ID M3XYQ0_MUSPF Unreviewed; 454 AA.
AC M3XYQ0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=Myocyte enhancer factor 2D {ECO:0000313|Ensembl:ENSMPUP00000004201.1};
GN Name=MEF2D {ECO:0000313|Ensembl:ENSMPUP00000004201.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000004201.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000004201.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AEYP01094696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01094697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XYQ0; -.
DR STRING; 9669.ENSMPUP00000004201; -.
DR Ensembl; ENSMPUT00000004276.1; ENSMPUP00000004201.1; ENSMPUG00000004235.1.
DR eggNOG; KOG0014; Eukaryota.
DR GeneTree; ENSGT00940000159463; -.
DR HOGENOM; CLU_022902_4_0_1; -.
DR InParanoid; M3XYQ0; -.
DR OMA; NISAWHQ; -.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0007512; P:adult heart development; IEA:Ensembl.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; Transcription factor, MADS-box; 1.
DR InterPro; IPR022102; HJURP_C.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR PANTHER; PTHR11945; MADS BOX PROTEIN; 1.
DR PANTHER; PTHR11945:SF23; MYOCYTE-SPECIFIC ENHANCER FACTOR 2D; 1.
DR Pfam; PF12347; HJURP_C; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SRF-like; 1.
DR PROSITE; PS00350; MADS_BOX_1; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..61
FT /note="MADS-box"
FT /evidence="ECO:0000259|PROSITE:PS50066"
FT REGION 174..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..396
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 48435 MW; E1030F9B549058BC CRC64;
MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST
DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA
SEELDGLFRR YGSAVPAPNF AMPVTVPVSS QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS
PQQPALQRNS VSPGLPQRPA SAGESPGAML GGDLNSANGA CPSPVGNGYV SARASPGLLP
VANGSTLNKG IPAKSPPPPT HGAQLGAPSR KPDLRVITSQ GGKGLMHHLF CSQTEDHLDL
NNAQRLGASQ STHSLTTPVV SVATPSLLSQ GLPFSSMPTA YNTDYQLSSA ELSSLPTFSS
PGGLSLGSVT AWPQPTQPPS RERSPAPPPP AVFPATRPEP GDGLSSPASG SYETGDRDDG
RGDFGPTLGL LRPAQEPEAE GPAVKRMRLD TWVL
//
