UniProt: M3XWW2

Database: UniProt
Entry: M3XWW2_MUSPF

LinkDB:  M3XWW2_MUSPF 
Original site:  M3XWW2_MUSPF

All links

Ontology (11)   
   GO (11)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (18)   
   RefSeq(pep) (18)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (8)   
   InterPro (5)   
   Pfam (2)   
   SMART (1)   
All databases (43)   

Download RDF

ID   M3XWW2_MUSPF            Unreviewed;       436 AA.
AC   M3XWW2;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083, ECO:0000256|PIRNR:PIRNR007858};
GN   Name=ORC4 {ECO:0000313|Ensembl:ENSMPUP00000003562.1,
GN   ECO:0000313|RefSeq:XP_004757926.1, ECO:0000313|RefSeq:XP_012914506.1,
GN   ECO:0000313|RefSeq:XP_012914507.1, ECO:0000313|RefSeq:XP_012914508.1,
GN   ECO:0000313|RefSeq:XP_012914509.1, ECO:0000313|RefSeq:XP_012914514.1,
GN   ECO:0000313|RefSeq:XP_044922481.1, ECO:0000313|RefSeq:XP_044922482.1,
GN   ECO:0000313|RefSeq:XP_044922483.1, ECO:0000313|RefSeq:XP_044922484.1,
GN   ECO:0000313|RefSeq:XP_044922485.1, ECO:0000313|RefSeq:XP_044922486.1,
GN   ECO:0000313|RefSeq:XP_044922487.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000003562.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000003562.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004757926.1, ECO:0000313|RefSeq:XP_012914506.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004757926.1,
RC   ECO:0000313|RefSeq:XP_012914506.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. {ECO:0000256|PIRNR:PIRNR007858}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR007858}.
CC   -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000256|ARBA:ARBA00005334,
CC       ECO:0000256|PIRNR:PIRNR007858}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AEYP01044373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004757924.1; XM_004757867.2.
DR   RefSeq; XP_004757926.1; XM_004757869.3.
DR   RefSeq; XP_012914506.1; XM_013059052.2.
DR   RefSeq; XP_012914507.1; XM_013059053.2.
DR   RefSeq; XP_012914508.1; XM_013059054.2.
DR   RefSeq; XP_012914509.1; XM_013059055.2.
DR   RefSeq; XP_012914510.1; XM_013059056.1.
DR   RefSeq; XP_012914511.1; XM_013059057.1.
DR   RefSeq; XP_012914512.1; XM_013059058.1.
DR   RefSeq; XP_012914513.1; XM_013059059.1.
DR   RefSeq; XP_012914514.1; XM_013059060.2.
DR   RefSeq; XP_044922481.1; XM_045066546.1.
DR   RefSeq; XP_044922482.1; XM_045066547.1.
DR   RefSeq; XP_044922483.1; XM_045066548.1.
DR   RefSeq; XP_044922484.1; XM_045066549.1.
DR   RefSeq; XP_044922485.1; XM_045066550.1.
DR   RefSeq; XP_044922486.1; XM_045066551.1.
DR   RefSeq; XP_044922487.1; XM_045066552.1.
DR   STRING; 9669.ENSMPUP00000003562; -.
DR   Ensembl; ENSMPUT00000003629.1; ENSMPUP00000003562.1; ENSMPUG00000003591.1.
DR   GeneID; 101686292; -.
DR   KEGG; mpuf:101686292; -.
DR   CTD; 5000; -.
DR   eggNOG; KOG2228; Eukaryota.
DR   GeneTree; ENSGT00390000016542; -.
DR   HOGENOM; CLU_007115_0_1_1; -.
DR   OMA; ETKFRHH; -.
DR   OrthoDB; 230201at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:Ensembl.
DR   GO; GO:0000166; F:nucleotide binding; IEA:Ensembl.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:Ensembl.
DR   GO; GO:0040038; P:polar body extrusion after meiotic divisions; IEA:Ensembl.
DR   GO; GO:0051258; P:protein polymerization; IEA:Ensembl.
DR   CDD; cd00009; AAA; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR016527; ORC4.
DR   InterPro; IPR032705; ORC4_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR   PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF14629; ORC4_C; 1.
DR   PIRSF; PIRSF007858; ORC4; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|PIRNR:PIRNR007858};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR007858};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR007858};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT   DOMAIN          59..202
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   436 AA;  50414 MW;  839537DBC16EB5F3 CRC64;
     MSSRKSKSNN LIHAEYLSQV QGILRERFCH QSPHSNLFGV QVQYKHLIEL LKRTAIHGES
     NSVLIIGPRG SGKTTLINHA LKELMEVEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL
     ENVVGDKVFG SFAENLSFLL EALKKGDRSS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS
     QSAQTPLAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYLKIF KEQLSLPAEF
     PDKIFTERWN ENVQGLTEDR SVREVLQKHF NLNKNLRSLH MLLMLALNRV TTSHPFMTAA
     DLMEANQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK
     AHSVYNFEKP VVMKAFEHLQ QLELIRPVER TSVNTQREYQ LMKLLLDNTQ IMNALQKYPN
     CPTDVRQWAT SSLSWL
//

DBGET integrated database retrieval system