ID M3Y2Y1_MUSPF Unreviewed; 567 AA.
AC M3Y2Y1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Geranylgeranyl transferase type-2 subunit alpha {ECO:0000256|ARBA:ARBA00014772, ECO:0000256|RuleBase:RU367120};
DE EC=2.5.1.60 {ECO:0000256|ARBA:ARBA00012656, ECO:0000256|RuleBase:RU367120};
DE AltName: Full=Geranylgeranyl transferase type II subunit alpha {ECO:0000256|RuleBase:RU367120};
GN Name=RABGGTA {ECO:0000313|Ensembl:ENSMPUP00000005682.1,
GN ECO:0000313|RefSeq:XP_004755274.1, ECO:0000313|RefSeq:XP_004755275.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005682.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000005682.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004755274.1, ECO:0000313|RefSeq:XP_004755275.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004755274.1,
RC ECO:0000313|RefSeq:XP_004755275.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from
CC geranyl-geranyl pyrophosphate to cysteines occuring in specific C-
CC terminal amino acid sequences. {ECO:0000256|RuleBase:RU367120}.
CC -!- FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from
CC geranylgeranyl diphosphate to both cysteines of Rab proteins with the
CC C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A
CC and RAB7A. {ECO:0000256|ARBA:ARBA00002902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] =
CC diphosphate + S-geranylgeranyl-L-cysteinyl-[protein];
CC Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533,
CC ChEBI:CHEBI:86021; EC=2.5.1.60;
CC Evidence={ECO:0000256|ARBA:ARBA00001577,
CC ECO:0000256|RuleBase:RU367120};
CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit alpha
CC family. {ECO:0000256|ARBA:ARBA00006734, ECO:0000256|RuleBase:RU367120}.
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DR EMBL; AEYP01038842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004755274.1; XM_004755217.3.
DR RefSeq; XP_004755275.1; XM_004755218.3.
DR STRING; 9669.ENSMPUP00000005682; -.
DR Ensembl; ENSMPUT00000005781.1; ENSMPUP00000005682.1; ENSMPUG00000005729.1.
DR GeneID; 101680778; -.
DR KEGG; mpuf:101680778; -.
DR CTD; 5875; -.
DR eggNOG; KOG0529; Eukaryota.
DR GeneTree; ENSGT00550000075121; -.
DR HOGENOM; CLU_031996_3_2_1; -.
DR OMA; PKSYNAW; -.
DR OrthoDB; 5489560at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0004663; F:Rab geranylgeranyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0097354; P:prenylation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.120; Protein prenylyltransferase; 1.
DR Gene3D; 2.60.40.1130; Rab geranylgeranyltransferase alpha-subunit, insert domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002088; Prenyl_trans_a.
DR InterPro; IPR036254; RabGGT_asu_insert-dom_sf.
DR InterPro; IPR009087; RabGGT_asu_insert-domain.
DR PANTHER; PTHR11129:SF2; GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11129; PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF01239; PPTA; 4.
DR Pfam; PF07711; RabGGT_insert; 1.
DR SMART; SM00369; LRR_TYP; 2.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR SUPFAM; SSF48439; Protein prenylyltransferase; 1.
DR SUPFAM; SSF49594; Rab geranylgeranyltransferase alpha-subunit, insert domain; 1.
DR PROSITE; PS51147; PFTA; 5.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Prenyltransferase {ECO:0000256|ARBA:ARBA00022602,
KW ECO:0000256|RuleBase:RU367120};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU367120,
KW ECO:0000313|RefSeq:XP_004755274.1}.
FT DOMAIN 245..346
FT /note="Rab geranylgeranyltransferase alpha subunit insert-
FT domain"
FT /evidence="ECO:0000259|Pfam:PF07711"
SQ SEQUENCE 567 AA; 64840 MW; 6E21980E6CC13130 CRC64;
MHGRLKVKTS EEQAKAKRLE REQKLKLYQS ATQTVFQKRQ AGELDESVLE LTSQILGANP
DFATLWNCRR EVLQQLEAQK SPEELAALVK TELGFLESCL RVNPKSYGTW HHRCWLLSRL
PEPNWARELE LCARFLEVDE RNFHCWDYRR FVATQAAVPP AEELAFTDSL ITRNFSNYSS
WHYRSCLLPQ LHPQPDSGSQ GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD
PQDALRCLHV SRDEACLTVS FSRPILVGSG TETLLLMVDE SPLAVEWRTP DGRTRPSHVW
LCDLPAASLN DQLPQHTFRV IWTAGDAQKE CVLLKGRQEG WCRDSATDEQ LFRCELSVEK
STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY EKETLQYFQT LKAVDPMRAA
YLDDLRSKFL VENSVLKMEY AEVRVLHLGH KDLTVLCHLE QLLLVTHLDL SHNRLRALPP
ALAALRCLEV LQANDNTIES LDGVANLPRL RELSLCNNRL QQPTVLQPLV SCPKLVLLHL
QGNPLCQAVG ASEHLAELLP SINSILT
//
