ID M3XWW2_MUSPF Unreviewed; 436 AA.
AC M3XWW2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083, ECO:0000256|PIRNR:PIRNR007858};
GN Name=ORC4 {ECO:0000313|Ensembl:ENSMPUP00000003562.1,
GN ECO:0000313|RefSeq:XP_004757926.1, ECO:0000313|RefSeq:XP_012914506.1,
GN ECO:0000313|RefSeq:XP_012914507.1, ECO:0000313|RefSeq:XP_012914508.1,
GN ECO:0000313|RefSeq:XP_012914509.1, ECO:0000313|RefSeq:XP_012914514.1,
GN ECO:0000313|RefSeq:XP_044922481.1, ECO:0000313|RefSeq:XP_044922482.1,
GN ECO:0000313|RefSeq:XP_044922483.1, ECO:0000313|RefSeq:XP_044922484.1,
GN ECO:0000313|RefSeq:XP_044922485.1, ECO:0000313|RefSeq:XP_044922486.1,
GN ECO:0000313|RefSeq:XP_044922487.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000003562.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000003562.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004757926.1, ECO:0000313|RefSeq:XP_012914506.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004757926.1,
RC ECO:0000313|RefSeq:XP_012914506.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. {ECO:0000256|PIRNR:PIRNR007858}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR007858}.
CC -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000256|ARBA:ARBA00005334,
CC ECO:0000256|PIRNR:PIRNR007858}.
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DR EMBL; AEYP01044373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004757924.1; XM_004757867.2.
DR RefSeq; XP_004757926.1; XM_004757869.3.
DR RefSeq; XP_012914506.1; XM_013059052.2.
DR RefSeq; XP_012914507.1; XM_013059053.2.
DR RefSeq; XP_012914508.1; XM_013059054.2.
DR RefSeq; XP_012914509.1; XM_013059055.2.
DR RefSeq; XP_012914510.1; XM_013059056.1.
DR RefSeq; XP_012914511.1; XM_013059057.1.
DR RefSeq; XP_012914512.1; XM_013059058.1.
DR RefSeq; XP_012914513.1; XM_013059059.1.
DR RefSeq; XP_012914514.1; XM_013059060.2.
DR RefSeq; XP_044922481.1; XM_045066546.1.
DR RefSeq; XP_044922482.1; XM_045066547.1.
DR RefSeq; XP_044922483.1; XM_045066548.1.
DR RefSeq; XP_044922484.1; XM_045066549.1.
DR RefSeq; XP_044922485.1; XM_045066550.1.
DR RefSeq; XP_044922486.1; XM_045066551.1.
DR RefSeq; XP_044922487.1; XM_045066552.1.
DR STRING; 9669.ENSMPUP00000003562; -.
DR Ensembl; ENSMPUT00000003629.1; ENSMPUP00000003562.1; ENSMPUG00000003591.1.
DR GeneID; 101686292; -.
DR KEGG; mpuf:101686292; -.
DR CTD; 5000; -.
DR eggNOG; KOG2228; Eukaryota.
DR GeneTree; ENSGT00390000016542; -.
DR HOGENOM; CLU_007115_0_1_1; -.
DR OMA; ETKFRHH; -.
DR OrthoDB; 230201at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:Ensembl.
DR GO; GO:0000166; F:nucleotide binding; IEA:Ensembl.
DR GO; GO:0006270; P:DNA replication initiation; IEA:Ensembl.
DR GO; GO:0040038; P:polar body extrusion after meiotic divisions; IEA:Ensembl.
DR GO; GO:0051258; P:protein polymerization; IEA:Ensembl.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR PIRSF; PIRSF007858; ORC4; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR007858};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR007858};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR007858};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 59..202
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 436 AA; 50414 MW; 839537DBC16EB5F3 CRC64;
MSSRKSKSNN LIHAEYLSQV QGILRERFCH QSPHSNLFGV QVQYKHLIEL LKRTAIHGES
NSVLIIGPRG SGKTTLINHA LKELMEVEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL
ENVVGDKVFG SFAENLSFLL EALKKGDRSS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS
QSAQTPLAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYLKIF KEQLSLPAEF
PDKIFTERWN ENVQGLTEDR SVREVLQKHF NLNKNLRSLH MLLMLALNRV TTSHPFMTAA
DLMEANQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK
AHSVYNFEKP VVMKAFEHLQ QLELIRPVER TSVNTQREYQ LMKLLLDNTQ IMNALQKYPN
CPTDVRQWAT SSLSWL
//