ID M3Y011_MUSPF Unreviewed; 1338 AA.
AC M3Y011;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=FLT1 {ECO:0000313|Ensembl:ENSMPUP00000004662.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000004662.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000004662.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AEYP01084837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01084846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9669.ENSMPUP00000004662; -.
DR Ensembl; ENSMPUT00000004743.1; ENSMPUP00000004662.1; ENSMPUG00000004699.1.
DR eggNOG; KOG0200; Eukaryota.
DR GeneTree; ENSGT00940000158713; -.
DR HOGENOM; CLU_000288_49_4_1; -.
DR InParanoid; M3Y011; -.
DR OMA; CNENFPV; -.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019838; F:growth factor binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0036332; F:placental growth factor receptor activity; IEA:Ensembl.
DR GO; GO:0005021; F:vascular endothelial growth factor receptor activity; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0002548; P:monocyte chemotaxis; IEA:Ensembl.
DR GO; GO:1905563; P:negative regulation of vascular endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
DR InterPro; IPR041348; VEGFR-2_TMD.
DR InterPro; IPR009135; VEGFR1_rcpt.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF390; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF21339; VEGFR-1-like_Ig-like; 1.
DR Pfam; PF17988; VEGFR-2_TMD; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 2.
DR PRINTS; PR01832; VEGFRECEPTOR.
DR PRINTS; PR01833; VEGFRECEPTR1.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 6.
DR SMART; SM00406; IGv; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 5.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
PE 4: Predicted;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1338
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004044088"
FT DOMAIN 32..125
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 230..327
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 428..549
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 556..654
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 661..747
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 827..1158
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 941..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..959
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 861
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1027
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 1338 AA; 150233 MW; 51AE67482E9F1F25 CRC64;
MVSCWDTGLL LCALLGGLLL TGYSSGSKLK GPELSLKGTQ HVVQAGQTLL LRCRGEAAHS
WSLPETLRKE SKRLSIAKSA CGRNGKQFCS TLTLNAAQAN HTGFYSCKYL SIPASKKRKT
ESRIYIFIND TGRPFLEMHS EIPEIIYMTE GREIVIPCRV TSPNITVTLK KFPLDTLIPD
GKRISWDSRK GFIIANATYR EIGLLTCETT VNGHLYKSNY LTHRQTNTIQ DVQISTPSPV
KLLRGHTLTL NCTATTALNT RVQMTWKYPG KTKKRASIRQ RIGQRTSVAI VFYSVLTIDK
VQNRDKGLYT CNVKSGPSFK SVNTSVHIYD KAFIKVKHRK QHVLETTAGK RSYRLSAKVK
AFPSPEVLWL KDGFPVTEKS PRYLVHGYAL IIKDVTAEDA GDYTVLLAIK QYGVFQNLTT
TLIVNVKPQI YEKAVSSFLD PTLYLLGSRQ ILTCTIYGIP QPTVTWYWRP CNHSHSKARY
DFCSNNEESL ILDPDSNLGN RIESITQRTA VIEGKNKTAS TLVVADSRIS GIYSCMASNK
VGAVERNISF YVTDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDITWI LLRTVKNRTM
HHSISKQKMA ITKENSITLN VTIKNVSLED SGTYACRARN IYTGEEILQK KEVTIRDQEA
PHLLRNLSDH TVAISSSTTL DCHATGVPEP QITWFKNNHK IQQEPGIILG PGSSTLFIER
VTEEDEGVYH CKATNQKGSV ESSAYLTVQG TSDKSNLELI TLTCTCVAAT LFWLLLTLFI
RKLKRSSSEI KTDYLSIIMD PDEVPLDEQC ERLPYDASKW EFARERLKLG KSLGRGAFGK
VVQASAFGIK KSPTCRTVAV KMLKEGATAS EYKALMTELK ILTHIGHHLN VVNLLGACTK
QGGPLMVIVE YCKYGNLSNY LKSKRDLFFL NKDAALHVEP KTEKMEPDLE QDKKPRLDSV
TSSESFASSG FQEDKSLSDV EEEEEEIRFE LRLFTELLIL TGNCAIVSPQ GFLSKQSCLS
HTATPFNILL LKHRKISLCQ NPVEHMPFRG ERASRVLETR LPLKWMAPES IFDKIYSTKS
DVWSYGVLLW EIFSLGGSPY PGVQMDEDFC SRLKEGMRMR APQYATPEIY QIMLDCWHKD
PKERPRFAEL VEKLGDLLQA NVQQDGKDYI PLNAILTGNS GFTYSPPAFS DDFFKEDISH
PKFNSGSSDN VRYVNAFNFM SLERIKTFEE LSPNTTSIFD DYQADSSTLP ASPLLKRFTW
AESKPKASVK IALRVTSKSK ESGLSDLTPP AFCPSGCGHI NRGRRRFTYD NSELEKKIAC
CSPPPDYNSV VLYSTPPV
//
