ID M3Y149_MUSPF Unreviewed; 174 AA.
AC M3Y149;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase {ECO:0000256|ARBA:ARBA00012257};
DE EC=4.1.1.97 {ECO:0000256|ARBA:ARBA00012257};
DE AltName: Full=Parahox neighbor {ECO:0000256|ARBA:ARBA00032116};
DE AltName: Full=Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase {ECO:0000256|ARBA:ARBA00030624};
GN Name=URAD {ECO:0000313|RefSeq:XP_004774883.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005050.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000005050.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004774883.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004774883.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the stereoselective decarboxylation of 2-oxo-4-
CC hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
CC {ECO:0000256|ARBA:ARBA00002506}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-
CC carboxylate + H(+) = (S)-allantoin + CO2; Xref=Rhea:RHEA:26301,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:58639; EC=4.1.1.97;
CC Evidence={ECO:0000256|ARBA:ARBA00001163};
CC -!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from
CC urate: step 3/3. {ECO:0000256|ARBA:ARBA00004754}.
CC -!- SIMILARITY: Belongs to the OHCU decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00005793}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01084860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004774883.1; XM_004774826.3.
DR STRING; 9669.ENSMPUP00000005050; -.
DR Ensembl; ENSMPUT00000005135.1; ENSMPUP00000005050.1; ENSMPUG00000005088.1.
DR GeneID; 101686267; -.
DR KEGG; mpuf:101686267; -.
DR CTD; 646625; -.
DR eggNOG; KOG0848; Eukaryota.
DR GeneTree; ENSGT00390000002395; -.
DR HOGENOM; CLU_092522_1_0_1; -.
DR OMA; RCQNERA; -.
DR OrthoDB; 2903165at2759; -.
DR UniPathway; UPA00394; UER00652.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005777; C:peroxisome; IEA:Ensembl.
DR GO; GO:0051997; F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006154; P:adenosine catabolic process; IEA:Ensembl.
DR GO; GO:0000255; P:allantoin metabolic process; IEA:Ensembl.
DR GO; GO:0043605; P:amide catabolic process; IEA:Ensembl.
DR GO; GO:0006196; P:AMP catabolic process; IEA:Ensembl.
DR GO; GO:0046059; P:dAMP catabolic process; IEA:Ensembl.
DR GO; GO:0006157; P:deoxyadenosine catabolic process; IEA:Ensembl.
DR GO; GO:0006161; P:deoxyguanosine catabolic process; IEA:Ensembl.
DR GO; GO:0006149; P:deoxyinosine catabolic process; IEA:Ensembl.
DR GO; GO:0046055; P:dGMP catabolic process; IEA:Ensembl.
DR GO; GO:0046038; P:GMP catabolic process; IEA:Ensembl.
DR GO; GO:0006147; P:guanine catabolic process; IEA:Ensembl.
DR GO; GO:0009114; P:hypoxanthine catabolic process; IEA:Ensembl.
DR GO; GO:0006204; P:IMP catabolic process; IEA:Ensembl.
DR GO; GO:0006148; P:inosine catabolic process; IEA:Ensembl.
DR GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0009115; P:xanthine catabolic process; IEA:Ensembl.
DR Gene3D; 1.10.3330.10; Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 1.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR017580; OHCU_decarboxylase-1.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR NCBIfam; TIGR03164; UHCUDC; 1.
DR PANTHER; PTHR43466; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR43466:SF1; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1.
DR Pfam; PF09349; OHCU_decarbox; 1.
DR SUPFAM; SSF158694; UraD-Like; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 10..166
FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF09349"
SQ SEQUENCE 174 AA; 19556 MW; 92E7C3F1B81EA918 CRC64;
MQAMDIEKVN SMDFGEFVDV FGNVIERCPL IAAAVWSQRP FSNLEDLEKH FFAFIDALPQ
SGQEGILRCH PDLAGRELQR GTLTAESQRE QRSAGLTSLN AEERLRLAEL NAQYRARFGF
PFVLAARLSD RAAVPRELAR RLHCPPEQEL RTALGEVKKI GHLRLADLLG AEQT
//
