ID M3XZ92_MUSPF Unreviewed; 539 AA.
AC M3XZ92;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Glycerophosphodiester phosphodiesterase domain containing 2 {ECO:0000313|Ensembl:ENSMPUP00000004393.1};
DE SubName: Full=Glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1 {ECO:0000313|RefSeq:XP_004777252.1};
GN Name=GDPD2 {ECO:0000313|Ensembl:ENSMPUP00000004393.1,
GN ECO:0000313|RefSeq:XP_004777252.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000004393.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000004393.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004777252.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004777252.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC family. {ECO:0000256|ARBA:ARBA00007277}.
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DR EMBL; AEYP01090328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004777252.1; XM_004777195.3.
DR STRING; 9669.ENSMPUP00000004393; -.
DR Ensembl; ENSMPUT00000004469.1; ENSMPUP00000004393.1; ENSMPUG00000004426.1.
DR GeneID; 101674035; -.
DR KEGG; mpuf:101674035; -.
DR CTD; 54857; -.
DR eggNOG; KOG2258; Eukaryota.
DR GeneTree; ENSGT00940000159625; -.
DR HOGENOM; CLU_024259_3_0_1; -.
DR OMA; DPPGCCS; -.
DR OrthoDB; 203377at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR PANTHER; PTHR23344:SF1; GLYCEROPHOSPHOINOSITOL INOSITOLPHOSPHODIESTERASE GDPD2; 1.
DR PANTHER; PTHR23344; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR Pfam; PF03009; GDPD; 1.
DR Pfam; PF13653; GDPD_2; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS51704; GP_PDE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 224..479
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
SQ SEQUENCE 539 AA; 61557 MW; 6E19897814CCEE60 CRC64;
MAESPGCCSV WARCLHCLYS CHWRKCPKER MQTSKCDCIW FGLLFLTFLL SLGWLYIGLI
LLNDLHNFNE FLFHHWGHWM DWSLAFLLVI SLLVTYASLL LLLALLLRLC GQPLHLHSVH
KMLLLLIMLL VAAGLVGLDV QWQQEWRSLR LSLQATAPFL HIGAVAGITL LAWPVADTFY
RIHRRGPKTL LLFLFFGVSL AVYLAPLCIS SPCIMEPRDL PPKPGLVGHR GAPMLAPENT
LMSLRKTAEC GAAVFETDVM VSSDGIPFLM HDEHLSRTTD VASVFPARTS SHSSDFSCAE
LKKLNAGTWF LERQPFWGAK RLSGPDRKEA ENQTVPTLEE LLKEAAVLNL SIMFDLRRPP
RNHTYHDTFV NQTLETVLSA RVPQAMVLWL PDEDRANVQQ RAPRMRQIYG QQGSNRTERP
QFLNLPYQDL PLLDIKALHQ DNVSVNLFVV NKPWLFSLLW CAGVDSVTTN DCQLLQQMRY
PVWIIPPQTY LMMWVITNCV STLLLLWTFL LQGRCKKERE KTGLETAVLL TRINNFIME
//
