ID M3XWV5_MUSPF Unreviewed; 1733 AA.
AC M3XWV5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Methyl-CpG binding domain protein 5 {ECO:0000313|Ensembl:ENSMPUP00000003555.1};
DE SubName: Full=Methyl-CpG-binding domain protein 5 isoform X1 {ECO:0000313|RefSeq:XP_004757934.1, ECO:0000313|RefSeq:XP_012914502.1};
GN Name=MBD5 {ECO:0000313|Ensembl:ENSMPUP00000003555.1,
GN ECO:0000313|RefSeq:XP_004757934.1, ECO:0000313|RefSeq:XP_012914502.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000003555.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000003555.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004757934.1, ECO:0000313|RefSeq:XP_012914502.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004757934.1,
RC ECO:0000313|RefSeq:XP_012914502.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01044344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01044345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01044346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01044347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01044348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01044349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004757934.1; XM_004757877.3.
DR RefSeq; XP_012914502.1; XM_013059048.2.
DR STRING; 9669.ENSMPUP00000003555; -.
DR Ensembl; ENSMPUT00000003622.1; ENSMPUP00000003555.1; ENSMPUG00000003584.1.
DR GeneID; 101687623; -.
DR KEGG; mpuf:101687623; -.
DR CTD; 55777; -.
DR eggNOG; ENOG502QTC7; Eukaryota.
DR GeneTree; ENSGT00530000064137; -.
DR HOGENOM; CLU_003105_0_0_1; -.
DR OMA; WDGETQH; -.
DR OrthoDB; 5404763at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd20141; PWWP_MBD5; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR16112; METHYL-CPG BINDING PROTEIN, DROSOPHILA; 1.
DR PANTHER; PTHR16112:SF18; METHYL-CPG-BINDING DOMAIN PROTEIN 5; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 11..81
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1624..1648
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 123..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1584..1614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1708..1733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..346
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1733 AA; 184238 MW; BBC99118A668119D CRC64;
MNGGKDCDGG DKDGGLPAIQ VPVGWQRRVD QNGVLYVSPS GSLLSCLEQV KTYLLTDGTC
KCGLECPLIL PKVFNFDPGA AVKQRTAEDV KADEDVTKLC IHKRKIIAVA TLHKSMEAPH
PSLVLTSPGG GTNATPVVPS RAATPRSVRN KSHEGITNSV MPECKNPFKL MIGSSNAMGR
LYVQELPGSQ QQELHPVYPR QRLGSSEHGQ KSPFRGSHGG LPSPASSGSQ IYGDGSISPR
TDPLGSPDVF TRSNPGFHGA PNSSPIHLSR TPLSPPSVML HGSPVQSSCA MAGRTNIPLS
PTLTTKSPVM KKPMCNFSTN MEIPRAMFHH KPPQGPPPPP PPSCALQKKP LTSEKDPLGI
LDPIPSKPVN QNPVIINPTS FHSNVHSQVP VMNVSMPPAV VPLPSNLPLP TVKPGHMNHG
SHIQRVQHSA STSLSPSPVT SPVHMMGTGI GRIEASPQRS RSSSTSSDHG NFMMPPLGPQ
ATCSGIKVPP RSPRSTIGSP RPSMPSSPST KSDGHHQYKD IPNPLIAGMS NVLNTPSSAA
FPTASAGSGS VKSQPGLLGM PLNQILNQHN AASFPASSLL SAAAKAQLAN QNKLAGNNCS
SSSNSGAVAG SGNTEGHSTL NTMFPPTANM LLPTGEGQSG RAALRDKLMS QQKDSLRKRK
QPPTTVLSLL RQSQMDSSAV PKPGPDLLRK QGQGSFPISS MSQLLQSMSC QSSHLSSNST
PGCGGSNTAL PCSANQLHFT DLNMNSSALQ NSLTQTIPLR GEAVHCHNAN TNFVHNNSPV
PNHHLAGLIN QIQASGNCGM LSQSGMALGN SLHPNPPQSR ISTSSTPVIP NSIVSSYNQT
SSEAGGSGPS SSIAIAGTNH PAITKTTSVL QDGVIVTTAA GNPLQSQLPI GSDFPYVGQE
HALHFPSNST SNNHLPHPLN PSLLSSLPIS LPVNQQHLLN QNLLNILQPS AGEGKSEINL
HPLGFLNPNV NTALAFLSGD MDGQVLQPVH FQLLAALLQN QAQAAAMLPL PSFNMTISDL
LQQQNTPLPS LSQMTAPPDH LPSNQSENSR AETLLTSPLG NPLPSFAGSD TTFNPLFLPA
VTGASGLMAL NPQLLGGVLN SASANTANHP EVSIATSSQA TTTTTTTSSA VAALTVSTLG
GTAVVSMAET LLNISNNAGN TPGPAKLNSN SVVPQLLNPL LGTGLLGDMS SINNSLNNHQ
LTHLQSLLNN NPMFPPNQQQ QQQLLQGYQN LQAFQGQPTI PCTANSNPMA CLFQNFQVRM
QEDAAILNKR ISTQPGLTAL PENPNTTLPP FQDTSCELQQ RIDPSLGQQV KDGLVVSGQG
DASVDAIYKA VVDAASKGMQ VVITTAVNST TQISPIPALS AMSAFTASIG DPLSLPSAVS
AVIHGRNMGS VDHDGRLRNA RGARLPRNLD HGKNSNEGDG FEYFKSASCH TSKKQWDGEQ
SPGGEQNRWK CEEFLDHPGH IHSSPCHERS NNVSTLPFLP GEQHPVLLPP RNCQGDKILE
ENFRYNNYKR TMMSFKERLE NTVERCAHIN GNRPRQSRGF GELLSTTRQD LVLEEQSPSS
SNSLESSLVK DYIHYNGDFN AKSINGCVPS PSDAKSISSE DDLRNPDSPS SNELIHYRPR
TFNVGDLVWG QIKGLTSWPG KLVREDDVHN SCQQSPEEGK VEPEKLKTLT EGLEAYSRAR
KRNRKSGKLN NHLEAAIHEA MSELDKMSGT VHQIPQGDRQ MRPPKPKRRK ISR
//
