ID M3XYS5_MUSPF Unreviewed; 464 AA.
AC M3XYS5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=GDNF family receptor alpha-2 {ECO:0000256|ARBA:ARBA00016726, ECO:0000256|PIRNR:PIRNR038071};
DE Short=GDNF receptor alpha-2 {ECO:0000256|PIRNR:PIRNR038071};
GN Name=GFRA2 {ECO:0000313|Ensembl:ENSMPUP00000004226.1,
GN ECO:0000313|RefSeq:XP_004763384.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000004226.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000004226.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004763384.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004763384.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for neurturin. Mediates the NRTN-induced
CC autophosphorylation and activation of the RET receptor. Also able to
CC mediate GDNF signaling through the RET tyrosine kinase receptor.
CC {ECO:0000256|ARBA:ARBA00025392, ECO:0000256|PIRNR:PIRNR038071}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961, ECO:0000256|PIRNR:PIRNR038071}.
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DR EMBL; AEYP01057782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01057783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01057784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004763384.1; XM_004763327.3.
DR STRING; 9669.ENSMPUP00000004226; -.
DR Ensembl; ENSMPUT00000004302.1; ENSMPUP00000004226.1; ENSMPUG00000004261.1.
DR GeneID; 101683885; -.
DR KEGG; mpuf:101683885; -.
DR CTD; 2675; -.
DR eggNOG; ENOG502QS3P; Eukaryota.
DR GeneTree; ENSGT00940000156168; -.
DR HOGENOM; CLU_040179_1_1_1; -.
DR OMA; DTGKPCN; -.
DR OrthoDB; 3899332at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003504; GDNF_rcpt_a2.
DR InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR PANTHER; PTHR10269:SF4; GDNF FAMILY RECEPTOR ALPHA-2; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR PRINTS; PR01318; GDNFRALPHA2.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR038071};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038071};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR038071};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR038071}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|PIRNR:PIRNR038071"
FT CHAIN 22..464
FT /note="GDNF family receptor alpha-2"
FT /evidence="ECO:0000256|PIRNR:PIRNR038071"
FT /id="PRO_5041500596"
FT DOMAIN 40..117
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 161..241
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 251..347
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT REGION 363..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 51556 MW; 1C48755F88A52CD4 CRC64;
MILANTFCLL FFLDETLRSL ASPSSPQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL
RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE
EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPAVSPKSNH CLDAAKACNL NDNCKKLRSS
YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS
CSYEDKEKPN CLDLRSVCRT DHLCRSRLAD FHANCRASYQ TLTSCPADNY QACLGSYAGM
IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD
VNLSPKNPPF QATQAPRVEK APSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM
CFTELTTNII PGSNKVIKPN SGPCRATPSA ALTAVSFLML KLAL
//
