ID M3XYN1_MUSPF Unreviewed; 1610 AA.
AC M3XYN1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=IQ motif containing GTPase activating protein 3 {ECO:0000313|Ensembl:ENSMPUP00000004182.1};
GN Name=IQGAP3 {ECO:0000313|Ensembl:ENSMPUP00000004182.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000004182.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000004182.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
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DR EMBL; AEYP01094695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9669.ENSMPUP00000004182; -.
DR Ensembl; ENSMPUT00000004257.1; ENSMPUP00000004182.1; ENSMPUG00000004216.1.
DR eggNOG; KOG2128; Eukaryota.
DR GeneTree; ENSGT00950000183076; -.
DR HOGENOM; CLU_000972_2_1_1; -.
DR InParanoid; M3XYN1; -.
DR OMA; RELMCPE; -.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:0070856; F:myosin VI light chain binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0071310; P:cellular response to organic substance; IEA:Ensembl.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0033598; P:mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF10; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP3; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
FT DOMAIN 14..129
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 643..676
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 967..1200
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1375..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1380..1400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1610 AA; 181002 MW; 97C8EDF072EAD672 CRC64;
MDEQRRQNVA YQYLCRLEEA KRWMEACLKE ELPSPVELEE SLRNGVLLAK LGHCFAPAVV
PLKKIYDAEQ LRYQATGLHF RHTDNINFWL SAVAHIGLPS TFLPETTDIY DKKNMPRAIY
CIHALSLFLF RLGLAPQIHD LYGKVKFSAE ELSNMAAELA KYGLQLPAFS KIGGILASEL
SVDQAAVHAA VLAINEAVER GVVEDTLAAL QNPNALLGNL REPLAAIYQE LLAQAKAEKA
ASAQTCGGRE SWDVYDRFLT QAEIQGNINH VNVHGALEAV DDALERQSPE ALLEALLDPA
LALQGLRRNF AGWYLEQLSS DREQKAQELG LLELLEKEEV QAGVAAANMK GDQEQAMLQA
VCRINRAIQR GVAAATVEEL MCPEAQLPPV YPSAPAVYQQ ELRALQQQRG GELGHEELFV
AVEMLSAVVL INQALEAGDV GGFWSSLVNP ASGLAEVERE NAQRYFDGLA ELRRALAGAI
LSWNDLQATV HRVNAQVQEE TDQVLAVSLI NEALDQGSPE KTLSALLLPS AGLEDISLPV
APQYHLLLVA AKRQKAQATG DPGALLWLEE IRQEVVRANQ DTDAAQRMAL GVAAINQAIR
EGKAGQTERV LRNPAVALRG VVPNCADSYQ RVLEAAMAKK RHPGAPALWV RHGMKDGSAY
YFHLQTLQGT WEPPSGCRLN TSHLTREEIQ LAVTKVTTAH DRQQLWKANI GFVIRLQARL
RGFLVRQEFA ERAHFLRTWL PAVVKIQAHW RGYRQRKAYL ERLQYFRAHS DAVIKIQAWA
RAWAARRRYR RRLGFFQENV ESIVKIQAFF RARKARDDYR TLVHAAHPPL RLVCKFAHLL
NQSQEDFLAE AELLKLQEEV VRKIRSNQQL QQDLNLMDIK IGLLVKNRVT LQELVSHCKK
LTKKNKEQLA GLMVLDRQRG LKSLSKEKRQ KLEAYQHLLY LLQTQPIYLA RLIFHMPQSK
TTKFMESVVF SLYNYASSRR EAYLLLQLFK TALQEEIRSK VERPQDMVTG DPTVVRLVVR
FYRNGRGQSA LREILGRVIQ DVLGDKTLSV HTDPVHLYKS WVNQSEAQTG QRSHLPYDVT
PEQALSHPEV QRRLDISLRS LLALTDRFLA AIMSSVEHIP YGMRYVAKVL KTTLAERFPA
ASEDEVYKVV GNLLYYRFLN PAVVAPDAFD IVAVAAGGAL APSQRHTLGA VAQVLQHAAA
GKAFSGPSRH LRALNDYLED THIKFRRFMC RACRVPEPEE RFAMDEYSDM VAVAKPVVYI
TVGELLNTHR LLLEHQDWVA PEHCDPLHEL LEDLGELPTV SDLIGEGVAA AGNKDPAKLE
VSLTLTNKFE GVETDAGDTG AQSLLLSTKQ MLADIMQFQP GDSLQEMLSL PATAEQEAAH
KQLTAERQAR ESQTPEPLRR HRSLSAHALL PLADKRRRVL RNLRRLESLG LVSARDGYQG
LVDGLAKDIR NQRRHRQRRK AELGKLQVTL QGLDAKTAFY EEQGDYYSQY IRACLDQLAP
RCTSSGKGKK RPALRYTAAQ LLEKGVLVEI EDLPTSHFRN VIFDITPGDE AGKFEVNTKF
LGVDMERFQL HYQDLLQLQY EGVAVMKLFN KAKVNVNLLI FLLNKKLLRQ
//