ID M3Y0I3_MUSPF Unreviewed; 126 AA.
AC M3Y0I3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=C-type natriuretic peptide {ECO:0000256|ARBA:ARBA00018109};
GN Name=NPPC {ECO:0000313|Ensembl:ENSMPUP00000004834.1,
GN ECO:0000313|RefSeq:XP_004773523.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000004834.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000004834.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004773523.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004773523.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003686}.
CC -!- SIMILARITY: Belongs to the natriuretic peptide family.
CC {ECO:0000256|ARBA:ARBA00009041, ECO:0000256|RuleBase:RU003686}.
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DR EMBL; AEYP01081369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004773523.1; XM_004773466.3.
DR STRING; 9669.ENSMPUP00000004834; -.
DR Ensembl; ENSMPUT00000004918.1; ENSMPUP00000004834.1; ENSMPUG00000004874.1.
DR GeneID; 101681038; -.
DR KEGG; mpuf:101681038; -.
DR CTD; 4880; -.
DR eggNOG; ENOG502S2QY; Eukaryota.
DR GeneTree; ENSGT00390000015492; -.
DR HOGENOM; CLU_160791_0_0_1; -.
DR OMA; HDYPNAR; -.
DR OrthoDB; 4269066at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0051427; F:hormone receptor binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:UniProtKB-KW.
DR GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
DR GO; GO:0061939; P:c-di-GMP signaling; IEA:Ensembl.
DR GO; GO:1904588; P:cellular response to glycoprotein; IEA:Ensembl.
DR GO; GO:0006182; P:cGMP biosynthetic process; IEA:Ensembl.
DR GO; GO:0051276; P:chromosome organization; IEA:Ensembl.
DR GO; GO:0001549; P:cumulus cell differentiation; IEA:Ensembl.
DR GO; GO:0035483; P:gastric emptying; IEA:Ensembl.
DR GO; GO:0003418; P:growth plate cartilage chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0003419; P:growth plate cartilage chondrocyte proliferation; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:1903537; P:meiotic cell cycle process involved in oocyte maturation; IEA:Ensembl.
DR GO; GO:0071965; P:multicellular organismal locomotion; IEA:Ensembl.
DR GO; GO:0051447; P:negative regulation of meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1900194; P:negative regulation of oocyte maturation; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0006457; P:protein folding; IEA:Ensembl.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IEA:Ensembl.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
DR GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
DR GO; GO:0090649; P:response to oxygen-glucose deprivation; IEA:Ensembl.
DR InterPro; IPR002406; C_natriurtcpep.
DR InterPro; IPR000663; Natr_peptide.
DR InterPro; IPR030480; Natr_peptide_CS.
DR PANTHER; PTHR12167; C-TYPE NATRIURETIC PEPTIDE; 1.
DR PANTHER; PTHR12167:SF2; C-TYPE NATRIURETIC PEPTIDE; 1.
DR Pfam; PF00212; ANP; 1.
DR PRINTS; PR00713; CNATPEPTIDE.
DR PRINTS; PR00710; NATPEPTIDES.
DR SMART; SM00183; NAT_PEP; 1.
DR PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858, ECO:0000256|RuleBase:RU003686}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..126
FT /note="C-type natriuretic peptide"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041198405"
FT REGION 19..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 126 AA; 13287 MW; 0326EBF6F0BAB153 CRC64;
MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPGEEL AEPQAAGGSQ KKGDKTPGGG
GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS
MSGLGC
//
