEAMLEDTG LHHKRNEEAQ DLSGGMQRKL SVAIAFVGGA
KVVILDEPTS GVDPYSRRSI WDLLLKYRSG RTIIMSTHHM DEADLLGDRI AIISQGRLYC
SGTPLFLKNC FGTGFYLTLV RKMKNIQSQR TGYEGNCSCA SEGFSSRCPA HIDEITPEQV
LDGDVNELMD MIQHHVPEAK LVECIGQELI FLLPNKNFKQ RAYASLFREL EDTLADLGLS
SFGISDTPLE EIFLKVTEDS DSGPLFAGGT HQKRENVSLQ HPWLGPKDKA RQIPQGSDGC
SAEPAPPRGG QPSSEPEPEH RSRLNTGAPL LLQHVQALLI KRFHHTVRSH KDFLAQIVLP
ATFVFLALML SLIVPPFGEY PALTLHPWMY GQQYTFFSLD QPGSEQLAAL ADILLNKPGF
GNRCLKEEWL PEYPCVNSTP WKTPSVSPNI THLFQKQKWT PEDPSPSCMC STREKLTMLP
ECPEGAGGLP PPQRIQRSTE VLQDLTNRNI SDFLVKTYPS LIRSSLKSKF WVNEQRYGGI
SIGGKLPVLP ITGVNVSGVC KQPGDLGRTF DGPITREASK EMPAFLKHLE TEDNIKVWFN
NKGWHALVSF LNVAHNAILR TSLHKDKNPE EYGITVISQP LNLTKEQLSE ITVLTTSVDA
VVAICVIFAM SFVPASFVLY LIQERVNKAK HLQFVSGVSP TTYWLTNFLW DIMNYAVSAA
LVVGIFIGFQ KKAYTSPENL PALVALLMLY GWAVIPMMYP ASFLFDIPST AYVALSCANL
FIGINSSAIT FILELFENNQ TLLRFNAMLR KLLVIFPHFC LGRGLIDLAL SQAVTDVYAR
FGEEHSTNPF QWDLIGKNLV AMAAEGVVYF LLTLLIQHHF FLTRWIAEPA KEPIIDEDDD
VAEERQRIIS GGNKTDILRL NELTKIYSGT SSPAVDRLCV GVRPGECFGL LGVNGAGKTT
TFKMLTGDTT VTSGDATIAG KSILTNISDV HQNMGYCPQF DAIDDLLTGR EHLYLYARLR
GVPADEIERV ANWSIQSLGL SLYADRLVGT YSGGNKRKLS TAIALMGCPP LVLLDEPTTG
MDPQARRMLW NTIVSIIREG RAVVLTSHSM EECEALCTRL AIMVKGTFQC LGTIQHLKCK
FGDGYIVTMK IRSPKEDLLP DLNPVEQFFQ GNFPGSVQRE RHYNMLQFQV SSSSLARIFR
LLISHKDSLL IEEYSVTQTT LDQVFVNFAK QQTEIHDLPL HPRAAGASRQ AKVLLLLFHS
PLSEADPQLR DWYAGSEGPQ GPDMPPTESP P
//
