ID M3XZA4_MUSPF Unreviewed; 682 AA.
AC M3XZA4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Transcription factor 12 {ECO:0000256|ARBA:ARBA00040507};
DE AltName: Full=DNA-binding protein HTF4 {ECO:0000256|ARBA:ARBA00043010};
DE AltName: Full=E-box-binding protein {ECO:0000256|ARBA:ARBA00041543};
DE AltName: Full=Transcription factor HTF-4 {ECO:0000256|ARBA:ARBA00042405};
GN Name=TCF12 {ECO:0000313|Ensembl:ENSMPUP00000004405.1,
GN ECO:0000313|RefSeq:XP_004777362.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000004405.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000004405.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004777362.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004777362.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01090538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01090539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01090540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01090541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01090542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01090543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01090544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01090545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01090546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01090547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004777362.1; XM_004777305.3.
DR STRING; 9669.ENSMPUP00000004405; -.
DR Ensembl; ENSMPUT00000004481.1; ENSMPUP00000004405.1; ENSMPUG00000004438.1.
DR GeneID; 101678243; -.
DR CTD; 6938; -.
DR eggNOG; KOG3910; Eukaryota.
DR GeneTree; ENSGT00940000155047; -.
DR HOGENOM; CLU_021099_2_0_1; -.
DR OMA; MNSNLMX; -.
DR OrthoDB; 2915397at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0046332; F:SMAD binding; IEA:Ensembl.
DR GO; GO:0097210; P:response to gonadotropin-releasing hormone; IEA:Ensembl.
DR CDD; cd18945; bHLH_E-protein_TCF4_E2-2; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11793; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR11793:SF11; TRANSCRIPTION FACTOR 12; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 577..630
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 25..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 682 AA; 72978 MW; D685E86F135109A0 CRC64;
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG MDERGGTTSW
GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGAHEGLSPT PFMNSNLMGK TSERGSFSLY
SRDTGLPGCQ SSLLRQDLGL GSPAQLSSSG KPGTPYYSFS ASSSRRRPLH DSTALDPLQA
KKVRKVPPGL PSSVYAPSPN SDDFNRESPS YPSPKPPTSM FASTFFMQDG THNSSDIWSS
SNGMSQPGFG GILGTSTSHM SQSSSYGSLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG
STSSSPYVAA SHTPPINGSD SILGTRGTAA GSSQTGDALG KALASIYSPD HTSSSFPSNP
STPVGSPSPL TGTSQWPRPG GQAPSSPSYE NSLHSLQSRM EDRLDRLDDA IHVLRNHAVG
PSTSLPAGHS DIHSLLGPSH NAPIGSLNSN YGGSSLVTSS RSASMVGTHR EDSVNLNGNH
SVLSSTVTAS STDLNHKTQE NYRGGLQSQS GTVVPAEIKT ENKEKDENLH EPPSSDDMKS
DDESSQKDIK VSSRGRTSST NEDEDLNPEQ KIEREKERRM ANNARERLRV RDINEAFKEL
GRMCQLHLKS EKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE EEKVSAVSAE
PPTTLPGTHP GLSETTNPMG HM
//
